Review
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Pierre Picchetti, Angela Casini
Summary: The discovery of medicinal properties of gold complexes has led to the development of new anticancer drugs, which are unique in their modes of action. Current research focuses on designing drug leads with enhanced pharmacological activities and improving physicochemical properties of gold compounds. Encapsulation of gold compounds in nanocarriers or their grafting onto targeted delivery vectors may lead to new nanomedicines for clinical applications. This article provides an overview of gold anticancer compounds and a detailed review of nanoparticle-based delivery systems for gold chemotherapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Bilal Javed, Xinyi Zhao, Daxiang Cui, James Curtin, Furong Tian
Summary: The study synthesized Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel loaded with curcumin and piperine to treat GBM, which exhibited enhanced anticancer properties, improved drug toxicity and release, and induced apoptosis through endocytic pathways. The experimental evidence suggests that the combinatorial curcumin-piperine gold nanogels have the potential to overcome the limitations of conventional chemotherapeutic treatments for glioma cells.
Review
Oncology
Zile Fu, Xiaoming Zhang, Yanfeng Gao, Jia Fan, Qiang Gao
Summary: This article discusses the crucial role of the immune system in cancer initiation, evolution, invasion, and metastasis. Therapeutics targeting the modulation or boosting of anticancer immune responses have advanced significantly, with the identification of both conventional and emerging drugs that can enhance anticancer immunity. Additionally, advancements in drug delivery systems allow for novel therapeutic strategies and new modes of action in tumor immunology.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Xianya Qin, Conglian Yang, Hongbo Xu, Runzan Zhang, Dan Zhang, Jingyao Tu, Yuanyuan Guo, Boning Niu, Li Kong, Zhiping Zhang
Summary: The biosynthesis of nanomedicine using tumor cells as a basis has shown potential for enhancing radiotherapy sensitivity and promoting immune responses. Au@MC38's intracellular biomineralization and exocytosis process can be regulated by cellular metabolites and other factors, potentially leading to effective immune responses through radio-sensitization. Additionally, the strategy has demonstrated an effective inhibition of primary and metastatic tumors, as well as improving survival benefits when combined with immune checkpoint blockade.
Article
Chemistry, Multidisciplinary
Najlaa S. Al-Radadi
Summary: The synthesis of environmentally friendly gold nanoparticles using green methods has shown promising antioxidant and antibacterial properties, exhibiting potential therapeutic effects on breast and liver cancer cells.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Oncology
Lucillia Bezu, Alejandra Wu Chuang, Allan Sauvat, Juliette Humeau, Wei Xie, Giulia Cerrato, Peng Liu, Liwei Zhao, Shuai Zhang, Julie Le Naour, Jonathan Pol, Peter van Endert, Oliver Kepp, Fabrice Barlesi, Guido Kroemer
Summary: This study investigates the anticancer effects of six local anesthetics used in clinical practice. The results suggest that local anesthetics induce immunogenic stress responses in cancer cells, leading to antitumor effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Andy Guzman Rodriguez, Marquiza Sablon Carrazana, Chrislayne Rodriguez Tanty, Martijn J. A. Malessy, Gaston Fuentes, Luis J. Cruz
Summary: Cancer has been a lethal disease with high incidence and invasive treatments. Nanotechnology provides a promising alternative for cancer treatment by using nanocarriers to transport anticancer drugs. This study aims to explore different nanocarriers and new routes to reduce the incidence of cancer to very low levels in humans.
Article
Chemistry, Physical
Marianna Pannico, Pellegrino Musto
Summary: A SERS colloidal solution of gold nanoparticles was used as a sensing platform for Therapeutic Drug Monitoring. By adjusting the pH towards acidic values, sensitivity of the platform was improved. A normalizing procedure based on enhanced elastic scattering signal was used to address the time-dependent SERS response, leading to an accurate and reproducible quantitative analysis within a range of 1 - 15 μM.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Rossana Galassi, Lorenzo Luciani, Valentina Gambini, Silvia Vincenzetti, Giulio Lupidi, Augusto Amici, Cristina Marchini, Junbiao Wang, Stefania Pucciarelli
Summary: Phosphane gold(I) compounds were evaluated for screening on breast cancer cell panels, with compounds showing specific environments and components displaying activity. These compounds exhibited strong cytotoxicity, varying enzymatic activities, and binding properties in different cell lines.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Nouran Rezk, Abdallah S. Abdelsattar, Salsabil Makky, Assmaa H. Hussein, Azza G. Kamel, Ayman El-Shibiny
Summary: This study biosynthesized Au-Ag nanoparticles using propolis and examined their antibacterial activity against antibiotic-resistant bacteria as well as their anticancer activity. The results showed that these nanoparticles exhibited antibacterial activity against various bacteria and had a cytotoxic effect on HEPG2 cells.
Article
Pharmacology & Pharmacy
Nesma El-Sayed, Evgeniia Korotchenko, Sandra Scheiblhofer, Richard Weiss, Marc Schneider
Summary: Multifunctional gelatin nanoparticles modified by NIR-emitting gold/silver alloy nanoclusters and loaded with ovalbumin as a model antigen have been developed. These nanoparticles showed promising vaccine potential in dendritic cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Qi Shang, Yabing Dong, Yun Su, Faith Leslie, Mingjiao Sun, Feihu Wang
Summary: Cancer immunotherapy is a promising therapeutic strategy that reprograms the immune system to eliminate cancer cells. Local scaffold-based delivery systems have shown potential in overcoming the limitations of systemic administration, improving site-specific efficacy, and minimizing systemic toxicity. Future perspectives and challenges for clinical translation and applications of local scaffold-assisted cancer immunotherapy are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Spectroscopy
Sonia Khurana, Shrikant Kukreti, Mahima Kaushik
Summary: The distance-dependent optical properties of colloidal gold nanoparticles can be used for designing colorimetric sensing modalities for the detection of various analytes. A simple and facile colorimetric detection assay for Sanguinarine (SNG) and Calf Thymus DNA (Ct-DNA) has been developed using citrate-reduced gold nanoparticles (CI-Au NPs). The optimized sensing system allows for the detection and quantification of SNG & Ct-DNA in real samples with satisfactory results and finds application in drug or DNA monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Multidisciplinary
Jinpeng Han, Tao Sheng, Yuqi Zhang, Hao Cheng, Jianqing Gao, Jicheng Yu, Zhen Gu
Summary: The human immune system plays a crucial role in various diseases. Manipulating the immune response network with bioresponsive immunotherapeutic materials can maximize therapeutic efficacy and minimize side effects. Integration of smart bioresponsive materials with immunoactive agents allows targeted release of agents to reduce toxicity and manipulate immune cells for desired responses. This review emphasizes the design principles of bioresponsive immunotherapeutic materials and discusses their critical roles in immune response manipulation.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhicheng Jiang, Jinjie Duan, Xingjie Guo, Ya Ma, Chunjiong Wang, Bi Shi
Summary: In this study, gold (Au) nanoparticles supported on lignin-tannin (LT) micro-/nanoparticles were prepared via a green and novel method without the use of an additional reducing agent. Increasing the proportion of tannins led to higher amounts of Au species on LT particles, but also decreased the thermal stability of the particles.