Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Endocrinology & Metabolism
Ke-Qin Zeng, Fang-Yuan Gong, Xiao-Hua Pan, Jie Miao, Zheng Gong, Jun Wang, Qiao Zhong, Xia-Qiu Dai, Xiao-Ming Gao
Summary: The study demonstrates that IgG immunocomplexes can drive the differentiation of human blood monocytes into nonclassical osteoclasts independent of RANKL and inflammatory cytokines, and can also reverse classical osteoclast differentiation induced by RANKL in vitro. This finding may provide an explanation for the uncoupling of cartilage destruction and bone erosion in autoinflammatory arthritis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
X. H. Kong, S. F. Shi, H. J. Hu, J. X. Wang
Summary: The study reveals that the expression of miR-20a is decreased in RA mice, and it inhibits the proliferation and differentiation of osteoclasts by partly targeting the TLR4/p38 pathway. This work provides evidence that miR-20a hinders osteoclast proliferation and differentiation by targeting RANKL through the TLR4/p38 pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Orthopedics
Chaoming Huang, Yufan Zheng, Jinyu Bai, Ce Shi, Xin Shi, Huajian Shan, Xiaozhong Zhou
Summary: The study found that HGF is overexpressed in RA patients and CIA mice, and it regulates osteoclastogenesis through the JNK and AKT-GSK-3 beta-NFATc1 signaling pathways. Inhibition of HGF/c-Met effectively alleviated bone loss in RA, suggesting its potential as a new target for treating bone loss in RA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Multidisciplinary Sciences
Daichi Akasaka, Satoru Iguchi, Ryusuke Kaneko, Yohei Yoshiga, Daisuke Kajiwara, Yoshinori Nakachi, Naruto Noma, Kenji Tanaka, Atsushi Shimizu, Fumihito Hosoi
Summary: The study investigated the potential of a Bruton's tyrosine kinase inhibitor, TAS5315, in treating rheumatoid arthritis. The results showed that TAS5315 suppressed immune-related signaling pathways, reduced inflammation, improved bone density, and ameliorated pathological changes in arthritis models, suggesting its promising therapeutic effects.
Article
Immunology
Orsolya Tuende Kovacs, Eszter Toth, Oliver Ozohanics, Eszter Soltesz-Katona, Nikolett Marton, Edit Iren Buzas, Laszlo Hunyady, Laszlo Drahos, Gabor Turu, Gyorgy Nagy
Summary: This study investigated the proteomic changes during osteoclast differentiation in healthy donors, RA, and PsA. The results showed increased expression of proteins involved in metabolic activity, secretory function, and cell polarity during differentiation, while immune signaling pathways were downregulated. The expression differences between healthy donors and RA/PsA patients were most noticeable after the final steps of differentiation. The study provides important insights into the pathophysiology of RA and PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Shu-jun Wei, Qing Zhang, Yong-jing Xiang, Lan-yu Peng, Wei Peng, Qiang Ren, Yong-xiang Gao
Summary: Guizhi-Shaoyao-Zhimu decoction has shown anti-rheumatoid arthritis effects in CII-induced arthritis rats, suggesting its potential use as a supplement and alternative drug therapy for RA.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Oncology
Junjie Lu, Desheng Hu, Yan Zhang, Chen Ma, Lin Shen, Bo Shuai
Summary: Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits bone resorption by competitively binding with RANKL and blocking the activation of the RANK/RANKL/OPG signaling pathway. It is used to treat metabolic bone diseases and has potential in the treatment of osteoarthritis, bone tumors, and other autoimmune diseases. However, more research is needed to understand its mechanism of action and optimize its clinical use for bone metastasis of malignant tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kazuhiro Maeda, Ken Yoshida, Tetsuro Nishizawa, Kazuhiro Otani, Yu Yamashita, Hinako Okabe, Yuka Hadano, Tomohiro Kayama, Daitaro Kurosaka, Mitsuru Saito
Summary: Rheumatoid arthritis is an inflammatory disease characterized by polyarthritis, leading to irreversible bone and joint destruction and physical disabilities. Preventing the progression of bone and joint destruction is crucial, and recent studies have shed light on its molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Seyeon Bae, Kibyeong Kim, Keunsoo Kang, Haemin Kim, Minjoon Lee, Brian Oh, Kaichi Kaneko, Sungkook Ma, Jae Hoon Choi, Hojoong Kwak, Eun Young Lee, Sung Ho Park, Kyung-Hyun Park-Min
Summary: Monocyte/macrophage lineage cells are capable of differentiating into various cells. RANKL induces the differentiation of monocyte/macrophage lineage into bone-resorbing osteoclasts. However, the epigenetic mechanisms underlying this differentiation process in human osteoclasts are not well understood.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Melanie Aureal, Irma Machuca-Gayet, Fabienne Coury
Summary: Rheumatoid arthritis is characterized by chronic synovial inflammation and irreversible bone erosions. Osteoclast-mediated bone resorption is the main cause of articular bone erosions, with autoantibodies, pro-inflammatory cytokines, and other regulating factors playing important roles in this process.
Article
Multidisciplinary Sciences
Yuli Cheng, Yan Yu, Qinghui Zhuang, Lei Wang, Bin Zhan, Suqin Du, Yiqi Liu, Jingjing Huang, Junfeng Hao, Xinping Zhu
Summary: Helminths and their products can attenuate bone erosion by inhibiting inflammation and osteoclastogenesis through suppressing M1 polarization and related proinflammatory cytokine production, as well as inhibiting the NF-kappa B pathway.
Review
Medicine, General & Internal
Bernardo D'Onofrio, Michele di Lernia, Ludovico De Stefano, Serena Bugatti, Carlomaurizio Montecucco, Laura Bogliolo
Summary: Despite adequate control of the disease, reduction of bone mineral density and fragility fractures remain major sources of morbidity in rheumatoid arthritis patients. Autoantibodies, particularly anti-citrullinated protein antibodies, play a significant role in causing bone loss. Combining anti-RANKL therapy with conventional synthetic or biologic disease-modifying anti-rheumatic drugs may be beneficial in preventing fractures and structural damage in patients at risk of radiographic progression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
Summary: The translation discusses the role of osteoclasts in bone development and remodeling, as well as the significance of epigenetic regulation and microRNAs in gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ayda Henriques Schneider, Thaise Mayumi Taira, Gabriel Azevedo Publio, Douglas da Silva Prado, Paula Barbim Donate Yabuta, Jessica Cristina dos Santos, Caio Cavalcante Machado, Flavio Falcao Lima de Souza, Lucas Gabriel Rodrigues Venturini, Rene Donizeti Ribeiro de Oliveira, Thiago Mattar Cunha, Jose Carlos Alves-Filho, Paulo Louzada-Junior, Tarcilia Aparecida da Silva, Sandra Yasuyo Fukada, Fernando Queiroz Cunha
Summary: The study found that patients with rheumatoid arthritis had higher levels of NETs in synovial fluid, and inhibiting NETs could be a potential strategy to reduce bone erosion in arthritis patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Orthopedics
Kenichi Kono, Hiroshi Inui, Tetsuya Tomita, Takaharu Yamazaki, Shuji Taketomi, Sakae Tanaka
Summary: This study aimed to evaluate the in vivo kinematics of BCR-TKA with an anatomical articular surface during high-flexion activities. The results showed that knee kinematics varied depending on the activity, with certain patterns observed during squatting and cross-legged sitting motions.
JOURNAL OF KNEE SURGERY
(2021)
Article
Rheumatology
Taro Kasai, Gen Momoyama, Yuichi Nagase, Tetsuro Yasui, Sakae Tanaka, Takumi Matsumoto
Summary: This study suggests that disease activity has an impact on recurrent deformities of the lesser toes in patients with rheumatoid arthritis after resection arthroplasty for forefoot deformities, while recurrent deformities of the hallux are associated with the severity of preoperative hallux deformity.
MODERN RHEUMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Sakae Tanaka, Hideki Mizutani, Eri Tsuruya, Ryoko Fukuda, Kiyoka Kuge, Naoki Okubo
Summary: The study confirmed the long-term safety and effectiveness of denosumab in Japanese patients with osteoporosis in daily clinical practice. It showed significant improvements in bone density and reductions in bone turnover markers, with a low incidence of osteoporotic fractures over 3 years. No new safety signals were identified.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Rheumatology
Uchio Akihiro, Takumi Matsumoto, Yuji Maenohara, Yasunori Omata, Hiroshi Takahashi, Mitsuyasu Iwasawa, Takuo Juji, Ichiro Nakamura, Sakae Tanaka
Summary: The study found that tofacitinib did not suppress the postoperative increase in body temperature and CRP level, but may lead to a decrease in lymphocyte count. The timing for resuming tofacitinib treatment after surgery should be carefully considered.
CLINICAL RHEUMATOLOGY
(2021)
Correction
Rheumatology
Akihiro Uchio, Takumi Matsumoto, Yuji Maenohara, Yasunori Omata, Hiroshi Takahashi, Mitsuyasu Iwasawa, Takuo Juji, Ichiro Nakamura, Sakae Tanaka
CLINICAL RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Takehiro Matsubara, Kazuhito Soma, Ikufumi Yamada, Hiroshi Fujita, Junya Yoshitani, Hiroyuki Oka, Hiroyuki Okada, Sakae Tanaka
Summary: Surgery for intertrochanteric fractures using intramedullary hip nails with an anterior offset (Best Fit Nail) has been found to be more effective in maintaining fragment reduction and proper lag screw position compared with conventional non-offset nails (Proximal Femoral Nail Antirotation), according to postoperative computed tomography evaluation.
Article
Medicine, General & Internal
Takuya Kawahara, Keiko Yamada, Ryohei Terashima, Ikumi Takashima, Sakae Tanaka, Toru Ogata, Hirotaka Chikuda, Hiromasa Miura, Kozo Nakamura, Takashi Ohe
Summary: Multiple imputation was found to be the preferable method for handling missing values in the GLFS-25 questionnaire. However, single imputation using subject average/subject domain average can be used with practically negligible bias as long as the number of missing items is up to 8 out of 25 items in each individual of the population.
Article
Rheumatology
Tsutomu Takeuchi, Sakae Tanaka, Mitsuru Murata, Yoshiya Tanaka
Summary: This study aimed to evaluate the efficacy and safety of TAS5315 in Japanese patients with refractory rheumatoid arthritis. The results showed numerical differences in disease activity improvement rates between the TAS5315 group and the placebo group at week 12, but the primary endpoint was not achieved. However, TAS5315 demonstrated advantages in disease activity and biomarker improvement, as well as higher risk of bleeding events within 36 weeks. Therefore, a risk-benefit analysis of TAS5315 should be considered.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ryutaro Takeda, Takumi Matsumoto, Yasunori Omata, Hiroshi Inui, Shuji Taketomi, Yuichi Nagase, Takuji Nishikawa, Hiroyuki Oka, Sakae Tanaka
Summary: This study investigated the trend of joint destruction patterns on knee radiographs of patients with rheumatoid arthritis (RA) undergoing total knee arthroplasty (TKA) over the past 16 years. The results showed that radiographs of TKA recipients with RA are increasingly presenting osteoarthritic features in recent decades. The study also identified different clusters based on radiographic findings, indicating variations in joint space narrowing, spur formation, and alignment.
CLINICAL RHEUMATOLOGY
(2023)
Article
Orthopedics
H. Kobayashi, N. Ito, Y. Nakai, H. Katoh, K. Okajima, L. Zhang, Y. Tsuda, S. Tanaka
Summary: The aim of this study was to report the patterns of symptoms and insufficiency fractures in patients with tumour-induced osteomalacia (TIO) for early diagnosis. The study included 33 TIO patients treated between January 2000 and June 2022. Symptoms and radiological patterns of insufficiency fractures were investigated. The results showed that TIO patients experienced back pain, chest wall pain, and hip pain, with vertebral fractures being biconcave deformities and periarticular fractures involving subchondral insufficiency fractures and epiphyseal or metaphyseal fractures. The presence of these symptoms and insufficiency fractures in patients with a tumor should suggest TIO diagnosis.
BONE & JOINT JOURNAL
(2023)
Article
Cell & Tissue Engineering
Takeshi Oichi, Joe Kodama, Kimberly Wilson, Hongying Tian, Yuka Imamura Kawasawa, Yu Usami, Yasushi Oshima, Taku Saito, Sakae Tanaka, Masahiro Iwamoto, Satoru Otsuru, Motomi Enomoto-Iwamoto
Summary: Long bone growth in the growth plate relies on endochondral ossification through the accumulation and synthesis of matrix scaffold by chondrocytes. Nutritional restriction increases the number of chondroprogenitors in the resting zone and inhibits their differentiation, while nutrient recovery promotes their differentiation and contributes to accelerated growth. Furthermore, the phosphorylation of Akt in the resting zone is reduced under nutrient deprivation, and exogenous IGF-1 restores the phosphorylation of Akt and stimulates the differentiation of chondroprogenitor cells, leading to a decrease in their numbers.
Article
Endocrinology & Metabolism
Yasunori Omata, Hiroyuki Okada, Steffen Uebe, Naohiro Izawa, Arif B. Ekici, Kerstin Sarter, Taku Saito, Georg Schett, Sakae Tanaka, Mario M. Zaiss
Summary: Bone turnover is regulated by a variety of bone cells, including osteoblasts, osteoclasts, and osteocytes. The differentiation and maturation of osteoclasts are crucial for maintaining skeletal homeostasis. Through single-cell RNA sequencing, researchers identified RAB38 as a key molecule involved in osteoclast differentiation and maturation.
Article
Endocrinology & Metabolism
Hisato Watanabe, Hiroyuki Okada, Jun Hirose, Yasunori Omata, Takumi Matsumoto, Morio Matsumoto, Masaya Nakamura, Taku Saito, Takeshi Miyamoto, Sakae Tanaka
Summary: We investigated the role of hematopoietically expressed homeobox protein (Hhex) in osteoclast development. Our findings suggest that Hhex acts as an inhibitor of osteoclast differentiation through epigenetic regulation and modulation of the cell cycle of osteoclast precursors. Hhex expression is reduced during RANKL-induced osteoclastogenesis, and overexpression or suppression of Hhex affects the development of osteoclasts in vitro. Conditional deletion of Hhex in osteoclast-lineage cells promotes osteoclastogenesis and reduces cancellous bone volume in mice.
Article
Rheumatology
Haruka Tsuchiya, Mineto Ota, Shuji Sumitomo, Kazuyoshi Ishigaki, Akari Suzuki, Toyonori Sakata, Yumi Tsuchida, Hiroshi Inui, Jun Hirose, Yuta Kochi, Yuho Kadono, Katsuhiko Shirahige, Sakae Tanaka, Kazuhiko Yamamoto, Keishi Fujio
Summary: Objectives: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation in the synovium, where synovial fibroblasts (SFs) play a major role. This study aimed to understand the genetic contribution to molecular regulatory networks in SFs under inflammatory conditions. Methods: SFs from RA and osteoarthritis (OA) patients were stimulated with various cytokines and immune cell subsets were analyzed. Integrative analyses including mRNA expression, histone modifications, 3D genome architecture, and genetic variations were performed. Results: Unstimulated SFs from RA patients showed differences in transcriptome and epigenome compared to OA SFs. Most responses to stimulations were shared between the diseases. SFs expressed pathogenic genes and chromatin remodeling in activated SFs revealed enrichment of RA risk loci in clusters of enhancers induced by proinflammatory cytokines. A RA risk SNP formed 3D contact with the promoter of a gene related to arthritis, and inhibition of this gene suppressed cytokine and chemokine production in SFs. Conclusions: This study identified potential therapeutic targets associated with genetic risk of RA and established a dynamic landscape of activated SFs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)