Article
Biochemistry & Molecular Biology
Blake R. Rushing
Summary: Drug resistance is a significant problem in cancer therapy, and there is still much to be learned about its molecular underpinnings. This study used a multi-omics approach to investigate the molecular networks and metabolic processes that differentiate cancer cells sensitive or resistant to antifolates, a commonly used class of anticancer drugs. The results provide new insights into the mechanisms of intrinsic antifolate resistance and may inform the development of novel therapeutic strategies and personalized treatment approaches.
Article
Oncology
Julia Krushkal, Simarjeet Negi, Laura M. Yee, Jason R. Evans, Tanja Grkovic, Alida Palmisano, Jianwen Fang, Hari Sankaran, Lisa M. McShane, Yingdong Zhao, Barry R. O'Keefe
Summary: Investigation revealed associations between gene expression and the response of cancer cells to specific categories of natural products, suggesting potential mechanisms of action and paving the way for future targeted cancer chemotherapy agent discovery and design.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Hari Sankaran, Simarjeet Negi, Lisa M. McShane, Yingdong Zhao, Julia Krushkal
Summary: This study analyzed the activity of Indian natural products in the NCI-60 cell line panel and identified associations with gene expression and mutations related to cancer treatment. The findings are important for understanding the mechanisms of these Indian natural products.
Review
Pharmacology & Pharmacy
Ling Zhou, Huiguo Liu, Kui Liu, Shuang Wei
Summary: Gold compounds have shown promising results in cancer therapy by interacting with the immune system, inducing innate immune responses and promoting adaptive immune responses to support anti-tumor immune responses. Gold nanoparticles have the potential to improve the effectiveness of immunotherapy and reduce the toxicity and side effects of treatment processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Blake R. Rushing
Summary: This study used a multi-omics approach to explore the molecular determinants affecting the response of cancer cells to alkylating agents. Through integrated pathway analysis, key metabolic pathways were identified, and potential druggable targets were revealed. Copy number variant analysis also identified notable differences in genes associated with metabolic changes, protein trafficking, and miRNAs between drug-sensitive and drug-resistant cells. These findings provide a comprehensive view of the molecular landscape underlying the response to alkylating agents and can contribute to the development of personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Hawraa S. Al-Buthabhak, Valerio Falasca, Yu Yu, Alexandre N. Sobolev, Brian W. Skelton, Stephen A. Moggach, Vito Ferro, Hani Al-Salami, Murray Baker
Summary: Novel complexes of (NHC)Au(SCOR) were synthesised and characterised using spectroscopic techniques and X-ray diffraction. The results indicated that thiocarboxylate ligands have comparable electron donor ability with NHCs. The complexes were stable at room temperature in solid state but showed disproportionation reactions in solution. The thiocarboxylate ligand in (NHC)Au(SCOR) underwent rapid exchange with other thiocarboxylate or thiolate ligands. Furthermore, these complexes exhibited toxicity against cisplatin-resistant ovarian cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Oncology
Simon Heumos, Sandra Dehn, Konstantin Braeutigam, Marius C. Codrea, Christian M. Schuerch, Ulrich M. Lauer, Sven Nahnsen, Michael Schindler
Summary: This study identified specific cell surface receptor biomarkers for colon and renal cancer through analyzing the surface receptors of tumor cells, with CD106 (VCAM1) identified as a promising novel immunotherapeutic target for renal cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Jonas F. Schlagintweit, Christian H. G. Jakob, Nicola L. Wilke, Marie Ahrweiler, Corazon Frias, Jerico Frias, Marcel Koenig, Eva-Maria H. J. Esslinger, Fernanda Marques, Joao F. Machado, Robert M. Reich, Tania S. Morais, Joao D. G. Correia, Aram Prokop, Fritz E. Kuehn
Summary: The Mes- and iPr-substituted gold(I) bis(1,2,3-triazol-5-ylidene) complexes exhibit potent antiproliferative activity in various cancer cell lines, inducing apoptosis in common malignant blood cells while sparing non-malignant cells. Additionally, they overcome resistances against established cytostatic drugs and show synergistic effects when combined with daunorubicin. These results highlight the promising potential of these complexes as easily modifiable anticancer metallodrugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Thomas Scattolin, Petra Lippmann, Marek Belis, Kristof van Hecke, Ingo Ott, Steven P. Nolan
Summary: A straightforward synthetic route to new N-heterocyclic carbene (NHC)-gold-steroidyl complexes is reported, which displayed good cytotoxicity against cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Federica Guarra, Alessandro Pratesi, Chiara Gabbiani, Tarita Biver
Summary: Metal complexes of N-heterocyclic carbene (NHC) ligands are attracting increasing attention for therapeutic purposes. Among different metal centres like Au, Ag, and Cu, they exhibit anti-inflammatory, antimicrobial, and anti-tumour properties. This review focuses on the biological targets of these compounds and provides insights into their mechanistic behavior based on structure-activity relationships.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Polymer Science
Masahiro Kaneko, Masahito Ishikawa, Shuji Nakanishi, Kazuhiko Ishihara
Summary: Redox phospholipid polymers composed of ferrocene or quinone units were prepared as anticancer redox polymers, which can disrupt intracellular redox state and selectively suppress the viability of cancer cells based on their reactivity with intracellular redox species and O-2. The redox potential of the polymers plays a critical role in determining the impact on the viability of human cancer and normal cells.
Article
Chemistry, Analytical
Lin Zhang, Yu Wang, Yuqiao Wang, Meiling Guo, Zhouyuan Li, Xianbo Jin, Hongzhi Du
Summary: Reliable H2O2 sensors for in situ cellular monitoring under drug stimulation can be developed by using graphene and shape-controlled gold nanostructures. The as-synthesized nanostructured H2O2 sensors showed high sensitivity (5.07×10-4 mA μmol L-1 cm-2) and good detection capability (the lowest detection limit is 4.5 μmol L-1 (S/N = 3)). The electrochemical biosensor demonstrated remarkable sensitivity, accuracy, and rapidity compared with traditional enzymatic detection kits. This technology can be applied to assess the antitumor properties of candidate drugs and inspire developments for personalized health care monitoring and cancer treatment.
Article
Chemistry, Medicinal
Jingxing Wu, Yi Xiao, Mujie Lin, Hanxuan Cai, Duancheng Zhao, Yirui Li, Hailin Luo, Chuanqi Tang, Ling Wang
Summary: In this study, a total of 832 classification models were constructed using the FP-GNN deep learning method, based on the collection of 485,900 compounds and their bioactivity records. These models showed considerable predictive performance, with the highest AUC values of 0.91, 0.88, and 0.91 for targets, academia-sourced cell lines, and NCI60 cancer cell lines, respectively. A user-friendly webserver called DeepCancerMap was developed based on these models, providing various functions for anticancer drug discovery.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Andy Guzman Rodriguez, Marquiza Sablon Carrazana, Chrislayne Rodriguez Tanty, Martijn J. A. Malessy, Gaston Fuentes, Luis J. Cruz
Summary: Cancer has been a lethal disease with high incidence and invasive treatments. Nanotechnology provides a promising alternative for cancer treatment by using nanocarriers to transport anticancer drugs. This study aims to explore different nanocarriers and new routes to reduce the incidence of cancer to very low levels in humans.
Article
Chemistry, Physical
Sughra Gulzar, Umme Ammara, Zeeshan Abid, Munazza Shahid, Raja Shahid Ashraf, Nadeem Baig, Abdel-Nasser Kawde, Gaurav A. Bhatia, Anvarhusein A. Isab, Muhammad Altaf
Summary: In this study, five new gold(I)-NHC complexes with thione ligands were synthesized and their structures were elucidated. Three of the complexes were subjected to single-crystal X-ray diffraction studies, revealing a close to linear coordination geometry of gold(I) atoms. In vitro experiments demonstrated that these synthesized complexes exhibited inhibitory effects against colon, lung, and breast cancer cells. Electrochemical reactions were performed to investigate the possible mechanism of interaction between the complexes and biomolecules.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
C. R. Shahini, Gautam Achar, Srinivasa Budagumpi, Helge Muller-Bunz, Matthias Tacke, Siddappa A. Patil
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2018)
Article
Chemistry, Organic
Oyinlola Dada, Goar Sanchez-Sanz, Matthias Tacke, Xiangming Zhu
TETRAHEDRON LETTERS
(2018)
Article
Biochemistry & Molecular Biology
Danielle Curran, Oyinlola Dada, Helge Mueller-Bunz, Matthias Rothemund, Goar Sanchez-Sanz, Rainer Schobert, Xiangming Zhu, Matthias Tacke
Article
Chemistry, Organic
Cian Mc Carthy, Matthias Tacke, Xiangming Zhu
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Cillian O'Beirne, Nada F. Alhamad, Qinxi Ma, Helge Mueller-Bunz, Kevin Kavanagh, Geraldine Butler, Xiangming Zhu, Matthias Tacke
INORGANICA CHIMICA ACTA
(2019)
Article
Chemistry, Physical
Lei Ma, Shiyan Yuan, Hanfei Zhu, Taotao Jiang, Xiangming Zhu, Chunshan Lu, Xiaonian Li
Article
Oncology
Wolfgang Walther, Dhiyaa Althagafi, Danielle Curran, Cillian O'Beirne, Cian Mc Carthy, Ingo Ott, Uttara Basu, Britta Buttner, Anja Sterner-Kock, Helge Mueller-Bunz, Goar Sanchez-Sanz, Xiangming Zhu, Matthias Tacke
Article
Biochemistry & Molecular Biology
Danielle Curran, Helge Mueller-Bunz, Sofia Baer, Rainer Schobert, Xiangming Zhu, Matthias Tacke
Article
Chemistry, Organic
Zoe Beato, Xiangming Zhu
Summary: A new method for synthesizing superarmed thioglycosides via the ring opening of 1,2-orthoesters is reported, ensuring the necessary stereochemistry and using trimethylsilyl thioethers as sulfur nucleophiles to avoid the use of unpleasant free thiols.
Article
Biochemistry & Molecular Biology
Cillian O'Beirne, Magdalena E. Piatek, Jen Fossen, Helge Muller-Bunz, David R. Andes, Kevin Kavanagh, Siddappa A. Patil, Marcus Baumann, Matthias Tacke
Summary: N-heterocyclic silver carbene compounds have shown excellent inhibition against pathogenic bacteria and fungi, with the addition of virulence targeting substituents and continuous flow synthesis leading to the development of new complexes with promising potential for antimicrobial activity.
Article
Chemistry, Organic
Cian Mc Carthy, Xiangming Zhu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Ashanty M. Melo, Lei Zhang, Eilis F. Dockry, Andreea Petrasca, Yasmeen G. Ghnewa, Eamon P. Breen, Maria E. Morrissey, Ciara O'Reilly, Robyn Bruen, Andrew O'Meara, Joanne Lysaght, Xiangming Zhu, Derek G. Doherty
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Van Ha Nguyen, John H. K. Yip
Summary: In this study, eight PtII-azulene complexes were synthesized to investigate the effect of metalation on the electronic structures, spectroscopy, and luminescence of organic chromophores. The results showed that the attachment of Pt substituents to azulene affected the HOMOs, LUMOs, and luminescence properties. The study provides insights into the role of metalation in modifying the properties of organic chromophores.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Virender Singh, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: This study synthesized two types of neutral binuclear metallocycles using a one-pot solvothermal method and characterized their structures. The analysis revealed that these complexes adopt a binuclear heteroleptic cyclic architecture and belong to phosphine oxide donor (P=O)-based supramolecular coordination cyclic complexes.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Radhey S. Srivastava
Summary: This study demonstrates the effectiveness of zero-valent elements as reductants for the deoxydehydration reaction of polyols catalyzed by ONO-pincer ligated molybdenum dioxo. The insolubility and easy separability of the reductants and their oxidized products during the reaction are emphasized. Additionally, the choice of ligand has an impact on the catalytic performance of the reaction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Hao Zhou, Yajun Sun, Li Deng, Weiran Yang, Yuehui Li
Summary: Efficient Ru-catalyzed hydrogenation of aldehydes was achieved using carbazole-derived phosphine ligands, with the crucial role of N-H moiety in promoting the catalytic reaction. The method was successfully applied in the Co/Ru-catalyzed hydroformylation process, resulting in the production of long-chain alcohols with excellent yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Theodor Danescu, Alexandru Lupan, Radu Silaghi-Dumitrescu, R. Bruce King
Summary: The structures and energies of complexes containing (Me2C2N2P)2Ru2(CO)n and (Me2C2N2P)2Fe2(CO)n have been studied. Low-energy structures are characterized by the presence of bridging diazaphospholyl rings, while higher-energy structures involve different ligand structures.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Savannah C. Kapper, Aamani Ponnekanti, Jonas Schaab, Tian-yi Li, Christine L. Chung, Gael Ung, Peter I. Djurovich, Mark E. Thompson
Summary: Organometallic iridium complexes with two cyclometalated ligands and one bis-oxazoline derived ancillary ligand were studied. These complexes have emission spanning across the visible and near-ultraviolet region, with moderate to high photoluminescence quantum yields. The (ppy)2Ir(BOX-CN) complexes were resolved into Delta- and Lambda-diastereomers based on solubility differences.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Zahra Karimi Sangari, Hossein Naeimi
Summary: In this research, a nanostructured CoCuFe2O4 catalyst was prepared using a brief and useful synthetic strategy. This catalyst was used for synthesizing 1,2,4,5-tetrasubstituted imidazole derivatives under ultrasonic irradiation. The approach offers advantages such as high efficiency, short reaction times, simplicity of the reaction medium, accelerated reaction rates, and easier separation and purification of products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Rukhsana Gul, Wajid Munir, Ebraheem Abdu Musad Saleh, Shaukat Shujah, Muhammad Sirajuddin, Saira Tabassum, Khalil Ur Rehman, Dilfaraz Khan, Sameerah I. Al-Saeedi, Ehab A. Abdelrahman
Summary: Two new Schiff base ligands were synthesized and used to form copper, nickel, and cobalt complexes. The synthesized compounds were characterized and screened for various biological activities. The metal complexes showed better activities in antibacterial, antifungal, antidiabetic, and antioxidant assays.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Review
Chemistry, Inorganic & Nuclear
Ahsan Nazir, Pengwei Huo, Ameena Tur Rasool
Summary: This review explores the potential of g-C3N4-based S-scheme heterojunctions in addressing environmental issues. It summarizes the mechanism and preparation techniques of S-scheme heterojunctions based on g-C3N4, and presents recent studies on their applications in pollutant removal, CO2 reduction, hydrogen production, and bacterial disinfection. The review concludes with an outlook on future challenges for g-C3N4-based S-scheme heterojunctions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Francois Mazars, Koffi Senam Etse, Guillermo Zaragoza, Lionel Delaude
Summary: The activity of three Pd-PEPPSI catalyst precursors with N-heterocyclic carbene (NHC) ligands derived from caffeine and theophylline in Mizoroki-Heck reactions was tested. The results showed that the catalysts achieved high conversions and yields, especially in the presence of electron-withdrawing substituents.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Bo-Han Wu, Xue Zhou, Lin Liu, Zheng-Bo Han
Summary: Researching carbon dioxide removal from flue gas and natural gas is crucial. Metal-organic frameworks (MOFs) are commonly used in adsorption due to their high surface area, porosity, and chemical properties. An ultra-microporous MOF CPM-20(Co) with mixed ligand was synthesized using inexpensive ligands. The material exhibited high selectivities and low regenerative energy, making it a promising option for CO2 separation in industries.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)