Review
Immunology
Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wang
Summary: Recent studies have shown that the excessive activation of microglia and release of pro-inflammatory cytokines play crucial roles in the pathogenesis and progression of Parkinson's disease (PD). The elevated level of NLRP3 inflammasome in activated microglia in the substantia nigra of PD patients exacerbates the pathology and accelerates disease progression. Current therapeutic drugs for PD primarily focus on relieving clinical symptoms, as there are no established strategies to stop or reverse the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Qiu-Qin Han, Weidong Le
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopamine neurons and the formation of Lewy bodies. Alpha-synuclein and the NLRP3 inflammasome play crucial roles in neuroinflammation in PD. Understanding the molecular mechanisms and targeting strategies of the NLRP3 inflammasome may contribute to the development of effective therapies for PD.
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Xiao-Li Si, Yuan-Jian Fang, Ling-Fei Li, Lu-Yan Gu, Xin-Zhen Yin, Jun-Tian, Ya-Ping Yan, Jia-Li Pu, Bao-Rong Zhang
Summary: The study discusses the involvement of NLRP3 inflammasome in microvesicle generation and alpha-synuclein transmission in microglial cells, which could potentially lead to novel drug targets and further research in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Immunology
Adrianne F. Pike, Francesca Longhena, Gaia Faustini, Jean-Marc Van Eik, Iris Gombert, Maaike A. C. Herrebout, Mona M. H. E. Fayed, Michele Sandre, Tatiana Varanita, Charlotte E. Teunissen, Jeroen J. M. Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacco
Summary: This study reveals that dopamine inhibits the activation of NLRP3 inflammasome in primary human microglia, providing insights into the potential therapeutic target for Parkinson's disease.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jung
Summary: The study reveals that amyloid-beta activates the NLRP3 inflammasome in microglia by activating Syk and inhibiting AMPK, leading to neuroinflammation. Additionally, flufenamic acid (FA), a non-steroidal anti-inflammatory drug, effectively inhibits microglial activation of the NLRP3 inflammasome by regulating Syk and AMPK, offering a potential treatment for AD.
Article
Neurosciences
Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutierrez de Rave, Dick Terwel, Astrid Bottelbergs, Ilse Dewachter
Summary: This study reveals the significant role of NLRP3 inflammasome in Alzheimer's disease and related tauopathies, with implications for both tau-associated neurodegeneration and tau propagation.
Review
Cell Biology
Fillipe M. de Araujo, Lorena Cuenca-Bermejo, Emiliano Fernandez-Villalba, Silvia L. Costa, Victor Diogenes A. Silva, Maria Trinidad Herrero
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor symptoms, with pre-motor symptoms potentially preceding them. While the clinical characteristics of PD are well-defined, its pathogenesis is not fully understood, with inflammation and microglial activation believed to play key roles.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
William S. Dodd, Imaray Noda, Melanie Martinez, Koji Hosaka, Brian L. Hoh
Summary: The study identified the role of NLRP3 in different phases following SAH, demonstrating that NLRP3 inhibition can improve neuroinflammation and cerebrovascular dysfunction caused by SAH. Furthermore, the research suggests that NLRP3 inhibitors could be promising tools in the treatment of EBI and DCI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Neurosciences
Gizem Terzioglu, Tracy L. Young-Pearse
Summary: Recent genetic studies have highlighted the importance of microglia in Alzheimer's disease (AD), with AD-associated genes expressed in microglia being enriched in AD risk loci. SHIP1, encoded by the AD-associated gene INPP5D, has been identified as a key regulator of microglial phagocytosis and immune response. This study provides evidence for a connection between SHIP1 activity and NLRP3 inflammasome activation in AD, shedding light on the role of microglial signaling pathways in AD-related inflammation.
MOLECULAR NEURODEGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Dahlia Palevski, Gil Ben-David, Yehonatan Weinberger, Rabeei Haj Daood, Jose A. Fernandez, Ivan Budnik, Sarina Levy-Mendelovich, Gili Kenet, Yael Nisgav, Dov Weinberger, John H. Griffin, Tami Livnat
Summary: 3K3A-APC has been shown to have anti-inflammatory properties and may be a novel treatment for retinal diseases associated with inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jiping Li, Xinping Dai, Liuyi Zhou, Xinxiu Li, Dongxiao Pan
Summary: This study demonstrates that Edaravone (EDA) can improve neurobehavioral functions and alleviate neuroinflammation in a rat model of Parkinson's disease by inhibiting NLRP3 inflammasome activation and regulating microglia M1/M2 polarization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jiao Meng, Ting Ding, Yuhua Chen, Tianlin Long, Quanhua Xu, Wenqing Lian, Wei Liu
Summary: This study demonstrates that Meg3 regulates microglia inflammation by targeting the miR-7a-5p/Nlrp3 pathway. The findings suggest that the inflammatory response induced by Meg3 may be achieved through the regulation of miR-7a-5p expression and Nlrp3 protein expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Takumi Satoh, Dorit Trudler, Chang-Ki Oh, Stuart A. Lipton
Summary: This article reviews the potential applications of carnosic acid (CA) and carnosol (CS) in rosemary for conditions such as Alzheimer's disease, Parkinson's disease, and COVID-19. It highlights the antioxidant, anti-inflammatory, and neuroprotective effects of CA, as well as its potential to inhibit the NLRP3 inflammasome. The article suggests that CA-related compounds could serve as therapeutics for acute and chronic neurological effects caused by SARS-CoV-2 infection and other neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Review
Medicine, General & Internal
Zhigang Liang, Shaowan Yang, Xuwen Sun, Bing Li, Wei Li, Zhuli Liu, Guoping Yu
Article
Medicine, General & Internal
Zhigang Liang, Wei Li, Shaowan Yang, Zhuli Liu, Xuwen Sun, Xiaoyu Gao, Guoping Yu
Article
Geriatrics & Gerontology
Zhigang Liang, Zhuli Liu, Xuwen Sun, Manli Tao, Xiao Xiao, Guoping Yu, Xiaomin Wang
FRONTIERS IN AGING NEUROSCIENCE
(2019)
Article
Immunology
Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang
JOURNAL OF NEUROINFLAMMATION
(2020)
Review
Medicine, General & Internal
Junliang Zhang, Shuangfeng Huang, Luyao Xu, Manli Tao, Yujun Zhao, Zhigang Liang
Summary: Listeria monocytogenes infective encephalitis is a rare phenomenon, with brain abscess even rarer. Early accurate diagnosis and standardized treatment are crucial in promoting recovery and improving prognosis for this condition.
Article
Clinical Neurology
Shuya Li, Yuesong Pan, Ziran Wang, Zhigang Liang, Huisheng Chen, Dong Wang, Yi Sui, Xingquan Zhao, Yilong Wang, WanLiang Du, Huaguang Zheng, Yongjun Wang
Summary: This study compared the safety of different doses of rhTNK-tPA with standard rt-PA in Chinese AIS patients, showing that rhTNK-tPA administered within 3 hours of symptom onset was well tolerated at all doses. Further investigations are needed to establish the dose-efficacy profile of rhTNK-tPA.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Clinical Neurology
Zhigang Liang, Junliang Zhang, Shuangfeng Huang, Shaowan Yang, Luyao Xu, Wei Xiang, Manman Zhang
Summary: This study aimed to investigate the effectiveness and safety of infusing tirofiban after intravenous thrombolysis (IVT) in patients with acute non-cardiogenic ischemic stroke. The results showed that the combination of low-dose rt-PA and tirofiban did not increase the risk of intracranial hemorrhage and mortality, and it was associated with neurological improvement.
Review
Clinical Neurology
Shuangfeng Huang, Qianqian Huang, Zhongbao Zhou, Junliang Zhang, Yan Zhan, Zhigang Liang
Summary: The aim of this study was to evaluate the effect of Viola odorata extract on the treatment of insomnia. Through systematic review and meta-analysis, it was found that the Viola extract group showed significant improvement in total PSQI scores, subjective sleep quality score, sleep duration score, and ISI score compared to the placebo group. However, no significant differences were observed in sleep latency, habitual sleep efficiency, sleep disturbances, and daytime dysfunction between the two groups.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Wei Xiang, Hongchun Wei, Luyao Xu, Zhigang Liang
Summary: This article presents a rare case of orbital apex syndrome (OAS) secondary to apical periodontitis. The patient exhibited symptoms of orbital apex and cranial nerve injury, but the atypical early symptoms led to delayed diagnosis and treatment. The importance of early detection and suspicion of orbital apex-related complications is emphasized.
Review
Clinical Neurology
Wei Xiang, Zhigang Liang, Manman Zhang, Hongchun Wei, Zhongwen Sun, Yaodong Lv, Yuedan Meng, Wei Li, Huaguang Zheng, Hongxia Zhang
Summary: This meta-analysis reveals that the prominent veins sign (PVS) is associated with an unfavorable prognosis in patients with acute ischemic stroke (AIS) but does not increase the risk of hemorrhagic transformation. The correlation between PVS and unfavorable functional outcome is particularly evident in patients receiving recanalization therapy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Luyao Xu, Xiaodi Chen, Wei Xiang, Hongchun Wei, Zhigang Liang
Summary: The study found that cerebral vascular fenestration occurs most frequently in the basilar artery and may be combined with other vascular diseases. Fenestration in the posterior circulation may be related to cerebrovascular diseases. However, no clear clinical relevance was observed between fenestration and cerebral infarction, and no definite association was found between fenestration and aneurysm. For patients with cerebral infarctions related to fenestration, long-term antiplatelet and statin therapy may be safe and effective.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Luyao Xu, Hongchun Wei, Zhongwen Sun, Tongpeng Chu, Min Li, Ruhui Liu, Li Jiang, Zhigang Liang
Summary: This study investigates the dynamic alterations in spontaneous neural activity of the brain during the acute phase of post-stroke aphasia (PSA) using dynamic amplitude of low-frequency fluctuation (dALFF). The study finds greater variance of dALFF in the cerebellar network (CBN) and left fronto-temporo-parietal network (FTPN) in the PSA group. Moreover, it identifies two dALFF states among PSA patients, with a higher number of transitions between the states compared to healthy controls.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Wei Li, Hao Li, Chaoxia Lu, Jialu Zhao, Huichun Xu, Zhe Xu, Braxton Mitchell, Yong Jiang, Hong-Qiu Gu, Qin Xu, Anxin Wang, Xia Meng, Jinxi Lin, Jing Jing, Zixiao Li, Wanlin Zhu, Zhigang Liang, Mengxing Wang, Yongjun Wang
Summary: This study performed targeted next-generation sequencing on 10,428 adult ischaemic stroke/transient ischaemic attack patients and identified 792 individuals with potential risk for monogenic diseases. The most common monogenic cause of stroke was cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Late onset of stroke symptoms, the presence of common vascular risk factors, and the absence of a prominent family history may contribute to the underdiagnosis of monogenic stroke in adult patients.
STROKE AND VASCULAR NEUROLOGY
(2023)
Review
Medicine, Research & Experimental
Shuangfeng Huang, Junliang Zhang, Manli Tao, Yaodong Lv, Luyao Xu, Zhigang Liang
Summary: Chorea-acanthocytosis (ChAc) is a rare neurodegenerative disease with various early clinical manifestations, thought to be caused by VPS13A mutations. The final diagnosis of ChAc can be established by genetic analysis or protein expression via Western blotting. Supportive treatments and nursing play a crucial role in improving the quality of life for patients, while the impact of neuroimaging and neuropathological diagnosis in a larger group of ChAc should be further investigated in future studies.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Lin Sun, Zhen-Xing Wang, Guo-Ping Yu, Shao-Wan Yang, Zhi-Gang Liang
ACTA MEDICA MEDITERRANEA
(2019)