Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Brittany P. Todd, Michael S. Chimenti, Zili Luo, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Summary: The study revealed sustained, lineage-specific transcriptional changes in both microglia and astrocytes following severe TBI, with microglia showing a greater transcriptional response than astrocytes at a subacute time point. Both microglia and astrocytes were enriched for genes related to type I interferon signaling and MHC class I antigen presentation. The transcriptional response of microglia and astrocytes to severe TBI was distinct from prior reports in mild TBI and other neurodegenerative and neuroinflammatory diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Physiology
Rodrigo G. Mira, Matias Lira, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is a heterogeneous disorder that causes brain damage due to external forces, leading to CNS damage under various mechanisms. Glial cells such as astrocytes, microglia, and oligodendrocytes play crucial roles in response to TBI, affecting neuronal damage and pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Diogo Vila Verde, Marco de Curtis, Laura Librizzi
Summary: This study demonstrates that epileptiform seizure-like events can induce the activation of astrocytes and microglia, and that serum albumin extravasation exacerbates this activation, potentially leading to reinforcement of seizure activity.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Bai, Na Cui, Yucheng Liao, Chao Guo, Liang Li, Ying Yin, Aidong Wen, Jingwen Wang, Weiliang Ye, Yi Ding
Summary: Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in stroke. Danshensu (DSS) has anti-inflammatory effects, but its low cellular permeability and bioavailability limit its effectiveness. In this study, a new DSS preparation was developed using liposomes modified with phosphatidylserine (PS) and transferrin (TF) to improve the treatment of ischemic stroke. This formulation can cross the blood-brain barrier and target inflammatory glial cells, reducing inflammation and improving brain injury.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Clinical Neurology
Wasim Khan, Louise A. Corben, Hiba Bilal, Lucy Vivash, Martin B. Delatycki, Gary F. Egan, Ian H. Harding
Summary: Neuroinflammation is significantly increased in certain brain regions of individuals with FRDA, and is related to the severity, duration, and age of onset of the disease. These findings suggest that neuroimmune activity may play a role in the pathogenesis and progression of FRDA.
MOVEMENT DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Ana Belen Lopez-Rodriguez, Celine Decouty-Perez, Victor Farre-Alins, Alejandra Palomino-Antolin, Paloma Narros-Fernandez, Javier Egea
Summary: Despite numerous studies, many mechanisms underlying traumatic brain injury (TBI) remain unknown. This study investigates the role of NLRP3 inflammasome in neuroinflammation and glial response in TBI. The results highlight the importance of time-dependent activation of NLRP3 and its regulation in fine-tuning the glial response.
Article
Biochemistry & Molecular Biology
Eun Jung Park, Jihyun Je, Theodomir Dusabimana, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Elevated plasma Hcy is associated with renal dysfunction and is considered a risk factor for chronic kidney disease. Hcy treatment aggravated renal damage and enhanced inflammatory cytokines and astrocyte activation in the brain induced by IR. Lowering plasma Hcy levels may attenuate neurological dysfunction in AKI patients.
Editorial Material
Cell Biology
Eduardo R. Zimmer, Tharick A. Pascoal, Pedro Rosa-Neto, Agneta Nordberg, Luc Pellerin
Summary: This statement suggests that astrocytes play a major role in the microglia-dependent modulation of FDG-PET.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Jeremy Alloo, Ines Leleu, Corinne Grangette, Sylviane Pied
Summary: Parasitic infections can lead to brain inflammation, disrupting glial cell activity and the integrity of the blood-brain barrier. Changes in the gut microbiota may influence the severity of the central nervous system's inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Daniel J. Hellenbrand, Charles M. Quinn, Zachariah J. Piper, Carolyn N. Morehouse, Jordyn A. Fixel, Amgad S. Hanna
Summary: Traumatic spinal cord injury leads to a loss of motor and sensory function, and triggers a cascade of secondary injury responses. The inflammatory response is complex, involving a variety of cells and signaling molecules. Understanding the pathophysiology of SCI is crucial for identifying therapeutic targets to attenuate secondary damage.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Pharmacology & Pharmacy
Vaibhav Patil, Raghvendra Bohara, Vijaya Krishna Kanala, Siobhan Mcmahon, Abhay Pandit
Summary: Spinal cord injury leads to chronic inflammation and glial scar formation caused by the activation of microglia and astrocytes. Current anti-inflammatory strategies have limitations and do not consider the progression of glial cell-derived inflammation. Understanding this progression is crucial for evaluating therapeutic strategies. New models can be used as high-throughput screening platforms for novel therapeutics.
DRUG DISCOVERY TODAY
(2023)
Review
Endocrinology & Metabolism
Xiaoli Liao, Miao Chen, Yamin Li
Summary: The present study aimed to review evidence from postmortem brain and PET studies on the role of glia induced neuroinflammation in the pathogenesis of ASD. The findings from postmortem studies showed increased microglial number and density, as well as increased GFAP protein and mRNA expression in ASD subjects. However, the outcomes of PET studies were inconsistent, with one reporting increased TSPO expression and two reporting decreased TSPO expression in ASD subjects.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Cell Biology
Xia Hu, Shaojian Li, Zhongshan Shi, Wei-Jye Lin, Yuhua Yang, Yi Li, Honghong Li, Yongteng Xu, Meijuan Zhou, Yamei Tang
Summary: This study investigated the pathological role of reactive astrocytes in inflammatory response following TBI, and found that astrocytes play an important role in suppressing inflammatory responses in the injured brain.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Endocrinology & Metabolism
Fiona Brabazon, Colin M. Wilson, Shalini Jaiswal, John Reed, William H. Frey, Kimberly R. Byrnes
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Multidisciplinary Sciences
Fiona Brabazon, Sara Bermudez, Michael Shaughness, Guzal Khayrullina, Kimberly R. Byrnes
Article
Multidisciplinary Sciences
Julia H. Chariker, Cynthia Gomes, Fiona Brabazon, Kathryn A. Harman, Sujata Saraswat Ohri, David S. K. Magnuson, Scott R. Whittemore, Jeffrey C. Petruska, Eric C. Rouchka
Article
Multidisciplinary Sciences
Julia H. Chariker, Sujata Saraswat Ohri, Cynthia Gomes, Fiona Brabazon, Kathryn A. Harman, Kathryn M. DeVeau, David S. K. Magnuson, Michal Hetman, Jeffrey C. Petruska, Scott R. Whittemore, Eric C. Rouchka