Article
Anatomy & Morphology
Simona Coviello, Yaiza Gramuntell, Patrycja Klimczak, Emilio Varea, Jose Miguel Blasco-Ibanez, Carlos Crespo, Antonio Gutierrez, Juan Nacher
Summary: This study provides evidence for the presence of immature neurons in the human brain and defines their characteristics and lineage, which is important for understanding brain development and function.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Marco Ghibaudi, Nicole Marchetti, Elena Vergnano, Chiara La Rosa, Bruno Benedetti, Sebastien Couillard-Despres, Stefano Farioli-Vecchioli, Luca Bonfanti
Summary: The recent discovery of cortical immature neurons (cINs) in the piriform cortex raises questions about their maintenance or reduction throughout the lifespan. Unlike most brain structural plasticity forms, which decline with age due to stem cell depletion, all cINs are produced during embryogenesis and retain their immaturity until they fully mature and integrate into neural circuits. This study analyzed the abundance, maturation stage, and expression of markers of maturity/immaturity in cINs in the mouse piriform cortex from postnatal to advanced ages. The results show that while the number of cINs decreases with age, a small population of highly immature cINs persists in advanced ages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Andre Steinecke, McLean M. Bolton, Hiroki Taniguchi
Summary: Interregional neuronal communication plays a crucial role in cortical circuit assembly. The cholinergic system regulates inhibitory axonal ramification in the developing neocortex by signaling through nicotinic acetylcholine receptors and T-type voltage-dependent calcium channels. Proper levels of subcortical cholinergic neuron activity are necessary for the normal development of chandelier cell axonal arbors.
Review
Anatomy & Morphology
Luca Bonfanti, Chiara La Rosa, Marco Ghibaudi, Chet C. Sherwood
Summary: Different animal species have varying degrees of neuronal plasticity. Non-mammalian vertebrates generally have adult neurogenesis, while mammals have reduced capacity for it. Comparative studies show differences in neural stem cell niches between mammalian species, with a trend of reduction from small-brained to large-brained species. However, large-brained mammals have large amounts of non-dividing immature neurons, potentially compensating for reduced adult neurogenesis in mammals.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biochemistry & Molecular Biology
Simona Coviello, Bruno Benedetti, Dominika Jakubecova, Maria Belles, Patrycja Klimczak, Yaiza Gramuntell, Sebastien Couillard-Despres, Juan Nacher
Summary: The study showed that targeted PSA enzymatic depletion in the piriform cortex of rodents accelerates the final development of immature neurons, leading to increased NeuN expression, more cells carrying an axon initial segment (AIS), and an increased number of dendrites and dendritic spines. These findings demonstrate the crucial role of PSA in the development of immature neurons outside of neurogenic niches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Anjali Gour, Kevin M. Boergens, Natalie Heike, Yunfeng Hua, Philip Laserstein, Kun Song, Moritz Helmstaedter
Summary: The study quantifies the circuit patterns of synaptogenesis for inhibitory interneurons in the developing mouse somatosensory cortex, revealing different developmental profiles and time courses for synaptic innervation of cell bodies, apical dendrites, and axon initial segments. Apical dendrites are innervated early and specifically, while axons innervating cell bodies gradually acquire specificity over time.
Article
Neurosciences
Chia-Fang Wang, Jenq-Wei Yang, Zi-Hui Zhuang, Hsiang-Wei Hsing, Heiko J. Luhmann, Shen-Ju Chou
Summary: This study revealed a bottom-up feedback mechanism for regulating the development of TCAs, which involves feedback signals from L4 neurons and the regulation by Lhx2 and Sema7a.
Article
Cell & Tissue Engineering
Madeline G. Andrews, Clara Siebert, Li Wang, Matthew L. White, Jayden Ross, Raul Morales, Megan Donnay, Gradi Bamfonga, Tanzila Mukhtar, Arpanaarjun Mckinney, Kaila Gemenes, Shaohui Wang, Qiuli Bi, Elizabeth E. Crouch, Neelroop Parikshak, Georgia Panagiotakos, Eric Huang, Aparna Bhaduri, Arnold R. Kriegstein
Summary: The differentiation of outer radial glia (oRG) cells and the production of inhibitory interneurons (INs) in the cerebral cortex are regulated by leukemia-inhibitory factor (LIF) signaling.
Review
Cell Biology
Ray Yueh Ku, Masaaki Torii
Summary: The development of the cortical in humans is a long and ongoing process, especially in adolescence where the neural circuitry continues to be modified. The corpus callosum, the largest white matter tract in the brain, has unique development features in humans, particularly with a significant increase in the number of callosal projection neurons. There are still many missing pieces in understanding the molecular controls over the development of callosal projections.
Article
Multidisciplinary Sciences
Xiangying Meng, Didhiti Mukherjee, Joseph P. Y. Kao, Patrick O. Kanold
Summary: Early sensory experience can shape subplate circuits before thalamocortical circuits to L4 mature in mice. Peripheral activity sequentially shapes cortical circuits from earlier ages than previously appreciated.
Article
Biochemistry & Molecular Biology
M. E. Maheu, S. Sharma, G. King, S. A. Maddox, A. Wingo, A. Lori, V. Michopoulos, R. Richardson, K. J. Ressler
Summary: The study indicates that doublecortin plays a significant role in fear learning and suggests that Cdk14 may serve as a predictive biomarker of trauma response.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Kevin W. Kelley, Sergiu P. Pasca
Summary: The construction of the human nervous system is a complex and regulated process. Recent advancements in genomics and stem cell-based tissue modeling have allowed for a better understanding of human neural development and dysfunction in neuropsychiatric disease.
Article
Immunology
Xing Zhou, Jiacheng Wei, Liang Li, Zhenfeng Shu, Ling You, Yang Liu, Ruozhu Zhao, Jiacheng Yao, Jianbin Wang, Minmin Luo, Yousheng Shu, Kexin Yuan, Hai Qi
Summary: Abnormalities in microglia, especially the loss of PTEN, can contribute to neurodevelopmental disorders such as autism spectrum disorders. In this study, the deletion of PTEN in microglia in mice led to deficits in sociability and object recognition. Mutant mice showed an increased number of activated microglia with enhanced phagocytosis. Interestingly, delaying the PTEN deletion in microglia for two weeks did not result in social interaction defects, although the mutant microglia remained abnormal in adult animals. The disturbed neurodevelopment caused by early PTEN deletion in microglia was characterized by decreased VGLUT1 protein in synaptosomes, which may be a consequence of enhanced removal by microglia. In vitro recordings also demonstrated weakened synaptic inputs in the developing cortex. Therefore, microglial PTEN plays a crucial role in maintaining the integrity of neural substrates underlying sociability during development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Patricia Perez-Garcia, Ricardo Pardillo-Diaz, Noelia Geribaldi-Doldan, Ricardo Gomez-Oliva, Samuel Dominguez-Garcia, Carmen Castro, Pedro Nunez-Abades, Livia Carrascal
Summary: Understanding the development of specialized neural circuits in adult mammals requires studying the changes in neuronal membrane properties and circuits during postnatal maturation. Research on layer V pyramidal neurons in the rat primary motor cortex showed that certain parameters are established at birth, while other properties continue to develop until adulthood. These modifications lead to a decrease in neuronal excitability and an increase in working range, providing more sensitive and accurate responses in young adult neurons.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Diana C. Rotaru, Ilse Wallaard, Maud de Vries, Julia van der Bie, Ype Elgersma
Summary: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by loss of functional UBE3A. This study investigated the role of UBE3A in striatal maturation and found that reinstatement of UBE3A expression in early postnatal stages can fully restore neuronal excitability but only partially restore synaptic transmission and behavioral phenotypes. These findings highlight the importance of UBE3A in striatal maturation and the need for early intervention in AS.
Article
Clinical Neurology
Ilaria Prada, Martina Gabrielli, Elena Turola, Alessia Iorio, Giulia D'Arrigo, Roberta Parolisi, Mariacristina De Luca, Marco Pacifici, Mattia Bastoni, Marta Lombardi, Giuseppe Legname, Dan Cojoc, Annalisa Buffo, Roberto Furlan, Francesca Peruzzi, Claudia Verderio
ACTA NEUROPATHOLOGICA
(2018)
Article
Biochemistry & Molecular Biology
C. Quadalti, D. Brunetti, I. Lagutina, R. Duchi, A. Perota, G. Lazzari, R. Cerutti, I. Di Meo, M. Johnson, E. Bottani, P. Crociara, C. Corona, S. Grifoni, V. Tiranti, E. Fernandez-Vizarra, A. J. Robinson, C. Viscomi, C. Casalone, M. Zeviani, C. Galli
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Neurosciences
Cecilia Mancini, Eriola Hoxha, Luisa Iommarini, Alessandro Brussino, Uwe Richter, Francesca Montarolo, Claudia Cagnoli, Roberta Parolisi, Diana Iulia Gondor Morosini, Valentina Nicolo, Francesca Maltecca, Luisa Muratori, Giulia Ronchi, Stefano Geuna, Francesca Arnaboldi, Elena Donetti, Elisa Giorgio, Simona Cavalieri, Eleonora Di Gregorio, Elisa Pozzi, Marta Ferrero, Evelise Riberi, Giorgio Casari, Fiorella Altruda, Emilia Turco, Giuseppe Gasparre, Brendan J. Battersby, Anna Maria Porcelli, Enza Ferrero, Alfredo Brusco, Filippo Tempia
NEUROBIOLOGY OF DISEASE
(2019)
Article
Neurosciences
Paola Crociaraa, Maria Novella Chieppa, Elena Vallino Costassa, Elena Berrone, Marina Gallo, Monica Lo Faro, Maria Domenica Pintore, Barbara Iulini, Antonio D'Angelo, Giovanni Perona, Alberto Botter, Donato Formicola, Alberto Rainoldi, Marianna Paulis, Paolo Vezzoni, Federica Meli, Fiorenzo Antonio Peverali, Caterina Bendotti, Maria Chiara Trolese, Laura Pasetto, Valentina Bonetto, Giovanna Lazzari, Roberto Duchi, Andrea Perota, Irma Lagutina, Corinne Quadalti, Maria Silvia Gennero, Daniela Dezzutto, Rosanna Desiato, Marina Boido, Matilde Ghibaudi, Maria Consuelo Valentini, Maria Caramelli, Cesare Galli, Cristina Casalone, Cristiano Corona
NEUROBIOLOGY OF DISEASE
(2019)
Article
Multidisciplinary Sciences
Alessandra Favole, Maria Mazza, Elena Vallino Costassa, Antonio D'Angelo, Guerino Lombardi, Paola Marconi, Paola Crociara, Elena Berrone, Marina Gallo, Claudia Palmitessa, Christina D. Orru, Byron Caughey, Pier L. Acutis, Maria Caramelli, Cristina Casalone, Cristiano Corona
SCIENTIFIC REPORTS
(2019)
Review
Medicine, General & Internal
Chiara La Rosa, Marco Ghibaudi, Luca Bonfanti
JOURNAL OF CLINICAL MEDICINE
(2019)
Review
Neurosciences
Chiara La Rosa, Roberta Parolisi, Luca Bonfanti
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Davide Marangon, Enrica Boda, Roberta Parolisi, Camilla Negri, Corinna Giorgi, Francesca Montarolo, Simona Perga, Antonio Bertolotto, Annalisa Buffo, Maria P. Abbracchio, Davide Lecca
Article
Biology
Chiara La Rosa, Francesca Cavallo, Alessandra Pecora, Matteo Chincarini, Ugo Ala, Chris G. Faulkes, Juan Nacher, Bruno Cozzi, Chet C. Sherwood, Irmgard Amrein, Luca Bonfanti
Article
Cell Biology
Marta Mellai, Laura Annovazzi, Ilaria Bisogno, Cristiano Corona, Paola Crociara, Barbara Iulini, Paola Cassoni, Cristina Casalone, Renzo Boldorini, Davide Schiffer
Article
Biochemistry & Molecular Biology
Roberta Parolisi, Francesca Montarolo, Alessandro Pini, Sabrina Rovelli, Andrea Cattaneo, Antonio Bertolotto, Annalisa Buffo, Valentina Bollati, Enrica Boda
Summary: Studies suggest that exposure to fine PM may disrupt the CNS tissue's endogenous regenerative capability, potentially contributing to demyelinating pathologies such as Multiple Sclerosis.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Chiara Furlan, Francesca Montarolo, Enza Di Gregorio, Roberta Parolisi, Sandra Atlante, Annalisa Buffo, Antonio Bertolotto, Silvio Aime, Eliana Gianolio
Summary: This study quantitatively investigated the retention of Gd in the CNS and peripheral organs of immune-mediated murine models of Multiple Sclerosis, finding a transient accumulation of Gd in the spinal cord and a potential association of Gd retention in the brain with inflammation rather than demyelination.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Enrica Boda, Martina Lorenzati, Roberta Parolisi, Brian Harding, Gianmarco Pallavicini, Luca Bonfanti, Amanda Moccia, Stephanie Bielas, Ferdinando Di Cunto, Annalisa Buffo
Summary: Depending on their distinct developmental origins and ability to counteract oxidative stress, dorsal and ventral oligodendrocyte progenitor cells of the postnatal mouse brain are differentially vulnerable to DNA damage.
NATURE COMMUNICATIONS
(2022)