Article
Cell Biology
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi
Summary: CD36 plays an important role in podocyte injury in lupus nephritis by activating NLRP3 inflammasome and inhibiting autophagy, and enhancing autophagy can decrease NLRP3 inflammasome and alleviate podocyte injury.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Lidia Sanchez-Moral, Neus Rafols, Clara Martori, Tony Paul, Erica Tellez, Maria-Rosa Sarrias
Summary: CD5L, primarily expressed and secreted by macrophages, plays a critical role in immune effector functions. In addition to its anti-apoptotic function, it is involved in pattern recognition, autophagy, cell polarization, and the regulation of lipid metabolism, influencing prevalent diseases caused by acute or chronic inflammation. This review summarizes the diverse roles of CD5L in the modulation of inflammation during infection- and sterile-driven inflammatory pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Dan Xu, Swati Bhattacharyya, Wenxia Wang, Igal Ifergan, Ming-Yi Alice Chiang Wong, Daniele Procissi, Anjana Yeldandi, Swarna Bale, Roberta Goncalves Marangoni, Craig Horbinski, Stephen D. Miller, John Varga
Summary: Systemic sclerosis (SSc) is a chronic orphan disease with a poorly understood pathogenesis. We have found that monocytes and macrophages expressing the scavenger receptor MARCO play a significant role in chronic inflammation and fibrosis in SSc. Treatment with PLG nanoparticles could effectively reduce skin and lung inflammation and fibrosis. In vitro, PLG nanoparticles inhibited TGF-dependent fibrotic responses.
Article
Cell Biology
Frances S. Li, Kathryn S. Carpentier, David W. Hawman, Cormac J. Lucas, Stephanie E. Ander, Heinz Feldmann, Thomas E. Morrison
Summary: Arboviruses are a public health threat, and this study demonstrates the role of the scavenger receptor MARCO in efficiently clearing alphaviruses from circulation. MARCO promotes binding and internalization of CHIKV, ONNV, and RRV in vitro. The species-specific effects of MARCO on CHIKV internalization suggest a potential role in determining the host's ability to amplify or clear the virus.
Article
Immunology
Nicholas A. Gherardin, Samuel J. Redmond, Hamish E. G. McWilliam, Catarina F. Almeida, Katherine H. A. Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J. Ross, Catriona Nguyen-Robertson, Shian Su, Matthew E. Ritchie, Jose A. Villadangos, D. Branch Moody, Daniel G. Pellicci, Adam P. Uldrich, Dale Godfrey
Summary: This study identified members of the CD36 family as ligands for CD1c, CD1b, and CD1d proteins, with CD36 being responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Blocking CD36 clarified the identification of CD1c-restricted T cells and enhanced the detection of CD1b- and CD1d-restricted T cells. The technique developed in this study allowed for the characterization of diverse phenotypic features, TCR repertoire, and antigen-specific subsets of CD1c-restricted T cells, facilitating further research in the biology of CD1 and human CD1-restricted T cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Silvia Acosta-Gutierrez, Diana Matias, Milagros Avila-Olias, Virginia M. Gouveia, Edoardo Scarpa, Joe Forth, Claudia Contini, Aroa Duro-Castano, Loris Rizzello, Giuseppe Battaglia
Summary: This study demonstrates that the promiscuity of a single ligand can be used to create multiplexed-multivalent carriers for phenotypic targeting. The researchers developed a theoretical model and validated it experimentally to understand the interaction between polymersomes and cell glycocalyx. They also showed that the polymersomes can be used to target monocytes in vivo due to their promiscuous interaction with certain receptors.
ACS CENTRAL SCIENCE
(2022)
Article
Cell Biology
Michelle F. Griffin, Mimi R. Borrelli, Julia T. Garcia, Michael Januszyk, Megan King, Tristan Lerbs, Lu Cui, Alessandra L. Moore, Abra H. Shen, Shamik Mascharak, Nestor M. Diaz Deleon, Sandeep Adem, Walter L. Taylor, Heather E. DesJardins-Park, Marc Gastou, Ronak A. Patel, Bryan A. Duoto, Jan Sokol, Yuning Wei, Deshka Foster, Kellen Chen, Derrick C. Wan, Geoffrey C. Gurtner, Hermann P. Lorenz, Howard Y. Chang, Gerlinde Wernig, Michael T. Longaker
Summary: Pathologic skin scarring is a significant economic and medical burden, with JUN identified as a critical regulator in initiating fibrosis by modulating CD36, a downstream effector. Targeting CD36 may represent a potential therapeutic strategy against pathological skin scarring.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sudipta Biswas, Detao Gao, Jessica B. Altemus, Umar R. Rekhi, Ellen Chang, Maria Febbraio, Tatiana V. Byzova, Eugene A. Podrez
Summary: Recent studies have shown that plasma cCD36 levels are elevated in hyperlipidemic conditions, with endothelial cells making a significant contribution. Oxidized phospholipids known to accumulate in hyperlipidemia induce the release of CD36 from various cell types. This demonstrates a link between cCD36 and oxidized phospholipids associated with oxidative stress and low-grade inflammation in hyperlipidemia.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Meiyu Cui, Xiaohong Li, Lihua Geng, Ning Wu, Jing Wang, Zhenzhen Deng, Zhi Li, Quanbin Zhang
Summary: This study compared the immunomodulatory activities of six different fucoidans from Saccharina japonica and found that the molecular weight and chemical composition of fucoidans affect their binding ability to SRs and immunomodulatory effects. Additionally, several variants of SR-A as ligands in fucoidans were confirmed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Li Zhong, Xuan Sheng, Wanbing Wang, Yanzhong Li, Rengong Zhuo, Kai Wang, Lianshuai Zhang, Dan-Dan Hu, Yujuan Hong, Linting Chen, Hengjun Rao, Tingting Li, Muyang Chen, Zhihao Lin, Yun-wu Zhang, Xin Wang, Xiao-Xin Yan, Xiaochun Chen, Guojun Bu, Xiao-Fen Chen
Summary: This study reveals that TREM2 attenuates the activation of classical complement cascade by binding to its initiator C1q, providing mechanistic insights into the protective roles of TREM2 against AD pathogenesis. The formation of TREM2-C1q complexes in the human AD brains is associated with lower C3 deposition but higher amounts of synaptic proteins. Trem2 haploinsufficiency in mice increases complement-mediated microglial engulfment of synapses and accelerates synaptic loss, while administration of a TREM2 peptide rescues synaptic impairments in AD mouse models.
Article
Medicine, Research & Experimental
Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi
Summary: Glycol-AGEs impair the innate immune response by suppressing the upstream process in TLR4 signaling, and also have a suppressive effect on STING signaling in macrophages.
Article
Optics
Shengqiang Liu, Jingxuan Du, Zhen Song, Chonggeng Ma, Quanlin Liu
Summary: The development of high-performance NIR light-emitting materials is crucial for meeting the increasing demand for high-contrast biological imaging, non-destructive testing, and infrared night vision. This study reports the first-ever NIR-II broadband luminescence based on the intervalence charge transfer (IVCT) of Cr3+-Cr3+ aggregation in gallate magentoplumbite. The application of LaMgGa11O19:0.7Cr(3+) in NIR-II biological imaging, non-destructive testing, and night vision is demonstrated, providing new insights into broadband NIR-II luminescence under UV-NIR excitation based on the IVCT of Cr3+-Cr3+ aggregation.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Cell Biology
Chenfei He, Shan Wang, Chikai Zhou, Minghui He, Jin Wang, Marcus Ladds, Danai Lianoudaki, Saikiran K. Sedimbi, David P. Lane, Lisa S. Westerberg, Shuijie Li, Mikael C. Karlsson
Summary: CD36 plays a critical role in regulating macro-autophagy in B cells, and its deficiency impairs the humoral immune response, leading to reduced plasma cell formation, mitochondrial mobilization, and oxidative phosphorylation. CD36 also regulates autophagy and is involved in T-cell-dependent immune responses.
Article
Nanoscience & Nanotechnology
Yan Zhu, Yanni Xu, Dong Han, Xiujin Zhang, Cheng Qin, Jing Liu, Lei Tian, Mengqi Xu, Yan Fang, Yang Zhang, Yabin Wang, Feng Cao
Summary: In this study, a scavenger receptors AI (SR-AI) targeted theranostic nanoparticles were constructed to target foam cells and atherosclerotic plaques via ABCA1 activation. The SAU-NPs showed more active targeting to plaque lesions compared to non-SR-AI targeted nanoparticles. SAU-NPs carrying 5242331 inhibited the transformation to foam cells and effectively reduced cholesterol deposition through activating the LXR & alpha;-ABCA1/ABCG1/SR-BI pathway.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Review
Medicine, General & Internal
Arnulfo Ramos-Jimenez, Ruth A. Zavala-Lira, Veronica Moreno-Brito, Everardo Gonzalez-Rodriguez
Summary: Fatty acid translocase/cluster of differentiation 36 (FAT/CD36) is a multifunctional membrane protein that facilitates the transport of long-chain fatty acids through cell membranes. Its expression and function can be influenced by obesity, diabetes, Single Nucleotide polymorphisms (SNPs), and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2023)