Review
Cell Biology
Leyla Anne Akay, Audrey H. Effenberger, Li-Huei Tsai
Summary: Oligodendrocyte precursor cells (OPCs) are not only involved in myelination, but also form synapses with neurons, support blood-brain barrier integrity, and play a role in neuroinflammation. Sex and age may influence OPC activity, and OPC dysfunction may play a primary role in various neurological and neuropsychiatric diseases.
GENES & DEVELOPMENT
(2021)
Review
Neurosciences
Christophe Galichet, Richard W. Clayton, Robin Lovell-Badge
Summary: Oligodendrocyte progenitor cells (OPCs), also known as NG2-glia, play diverse roles in the adult central nervous system, such as serving as progenitors for oligodendrocytes, regulating metabolic environment, maintaining the blood-brain barrier, and modulating inflammation. Advanced techniques have uncovered functional and spatial heterogeneity of OPCs, interactions with other cell types, and responses to signals from neighboring cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jelena Medved, William M. Wood, Michael D. van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L. Wright, Akiko Nishiyama
Summary: Oligodendrocyte precursor cells play a crucial role in brain development and have the potential to be targeted for the treatment of brain tumors.
Article
Cell Biology
Masahiro Otsu, Zubair Ahmed, Daniel Fulton
Summary: A simple method was developed to generate immature oligodendrocyte lineage cells from mouse ESC-derived neural stem cells, which showed potential for differentiation into mature OPC under specific conditions. Interestingly, these cells retained multipotentiality and could differentiate into neurons or astrocytes. However, their efficiency in myelinating axons was lower compared to primary OPC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Friederike Pfeiffer
Summary: Oligodendrocyte precursor cells have the capability to differentiate into oligodendrocytes and myelinate axons, but they also frequently interact with cells of the neurovascular unit. The consequences of these interactions are not yet clear, but are being increasingly studied. Despite their apparent homogeneity, OPCs have the potential to adapt to their microenvironment. This review summarizes the various roles of OPC-vascular interactions and the circumstances under which they have been observed.
Article
Neurosciences
Chunxia Jiang, Wanwan Qiu, Yingying Yang, Hao Huang, Zhong-min Dai, Aifen Yang, Tao Tang, Xiaofeng Zhao, Mengsheng Qiu
Summary: In this study, it was discovered that NG2 proteoglycan can bind to PDGF-AA, enhancing PDGFRa signaling. Furthermore, the Adamts4 enzyme cleaves NG2 protein during the differentiation stage, with Adamts4 deficiency leading to impaired oligodendrocyte differentiation and axonal myelination. Additionally, Adamts4 deficiency also reduces myelin repair in the adult brain tissue. Overall, Adamts4 could be targeted for potential therapeutic strategies in demyelinating diseases.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Tess Dierckx, Sam Vanherle, Mansour Haidar, Elien Grajchen, Fleur Mingneau, Pascal Gervois, Esther Wolfs, Dany Bylemans, Arnout Voet, Tien Nguyen, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Summary: This study reveals the reasons for the failure of remyelination, including the overly inflammatory microenvironment and the intrinsic inability of oligodendrocyte precursor cells to differentiate. The study also shows that phloretin can significantly promote remyelination by acting on the nuclear receptor peroxisome proliferator-activated receptor gamma to promote the maturation of oligodendrocyte precursor cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Akiko Nishiyama, David R. Serwanski, Friederike Pfeiffer
Summary: Oligodendrocyte precursor cells are a unique cell population in the central nervous system, capable of generating new oligodendrocytes throughout life. Recent studies suggest potential new roles for these cells in certain pathological conditions.
Article
Medicine, Research & Experimental
Haipeng Zhou, Ying He, Zhaoyan Wang, Qian Wang, Caiyan Hu, Xiaohua Wang, Siliang Lu, Ke Li, Yinxiang Yang, Zuo Luan
Summary: NG2+ and A2B5+ cells have poor myelination ability due to low levels of PDGFR-alpha+ cells. Thus, hOPCs with a higher content of PDGFR-alpha+ cells may be more effective in cell transplantation for demyelinating diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
JoAnn Buchanan, Leila Elabbady, Forrest Collman, Nikolas L. Jorstad, Trygve E. Bakken, Carolyn Ott, Jenna Glatzer, Adam A. Bleckert, Agnes L. Bodor, Derrick Brittain, Daniel J. Bumbarger, Gayathri Mahalingam, Sharmishtaa Seshamani, Casey Schneider-Mizell, Marc M. Takeno, Russel Torres, Wenjing Yin, Rebecca D. Hodge, Manuel Castro, Sven Dorkenwald, Dodam Ih, Chris S. Jordan, Nico Kemnitz, Kisuk Lee, Ran Lu, Thomas Macrina, Shang Mu, Sergiy Popovych, William M. Silversmith, Ignacio Tartavull, Nicholas L. Turner, Alyssa M. Wilson, William Wong, Jingpeng Wu, Aleksandar Zlateski, Jonathan Zung, Jennifer Lippincott-Schwartz, Ed S. Lein, H. Sebastian Seung, Dwight E. Bergles, R. Clay Reid, Nuno Macarico da Costa
Summary: Neurons in the developing brain undergo structural refinement through the engulfment and degradation of axonal branches and synapses by glial cells. In the mouse visual cortex, oligodendrocyte precursor cells (OPCs) were found to surround small branches of axons and engage in axon pruning. Compared to microglia, OPCs were more abundant in phagosomes and phagolysosomes, suggesting their substantial contribution to neuronal circuit refinement during cortical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Federica Cherchi, Anna Maria Pugliese, Elisabetta Coppi
Summary: Oligodendrocyte-formed myelin sheaths facilitate fast synaptic transmission in the brain, but their degeneration can lead to demyelinating diseases. Remyelination relies on the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes, with the neuromodulator adenosine and its receptors playing crucial roles in this process. The review highlights the potential therapeutic targets in demyelinating pathologies like multiple sclerosis by targeting adenosine receptor ligands.
NEURAL REGENERATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Wen Liu, Aaron R. Rohlman, Ryan Vetreno, Fulton T. Crews
Summary: The study found that adolescent binge drinking affects adult OL markers in PFC regions, while also impacting OPC marker expression; furthermore, these effects could lead to lasting changes in PFC function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yohan S. S. Auguste, Austin Ferro, Jessica A. Kahng, Andre M. Xavier, Jessica R. Dixon, Uma Vrudhula, Anne-Sarah Nichitiu, Daniele Rosado, Tse-Luen Wee, Ullas Pedmale, Lucas Cheadle
Summary: Oligodendrocyte precursor cells contribute to the elimination of thalamocortical presynapses in response to sensory experience.
NATURE NEUROSCIENCE
(2022)
Review
Neurosciences
Lucila Perez-Gianmarco, Begum Kurt, Maria Kukley
Summary: This review focuses on the technical approaches used to study AMPARs in oligodendrocyte lineage cells and discusses future perspectives for AMPAR research in glial cells.
Review
Biochemistry & Molecular Biology
Sayan Chakraborty, Sayantani Sinha, Amitava Sengupta
Summary: The integration of epigenetic regulation with transcriptional and cell signaling machinery plays a crucial role in determining tissue resident adult pluripotent mesenchymal stem/stromal cell (MSC) activity, lineage commitment, and immunomodulation. Histone modifying enzymes and chromatin remodeling complexes are central features influencing gene regulation and tissue identity establishment in MSCs. Modulation of transcription factor expression gradient and flexibility of chromatin architecture are exciting approaches to regulate MSC activity.
Article
Rheumatology
Taro Kasai, Gen Momoyama, Yuichi Nagase, Tetsuro Yasui, Sakae Tanaka, Takumi Matsumoto
Summary: This study suggests that disease activity has an impact on recurrent deformities of the lesser toes in patients with rheumatoid arthritis after resection arthroplasty for forefoot deformities, while recurrent deformities of the hallux are associated with the severity of preoperative hallux deformity.
MODERN RHEUMATOLOGY
(2021)
Review
Endocrinology & Metabolism
Sakae Tanaka, Yoshiya Tanaka
Summary: RANKL plays a critical role in rheumatoid arthritis, with Denosumab being an effective therapeutic option.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Clinical Neurology
Koji Nakajima, Hideki Nakamoto, So Kato, Toru Doi, Yoshitaka Matsubayashi, Yuki Taniguchi, Yuichi Yoshida, Naohiro Kawamura, Hiroyuki Nakarai, Akiro Higashikawa, Keiichiro Tozawa, Yujiro Takeshita, Masayoshi Fukushima, Masaaki Iizuka, Takashi Ono, Tomohiko Shirokoshi, Seiichi Azuma, Sakae Tanaka, Yasushi Oshima
Summary: C2-C3 bony fusion occurred more often in the C3 laminoplasty group compared to the C3 laminectomy group. However, there were no significant differences between the two groups in terms of patient-reported outcomes, neck pain, satisfaction, and other clinical measures.
CLINICAL SPINE SURGERY
(2021)
Article
Multidisciplinary Sciences
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Yasuhiro Sawada, Ryohei Nishimura, Naoki Fujita
Summary: Early administration of escitalopram after spinal cord injury effectively prevented the onset of spastic behaviors through modulation of the 5-HT system, but did not impact exaggerated spinal reflexes. This suggests a novel application of SSRIs for preventative treatment of spasticity.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Haruko Watanabe-Takano, Hiroki Ochi, Ayano Chiba, Ayaka Matsuo, Yugo Kanai, Shigetomo Fukuhara, Naoki Ito, Keisuke Sako, Takahiro Miyazaki, Kazuki Tainaka, Ichiro Harada, Shingo Sato, Yasuhiro Sawada, Naoto Minamino, Shu Takeda, Hiroki R. Ueda, Akihiro Yasoda, Naoki Mochizuki
Summary: This study identified OSTN as a mechanotransducer for load-induced long bone growth, enhancing CNP-dependent proliferation and maturation of chondrocytes. OSTN cooperates with CNP to regulate bone formation, preventing NPR3-mediated clearance of CNP and facilitating CNP-signal-mediated bone growth.
Article
Multidisciplinary Sciences
Takahiro Maekawa, Naoyoshi Sakitani, Youngjae Ryu, Atsushi Takashima, Shuhei Murase, Julius Fink, Motoshi Nagao, Toru Ogata, Masahiro Shinohara, Yasuhiro Sawada
Summary: Exercise is effective for brain dysfunction, but the molecular mechanisms behind it are poorly understood. A custom-designed system was developed to simulate mechanical stimulation experienced by rodents during treadmill running. The study found that this stimulation affects the 5-HT2A signaling in the brain. The research provides detailed protocols for using this system in experiments.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Multidisciplinary Sciences
Takehiro Matsubara, Kazuhito Soma, Ikufumi Yamada, Hiroshi Fujita, Junya Yoshitani, Hiroyuki Oka, Hiroyuki Okada, Sakae Tanaka
Summary: Surgery for intertrochanteric fractures using intramedullary hip nails with an anterior offset (Best Fit Nail) has been found to be more effective in maintaining fragment reduction and proper lag screw position compared with conventional non-offset nails (Proximal Femoral Nail Antirotation), according to postoperative computed tomography evaluation.
Article
Medicine, General & Internal
Takuya Kawahara, Keiko Yamada, Ryohei Terashima, Ikumi Takashima, Sakae Tanaka, Toru Ogata, Hirotaka Chikuda, Hiromasa Miura, Kozo Nakamura, Takashi Ohe
Summary: Multiple imputation was found to be the preferable method for handling missing values in the GLFS-25 questionnaire. However, single imputation using subject average/subject domain average can be used with practically negligible bias as long as the number of missing items is up to 8 out of 25 items in each individual of the population.
Article
Rheumatology
Tsutomu Takeuchi, Sakae Tanaka, Mitsuru Murata, Yoshiya Tanaka
Summary: This study aimed to evaluate the efficacy and safety of TAS5315 in Japanese patients with refractory rheumatoid arthritis. The results showed numerical differences in disease activity improvement rates between the TAS5315 group and the placebo group at week 12, but the primary endpoint was not achieved. However, TAS5315 demonstrated advantages in disease activity and biomarker improvement, as well as higher risk of bleeding events within 36 weeks. Therefore, a risk-benefit analysis of TAS5315 should be considered.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ryutaro Takeda, Takumi Matsumoto, Yasunori Omata, Hiroshi Inui, Shuji Taketomi, Yuichi Nagase, Takuji Nishikawa, Hiroyuki Oka, Sakae Tanaka
Summary: This study investigated the trend of joint destruction patterns on knee radiographs of patients with rheumatoid arthritis (RA) undergoing total knee arthroplasty (TKA) over the past 16 years. The results showed that radiographs of TKA recipients with RA are increasingly presenting osteoarthritic features in recent decades. The study also identified different clusters based on radiographic findings, indicating variations in joint space narrowing, spur formation, and alignment.
CLINICAL RHEUMATOLOGY
(2023)
Article
Engineering, Biomedical
Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, Takuya Kishi, Yuki Yoshikawa, Takamasa Sakai, Makoto Ayaori, Hirohiko Inanami, Koji Tomiyasu, Atsushi Takashima, Toru Ogata, Hirotsugu Tsuchimochi, Shinya Sato, Shigeyoshi Saito, Kohzoh Yoshino, Yuiko Matsuura, Kenichi Funamoto, Hiroki Ochi, Masahiro Shinohara, Motoshi Nagao, Yasuhiro Sawada
Summary: Vertically oscillating head motions can reduce blood pressure in hypertensive individuals, possibly by reducing the expression of angiotensin II type-1 receptor in astrocytes. This suggests that mechanical interventions could be used to elicit antihypertensive effects.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Orthopedics
H. Kobayashi, N. Ito, Y. Nakai, H. Katoh, K. Okajima, L. Zhang, Y. Tsuda, S. Tanaka
Summary: The aim of this study was to report the patterns of symptoms and insufficiency fractures in patients with tumour-induced osteomalacia (TIO) for early diagnosis. The study included 33 TIO patients treated between January 2000 and June 2022. Symptoms and radiological patterns of insufficiency fractures were investigated. The results showed that TIO patients experienced back pain, chest wall pain, and hip pain, with vertebral fractures being biconcave deformities and periarticular fractures involving subchondral insufficiency fractures and epiphyseal or metaphyseal fractures. The presence of these symptoms and insufficiency fractures in patients with a tumor should suggest TIO diagnosis.
BONE & JOINT JOURNAL
(2023)
Article
Cell & Tissue Engineering
Takeshi Oichi, Joe Kodama, Kimberly Wilson, Hongying Tian, Yuka Imamura Kawasawa, Yu Usami, Yasushi Oshima, Taku Saito, Sakae Tanaka, Masahiro Iwamoto, Satoru Otsuru, Motomi Enomoto-Iwamoto
Summary: Long bone growth in the growth plate relies on endochondral ossification through the accumulation and synthesis of matrix scaffold by chondrocytes. Nutritional restriction increases the number of chondroprogenitors in the resting zone and inhibits their differentiation, while nutrient recovery promotes their differentiation and contributes to accelerated growth. Furthermore, the phosphorylation of Akt in the resting zone is reduced under nutrient deprivation, and exogenous IGF-1 restores the phosphorylation of Akt and stimulates the differentiation of chondroprogenitor cells, leading to a decrease in their numbers.
Article
Endocrinology & Metabolism
Yasunori Omata, Hiroyuki Okada, Steffen Uebe, Naohiro Izawa, Arif B. Ekici, Kerstin Sarter, Taku Saito, Georg Schett, Sakae Tanaka, Mario M. Zaiss
Summary: Bone turnover is regulated by a variety of bone cells, including osteoblasts, osteoclasts, and osteocytes. The differentiation and maturation of osteoclasts are crucial for maintaining skeletal homeostasis. Through single-cell RNA sequencing, researchers identified RAB38 as a key molecule involved in osteoclast differentiation and maturation.
Article
Endocrinology & Metabolism
Hisato Watanabe, Hiroyuki Okada, Jun Hirose, Yasunori Omata, Takumi Matsumoto, Morio Matsumoto, Masaya Nakamura, Taku Saito, Takeshi Miyamoto, Sakae Tanaka
Summary: We investigated the role of hematopoietically expressed homeobox protein (Hhex) in osteoclast development. Our findings suggest that Hhex acts as an inhibitor of osteoclast differentiation through epigenetic regulation and modulation of the cell cycle of osteoclast precursors. Hhex expression is reduced during RANKL-induced osteoclastogenesis, and overexpression or suppression of Hhex affects the development of osteoclasts in vitro. Conditional deletion of Hhex in osteoclast-lineage cells promotes osteoclastogenesis and reduces cancellous bone volume in mice.