Review
Biochemistry & Molecular Biology
Anna Ciesielska, Marta Matyjek, Katarzyna Kwiatkowska
Summary: This article discusses the role of TLR4 in promoting inflammatory responses, including internalization and intracellular trafficking of exogenous endotoxin and bacteria. The authors emphasize the significant impact of internalization rate and endo-lysosomal compartment transport rate on inflammatory responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Food Science & Technology
Tomasz Piechowiak, Maciej Balawejder
Summary: The study demonstrates that adding a flavonoid-phosphatidylcholine coating during storage of flaxseed oil effectively inhibits lipid peroxidation and reduces malondialdehyde levels. Additionally, antioxidants released from onion skin extract help decrease the degree of fatty acid modification and enhance the biological activity of flaxseed oil.
FOOD PACKAGING AND SHELF LIFE
(2021)
Article
Engineering, Biomedical
Lun Jing, Solene Rota, Florian Olivier, David Momier, Jean-Marie Guigonis, Sebastien Schaub, Michel Samson, Jean-Michel Bouler, Jean-Claude Scimeca, Nathalie Rochet, Patricia Lagadec
Summary: Blood proteins adhering to bone substitute surface play a crucial role in affecting both biomaterial bioactivity and bone healing. The presence of 80-200 μm biphasic calcium phosphate particles in a blood clot is associated with higher expression of fibrinogen, which activates blood cells through the Myd88- and NF-κB-dependent TLR4 signaling pathway.
ACTA BIOMATERIALIA
(2021)
Article
Immunology
Shuhe Ma, Kosaku Murakami, Rintaro Saito, Hiromu Ito, Koichi Murata, Kohei Nishitani, Motomu Hashimoto, Masao Tanaka, Masahi Taniguchi, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Koichiro Ohmura, Akio Morinobu, Tsuneyo Mimori
Summary: This study identified differences in the quantity and quality of CD14-positive cells in the infrapatellar fat pads and subcutaneous fat tissues of OA and RA patients. Patients treated with bDMARDs showed a higher ratio of CD14(++)CD80(+) cells/CD14(++)CD163(+) cells in the IFP, indicating localized inflammation. This suggests that adipose tissue-derived innate immune cells could be a potential target for new therapeutic strategies in inflammatory joint diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hsing-Chun Kuo, Shiou-Lan Chen, Shu-Chen Chiu, Kam-Fai Lee, Chun-Hsien Chu
Summary: The development of microglial endotoxin tolerance (ET) plays a critical role in protecting neurons, and this study aimed to investigate the mechanisms involved. The results showed that LPS-induced TNF-a tolerance in microglia depended on LBP. Additionally, early pro-inflammatory cytokines induced by LPS did not contribute to microglial ET. Moreover, inhibition of p38 MAPK disrupted the microglial TNF-a reduction and neuroprotection.
Article
Biochemistry & Molecular Biology
Bo-Young Kim, Yonghae Son, Byoung Joon Kim, Sung Woon Chung, Dongjun Lee, Seong-Kug Eo, Koanhoi Kim
Summary: The abundance of 7-oxysterols in atherosclerotic lesions leads to elevated expression of CD14 in monocytic cells. In this study, we investigated the effects of three atheroma-relevant 7-oxysterols on CD14 levels in THP-1 cells. The results showed that 7-α-hydroxycholesterol had the strongest induction of CD14 expression and enhanced monocytic cell responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Haranatha R. Potteti, Lalith K. Venkareddy, Patrick M. Noone, Aparna Ankireddy, Chandramohan R. Tamatam, Dolly Mehta, Chinnaswamy Tiruppathi, Sekhar P. Reddy
Summary: This study demonstrates the crucial role of Nrf2 in optimal A20 transcriptional induction in macrophages in response to endotoxin, and shows that this regulation occurs in a contextual manner.
Review
Immunology
Daniel Sharygin, Leonidas G. Koniaris, Clark Wells, Teresa A. Zimmers, Tewfik Hamidi
Summary: The cell surface antigen CD14 acts as a co-receptor for toll-like receptors (TLRs) in macrophages and monocytes, but also has roles in disease responses in epithelial and endothelial cells. CD14 expression is altered in various non-immune cell types in response to disease states, and soluble CD14 can initiate signaling in these cells. This review examines CD14's role in innate immunity and its potential functions in non-immune cells and associated human diseases.
Article
Cell Biology
John Audley, Emily F. Gliniewicz, Kol A. Zarember, Hanna S. Hong, Gal Wald, Douglas B. Kuhns, Elizabeth Kang, Harry L. Malech, Anthony F. Suffredini, Robert J. Noveck, Mark J. Dinubile, Susan L. Levinson, Thomas P. Stossel, John Gallin
Summary: In this study, lower concentrations of plasma gelsolin (pGSN) were found in clinically stable patients with chronic granulomatous disease (CGD) compared to healthy volunteers, while X-linked carriers of CGD had normal pGSN levels. However, pGSN levels significantly increased in CGD patients following bone marrow transplantation. Healthy volunteers challenged with intravenous endotoxin did not show significant changes in pGSN, indicating that pGSN is not an acute phase reactant.
Article
Agriculture, Multidisciplinary
Conghui Liu, Xin Wang
Summary: The stability and uniformity of emulsions are influenced by different emulsification methods with varying ratios of SPI/SLT. Emulsions stabilized by SPI-SLT treated with ultrasound showed better stability and uniformity. The combination of high-speed homogenization and ultrasound improved the performance of SPI-stabilized Pickering emulsion, while SLT-stabilized emulsions had poorer uniformity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Review
Chemistry, Multidisciplinary
Vivian Hirsch, Alice Blufstein, Christian Behm, Oleh Andrukhov
Summary: This review investigates the levels of mCD14 and sCD14 in various tissues of periodontitis patients, finding that mCD14 levels are decreased in peripheral blood monocytes, while sCD14 levels tend to be increased in sera, gingival crevicular fluid, and biopsies of periodontitis patients. The interpretation of data obtained from qPCR, ELISA, and flow cytometry regarding CD14 in gingival biopsies and periodontal tissues is found to be questionable.
APPLIED SCIENCES-BASEL
(2021)
Article
Critical Care Medicine
Anna Bergstrom, Miklos Lipcsey, Anders Larsson, Bei Yang, David Engblom, Michelle S. Chew, Louise Elander
Summary: Acetaminophen attenuates the effects of endotoxin on pulmonary circulation in anesthetized pigs, delaying and reducing the rapid increase in pulmonary artery pressure and pulmonary vascular resistance induced by endotoxin infusion. It also reduces tachycardia and decreases stroke volume without affecting inflammatory parameters, potentially playing a role in severe systemic inflammation.
Article
Immunology
Ludmila Lupu, Klemens Horst, Johannes Greven, Uemit Mert, Judith A. K. Ludviksen, Kristin Pettersen, Corinna Lau, Yang Li, Annette Palmer, Kang Qin, Xing Zhang, Benjamin Mayer, Martijn van Griensven, Markus Huber-Lang, Frank Hildebrand, Tom Eirik Mollnes
Summary: In this study, the combined inhibition therapy of complement factor C5 and TLR co-receptor CD14 was used to reduce thrombo-inflammation and organ damage in a polytrauma pig model. The therapy significantly decreased the levels of terminal complement complex (TCC), CRP, and IL-6 in the blood. It also prevented platelet consumption and TAT formation, and reduced the requirements for norepinephrine. Moreover, the therapy limited organ damage and reduced the levels of blood lipase, LDH, AST, and NGAL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physics, Multidisciplinary
Benjamin Foster, Nicolas Verschueren, Edgar Knobloch, Leonardo Gordillo
Summary: An exactly solvable family of models describing the wrinkling of substrate-supported inextensible elastic rings under compression is identified. The resulting wrinkle profiles are shown to be related to the buckled states of an unsupported ring and are therefore universal. Closed analytical expressions for the resulting universal shapes are provided, including the one-to-one relations between the pressure and tension at which these emerge. The analytical predictions agree with numerical continuation results to within numerical accuracy, for a large range of parameter values, up to the point of self-contact.
PHYSICAL REVIEW LETTERS
(2022)
Article
Agriculture, Dairy & Animal Science
Zuo Wang, Lingmei Zhang, Zhicai Li, Yuannian Yu, Lingyuan Yang, Peihua Zhang, Weijun Shen, Fachun Wan, Jianhua He, Wenjun Xiao, Dasheng Yang, Zhiliang Tan, Shaoxun Tang
Summary: The study revealed that L-theanine could mitigate the detrimental effects of heat stress on dairy cows by reducing LPS translocation and accumulation, as well as alleviating inflammatory reactions in dairy cows during heat stress. Further research is needed to explore the underlying mechanisms of L-theanine in altering LPS and alleviating inflammation.
Article
Transplantation
Solene M. Laville, Aymeric Couturier, Oriane Lambert, Marie Metzger, Nicolas Mansencal, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Bruce M. Robinson, Benedicte Stengel, Sophie Liabeuf, Ziad A. Massy
Summary: This study aimed to determine the association between serum urea levels and adverse cardiovascular events and death in patients with chronic kidney disease (CKD) before renal replacement therapy (RRT). The study found that elevated serum urea levels were associated with increased risk of atheromatous and non-atheromatous cardiovascular events, as well as higher mortality rates.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Fabio R. Salerno, Alireza Akbari, Sandrine Lemoine, Timothy J. Scholl, Christopher W. McIntyre, Guido Filler
Summary: Pediatric CKD is associated with altered tissue sodium concentration compared to healthy controls, with increased sodium concentration in glomerular disease and reduced sodium concentration in tubular disorders.
PEDIATRIC NEPHROLOGY
(2023)
Article
Hematology
Florian Mourre, Roch Giorgi, Antonio Gallo, Franck Boccara, Eric Bruckert, Alain Carrie, Regis Hankard, Jocelyn Inamo, Sandrine Laboureau, Philippe Moulin, Rene Valero, Sophie Beliard
Summary: Background: Animal studies have shown that fetal exposure to high maternal cholesterol levels during pregnancy increases the risk of aortic atheroma in the offspring. However, little is known about the consequences of this exposure on the development of atherosclerotic cardiovascular disease in humans. This study aimed to investigate whether maternal/paternal inheritance of familial hypercholesterolemia (FH) gene mutation could be associated with subclinical coronary atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Charles Fauvel, Guillaume Bonnet, Wilfried Mullens, Clara Ines Saldarriaga Giraldo, Anja Zupan Meznar, Anders Barasa, Mariya Tokmakova, Anastasia Shchendrygina, Francisco Moscoso Costa, Massimo Mapelli, Filip Zemrak, Laurens F. Tops, Nina Jakus, Arian Sultan, Fadel Bahouth, Chahr-Eddine Hadjseyd, Muriel Salvat, Matteo Anselmino, Daniel Messroghli, Vanessa Weberndorfer, Ilya Giverts, Thomas Bochaton, Emmanuelle Berthelot, Damien Legallois, Florence Beauvais, Fabrice Bauer, Nicolas Lamblin, Thibaud Damy, Nicolas Girerd, Laurent Sebbag, Theo Pezel, Alain Cohen-Solal, Giuseppe Rosano, Francois Roubille, Nathan Mewton
Summary: This study aimed to understand the perception of practicing cardiologists and heart failure (HF) specialists regarding the recommendation of initiating four major therapeutic classes simultaneously in patients with heart failure and reduced ejection fraction. The survey findings showed that most cardiologists still preferred the historical approach of sequential initiation, although accelerated introduction and titration were also considered important treatment goals.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Transplantation
Maelys Granal, Denis Fouque, Micher Ducher, Jean-Pierre Fauvel
Summary: This study used artificial intelligence to define the relationship between kalemia, dietary potassium intake, and renal function in chronic kidney disease (CKD) patients. The results showed that strict dietary potassium control is not necessary to regulate kalemia in CKD1-4 patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Anfisa Puchkova-Sistac, Blandine de Lauzon-Guillain, Nicolas Girerd, Jean-Marc Boivin, Erwan Bozec, Ludovic Merckle, Julie-Anne Nazare, Martine Laville, Patrick Rossignol, Sandra Wagner
Summary: This study aimed to assess the associations between eating behavior and cardiovascular damage or metabolic syndrome after 13 years. The results showed that emotional eating was associated with an increased risk of diastolic dysfunction after 13 years. External eating was slightly associated with lower pulse-wave velocity. These findings suggest that cardiovascular prevention should take into account eating behavior and include teaching emotion regulation skills.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Marlene Heinze, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Josep Puig, Robin Lemmens, Vincent Thijs, Keith W. Muir, Norbert Nighoghossian, Alina Koenigsberg, Marit Jensen, Ewgenia Barow, Iris Lettow, Salvador Pedraza, Claus Z. Z. Simonsen, Christian Gerloff, Gotz Thomalla
Summary: This study evaluated the impact of clinical and imaging baseline factors and treatment on early neurological improvement (ENI) in MRI-guided intravenous thrombolysis for unknown onset stroke. The results showed that early neurological improvement is an important indicator of treatment effect, and early administration of thrombolysis increases the likelihood of ENI.
CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Waldmann, Francis Bessiere, Kevin Gardey, Mohamed Bakloul, Emre Belli, Damien Bonnet, Anne-Solene Chaussade, Sarah Cohen, Hubert Delasnerie, Nabil Dib, Sylvie Di Filippo, Arnaud Dulac, Sebastien Hascoet, Roland Henaine, Laurence Iserin, Clement Karsenty, Magalie Ladouceur, Antoine Legendre, Sophie Malekzadeh-Milani, Mansour Mostefa Kara, Jelena Radojevic, Miarisoa Ratsimandresy, Eloi Marijon, Alice Maltret, Paul Khairy, Nicolas Combes
Summary: This study aims to assess the role of EPS in predicting ventricular arrhythmias in patients with tetralogy of Fallot before pulmonary valve replacement. The results show that EPS can effectively predict the presence of ventricular tachycardia and guide treatment decisions.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julien Dreyfus, Yohann Bohbot, Augustin Coisne, Yoan Lavie-Badie, Michele Flagiello, Baptiste Bazire, Florian Eggenspieler, Florence Viau, Elisabeth Riant, Yannick Mbaki, Damien Eyharts, Thomas Senage, Thomas Modine, Martin Nicol, Fabien Doguet, Thierry Le Tourneau, Christophe Tribouilloy, Erwan Donal, Jacques Tomasi, Gilbert Habib, Christine Selton-Suty, Costin Radu, Pascal Lim, Richard Raffoul, Bernard Iung, Jean-Francois Obadia, Etienne Audureau, David Messika-Zeitoun
Summary: This study aimed to evaluate the predictive value of TRI- SCORE for in-hospital mortality in redo ITVS patients and compare its accuracy with conventional surgical risk scores. The study found that TRI- SCORE was the only surgical risk score associated with in-hospital mortality, with an AUC value of 0.83, much higher than logistic EuroSCORE and EuroSCORE II. Therefore, TRI- SCORE can guide the clinical decision-making process.
Article
Critical Care Medicine
Romain Sonneville, Etienne de Montmollin, Damien Contou, Ricard Ferrer, Mohan Gurjar, Kada Klouche, Benjamine Sarton, Sophie Demeret, Pierre Bailly, Daniel da Silva, Etienne Escudier, Loic Le Guennec, Russel Chabanne, Laurent Argaud, Omar Ben Hadj Salem, Martial Thyrault, Aurelien Frerou, Guillaume Louis, Gennaro De Pascale, Janneke Horn, Raimund Helbok, Guillaume Geri, Fabrice Bruneel, Ignacio Martin-Loeches, Fabio Silvio Taccone, Jan De Waele, Stephane Ruckly, Quentin Staiquly, Giuseppe Citerio, Jean-Francois Timsit, EURECA Investigator Study Grp
Summary: This study aimed to characterize the outcomes of severe meningoencephalitis patients requiring intensive care. A multicenter international cohort study was conducted from 2017 to 2020 in 68 centers across 7 countries. Among the enrolled patients, 50.5% had a poor functional outcome at 3 months, and the independent factors associated with this outcome included age > 60 years, immunodepression, delayed ICU admission, low Glasgow Coma Scale score, motor deficits, respiratory and cardiovascular complications, while administration of certain medications on ICU admission was protective.
INTENSIVE CARE MEDICINE
(2023)
Review
Medicine, Research & Experimental
Elisa B. Monteiro, Matheus Ajackson, Milena B. Stockler-Pinto, Fitsum Guebre-Egziabher, Julio B. Daleprane, Christophe O. Soulage
Summary: This review analyzed the renoprotective effects of sulforaphane (SFN) in preclinical models of kidney diseases. The results showed that SFN improved renal function, reduced kidney injury, and decreased urinary protein excretion and kidney fibrosis. These findings suggest that SFN supplementation may be a potential therapeutic strategy for kidney disease.
Article
Multidisciplinary Sciences
Yves Gouriou, Fabrice Gonnot, Mariam Wehbi, Camille Brun, Ludovic Gomez, Gabriel Bidaux
Summary: Genetically encoded biosensors based on fluorescent proteins (FPs) are widely used to monitor calcium ion (Ca2+) dynamics and sub-cellular spatial distribution in cells. The mitochondrial-associated membranes (MAMs), which connect the endoplasmic reticulum (ER) and mitochondria, have recently gained attention due to their role in calcium homeostasis and mitochondrial function. However, the sensitivity of the existing Ca2+ biosensors on the outer-mitochondrial membrane (OMM) is not sufficient to measure sub-micromolar changes in Ca2+ concentration. In this study, a new highly sensitive Ca2+ biosensor was developed and demonstrated to detect smaller differences in Ca2+ levels in or near the MAMs. Notably, the study also revealed the endogenous activity of IP3-receptors in the Ca2+ leak channel on the OMM during hypoxia or when SERCA activity is blocked.
Article
Nutrition & Dietetics
Luc Gaussens, Emmanuel Gonzalez-Bautista, Marc Bonnefoy, Marguerite Briand, Neda Tavassoli, Philipe De Souto Barreto, Yves Rolland
Summary: This study described the vitality domain of intrinsic capacity (IC) in community-dwelling older people and examined the associations of appetite and weight loss with other IC domains. The results showed that appetite and weight loss are common among older adults and are related to impairments in psychological and locomotion abilities.
Article
Hematology
Oriane Marmontel, Yara Abou-Khalil, Olivier Bluteau, Bertrand Cariou, Valerie Carreau, Sybil Charriere, Eleonore Divry, Antonio Gallo, Philippe Moulin, Francois Paillard, Noel Peretti, Jean-Pierre Rabes, Mathilde Varret, Alain Carrie, Mathilde Di Filippo
Summary: This study investigated the phenotype of 21 adult patients who carried rare LDLR and APOE variants in a French cohort. The results showed that LDLR+APOE carriers had higher blood lipid levels and a higher incidence of premature atherosclerotic cardiovascular diseases compared to LDLR carriers alone.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Rozenn Quarck, Lynn Willems, Birger Tielemans, Leanda Stoian, Alicja Ronisz, Allard Wagenaar, Frederic Perros, Guido Claessen, Agnieszka Ciarka, Laurent Godinas, Catharina Belge, Marc Jacquemin, Marion Delcroix
Summary: The crucial role of angiogenesis in clot resolution and fibrothrombotic obstruction of the pulmonary arterial bed in CTEPH was validated using a rabbit model. Inhibiting intrathrombus angiogenesis resulted in elevated pulmonary arterial pressure, increased pulmonary vascular resistance, and right ventricular hypertrophy, accompanied by pulmonary vessel remodeling and inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
