A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1 Antibody in Cynomolgus Monkey

(2016) Chee M. Ng et al.   AAPS Journal

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

(2015) Katherine L. Gill et al.   AAPS Journal

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation

(2015) Christoph Thiel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Development of a physiologically based pharmacokinetic model for a domain antibody in mice using the two-pore theory

(2015) Armin Sepp et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide

(2015) Elliot Offman et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development

(2015) Aman P. Singh et al.   PHARMACEUTICAL RESEARCH

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

(2015) Manoranjenni Chetty et al.   Frontiers in Immunology

Biologics: An Update and Challenge of Their Pharmacokinetics

(2014) Shaojun Shi   CURRENT DRUG METABOLISM

Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models

(2014) Ludivine Fronton et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Characterization and screening of IgG binding to the neonatal Fc receptor

(2014) Tobias Neuber et al.   mAbs

Quantitative cumulative biodistribution of antibodies in mice

(2014) Victor Yip et al.   mAbs

Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody

(2014) Kenta Haraya et al.   XENOBIOTICA

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

(2013) Brian Gurbaxani et al.   MOLECULAR IMMUNOLOGY

Physiology of Blood–Brain Interfaces in Relation to Brain Disposition of Small Compounds and Macromolecules

(2013) N. Strazielle et al.   MOLECULAR PHARMACEUTICS

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

(2012) Yang Chen et al.   AAPS Journal

Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches

(2012) Hannah M. Jones et al.   AAPS Journal

Investigation of the Role of FcγR and FcRn in mAb Distribution to the Brain

(2012) Lubna Abuqayyas et al.   MOLECULAR PHARMACEUTICS

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Therapeutic Mechanism and Efficacy of the Antibody-Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9

(2011) H. M. Petrul et al.   MOLECULAR CANCER THERAPEUTICS

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

(2011) Thomas Eissing   Frontiers in Physiology

Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-  Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys

(2010) R. Deng et al.   DRUG METABOLISM AND DISPOSITION

Investigation of the Influence of FcRn on the Distribution of IgG to the Brain

(2009) Amit Garg et al.   AAPS Journal

Target-mediated drug disposition model: approximations, identifiability of model parameters and applications to the population pharmacokinetic–pharmacodynamic modeling of biologics

(2009) Leonid Gibiansky et al.   Expert Opinion on Drug Metabolism & Toxicology

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

(2009) Y. A. Yeung et al.   JOURNAL OF IMMUNOLOGY

Physiologically based pharmacokinetic model for T84.66: A monoclonal anti-CEA antibody

(2009) Shweta R. Urva et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn

(2009) Kristi Baker et al.   Seminars in Immunopathology

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Open-label, dose escalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A

(2008) Claribel P. Taylor et al.   VACCINE

Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics

(2007) B.J. Anderson et al.   Annual Review of Pharmacology and Toxicology

A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs

(2007) Jasmine P. Davda et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO