Article
Pharmacology & Pharmacy
Melissa S. O'Brien, Jason J. McDougall
Summary: The study compared the role of PAR4 in early and late stage osteoarthritis pain, and found that PAR4 may be a viable target for treating early onset OA pain or episodic inflammatory flares.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ali A. Aghdassi, Christine Pham, Lukas Zierke, Vincent Mariaule, Brice Korkmaz, Moez Rhimi
Summary: This review emphasizes the importance of CatC as a potential therapeutic target in inflammatory disorders.
Article
Chemistry, Applied
Ting Cao, Liang Zhang, Yun Liu, Hong Ma
Summary: This study developed the first near-infrared ratiometric fluorescence sensor (TMNF) for monitoring and imaging neutrophil elastase (NE) in vivo and in vitro. Cell imaging results showed that NE was highly expressed in cells treated with pro-inflammatory factors, and NE activity was significantly reduced after pretreatment with the enzyme inhibitor. Relevant experiments demonstrated that inflammation can lead to increased expression of NE in vivo. The imaging of the probe in inflammation mice demonstrated excellent practicality, making it an effective tool for the early diagnosis and treatment of diseases related to inflammatory lesions.
Article
Gastroenterology & Hepatology
Qin Tan, Xiao Ma, Bing Yang, Ye Liu, Yibin Xie, Xijun Wang, Wei Yuan, Jie Ma
Summary: This study reveals the pathogenic mechanism of the periodontal pathogen P. gingivalis in pancreatic cancer. The study found that P. gingivalis is present in both the oral cavity and tumor tissues of PC patients. When exposed to P. gingivalis, tumor development is accelerated and the cancerous pancreas exhibits a neutrophils-dominated inflammatory environment.
Article
Pharmacology & Pharmacy
Ganyu Wang, Weiqiang Jing, Yuxuan Bi, Yue Li, Liang Ma, Hui Yang, Yuankai Zhang
Summary: The study identified neutrophil elastase (NE) as a significant factor in osteoarthritis (OA), inducing chondrocyte apoptosis and facilitating OA development via the caspase signaling pathway. Inhibition of NE showed potential as a therapy for OA by mitigating chondrocyte apoptosis and pathological processes in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Magdalena K. Kaneva
Summary: Cartilage maintenance relies on the delicate balance between anabolism and catabolism. In osteoarthritis, cartilage breakdown, synovial inflammation, and bone changes lead to reduced joint mobility and pain, with neutrophil elastase activating MMP-13, causing cartilage destruction. Potential treatment strategies should focus on preventing the loss of alpha-1-antitrypsin to halt osteoarthritis progression.
Article
Biochemistry & Molecular Biology
David J. Wilkinson, Adrian M. D. Falconer, Helen L. Wright, Hua Lin, Kazuhiro Yamamoto, Kathleen Cheung, Sarah H. Charlton, Maria del Carmen Arques, Sabina Janciauskiene, Ramsay Refaie, Kenneth S. Rankin, David A. Young, Andrew D. Rowan
Summary: This study identifies elastase as a novel activator of pro-MMP-13, which has relevance for cartilage collagen destruction in OA patients with synovitis. Elastase induced significant collagen destruction from human OA cartilage ex vivo in an MMP-dependent manner, and activated pro-MMP-13 more potently than MMP-3. Additionally, active MMP-13 specifically inactivated the major elastase inhibitor AAT, further implicating elastase in cartilage breakdown in OA.
Article
Immunology
Emily Pickering, Elizabeth L. Steels, Kathryn J. Steadman, Amanda Rao, Luis Vitetta
Summary: This study demonstrated that a palmitoylethanolamide (PEA) formulation can reduce diabetic peripheral neuropathic pain and inflammation, while improving mood and sleep. Further research is needed to investigate the effectiveness of PEA as an adjunct medicine or monotherapy pain analgesic.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haizhu Xing, Shubo Zhang, Min You, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: In this study, the neuroprotective effects and mechanisms of thymoquinone (TQ) in paclitaxel-induced peripheral neuropathy (PIPN) were investigated. The results demonstrated that TQ significantly alleviated pain behavior, modulated pathological changes, and reduced inflammatory factors induced by PIPN. Further experiments revealed that TQ exerts neuroprotective effects by regulating the TLR4/MyD88 and its downstream NF-kappa B and MAPKs inflammatory pathways. Molecular docking and cellular thermal shift assay confirmed the interaction between TQ and TLR4.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Medicine, Research & Experimental
Allison D. Desforges, Chance M. Hebert, Allyson L. Spence, Bailey Reid, Hemangini A. Dhaibar, Diana Cruz-Topete, Elyse M. Cornett, Alan David Kaye, Ivan Urits, Omar Viswanath
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a complex condition that affects sensory functions. Currently, there are no approved preventive agents, but Duloxetine is an effective treatment. Developing prevention and treatment strategies for CIPN is crucial in improving patients' quality of life.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Thomas H. Craven, Tashfeen Walton, Ahsan R. Akram, Emma Scholefield, Neil McDonald, Adam D. L. Marshall, Duncan C. Humphries, Bethany Mills, Thane A. Campbell, Annya Bruce, Joanne Mair, James W. Dear, David E. Newby, Adam T. Hill, Timothy S. Walsh, Chris Haslett, Kevin Dhaliwal
Summary: The development of a molecular imaging probe targeting neutrophil activation allowed for real-time identification of neutrophil activity in the lungs of patients, enabling biological stratification based on disease states and severity. Evaluation of the probe's imaging responses in different patient populations confirmed that the optical signal was indeed due to the probe's function and neutrophil activation.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Joachim Hog Mortensen, Dovile Sinkeviciute, Tina Manon-Jensen, Viktor Domislovic, Kathryn McCall, Christian S. Thudium, Marko Brinar, Patrik Onnerfjord, Carl S. Goodyear, Zeljko Krznaric, Morten Asser Karsdal, Anne-Christine Bay-Jensen
Summary: The study developed a novel serum calprotectin enzyme-linked immunosorbent assay for monitoring disease activity in inflammatory bowel disease patients. This method showed strong correlations with endoscopic scores and disease severity.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Biochemistry & Molecular Biology
Ankita Tulangekar, Tamar E. Sztal
Summary: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the dystrophin gene. Lack of functional dystrophin protein leads to fragile muscle membranes and increased susceptibility to damage during contraction. Inflammation plays a crucial role in exacerbating muscle damage and impairing regeneration in DMD patients, with neutrophils releasing inflammatory compounds that prolong the inflammatory response.
Article
Biochemistry & Molecular Biology
Claudius Wagner, Anita Balazs, Jolanthe Schatterny, Zhe Zhou-Suckow, Julia Duerr, Carsten Schultz, Marcus A. Mall
Summary: Elevated levels of MMP-9 and NE are associated with bronchiectasis and lung function decline in CF patients. However, the role of MMP-9 in CF-like lung disease in mice is not significant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
James D. Chalmers, Abhya Gupta, Sanjay H. Chotirmall, April Armstrong, Peter Eickholz, Naoki Hasegawa, Pamela J. McShane, Anne E. O'Donnell, Michal Shteinberg, Henrik Watz, Anastasia Eleftheraki, Claudia Diefenbach, Wiebke Sauter
Summary: New therapies are needed to improve the conditions of bronchiectasis patients by reducing airway inflammation, improving symptoms, and preventing further damage. The design of a phase 2 trial assessing the efficacy and safety of a novel CatC inhibitor, BI 1291583, in adult patients with bronchiectasis is presented. The study includes a screening period, treatment period, and follow-up period, and will evaluate the dose-response relationship of BI 1291583 on time to first pulmonary exacerbation.
Article
Endocrinology & Metabolism
Eugene Krustev, Milind M. Muley, Jason J. McDougall
Review
Rheumatology
Kai Fu, Sarah R. Robbins, Jason J. McDougall
Article
Behavioral Sciences
L. D. Ellis, F. Berrue, M. Morash, J. C. Achenbach, J. Hill, J. J. McDougall
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Melissa O'Brien, Jason J. McDougall
CURRENT OPINION IN PHARMACOLOGY
(2018)
Article
Orthopedics
R. Pujol, C. A. Girard, H. Richard, I. Hassanpour, M. P. Binette, G. Beauchamp, J. J. McDougall, S. Laverty
OSTEOARTHRITIS AND CARTILAGE
(2018)
Article
Multidisciplinary Sciences
Ramin Goudarzi, Allison Reid, Jason J. McDougall
Article
Anesthesiology
Melissa S. O'Brien, Holly T. A. Philpott, Jason J. McDougall
Article
Multidisciplinary Sciences
Michael Mousseau, Nicole E. Burma, Kwan Yeop Lee, Heather Leduc-Pessah, Charlie H. T. Kwok, Allison R. Reid, Melissa O'Brien, Boriss Sagalajev, Jo Anne Stratton, Natalya Patrick, Patrick L. Stemkowski, Jeff Biernaskie, Gerald W. Zamponi, Paul Salos, Jason J. McDougall, Steven A. Prescott, John R. Matyas, Tuan Trang
Article
Cell Biology
Melissa S. O'Brien, Jason J. McDougall
MECHANISMS OF AGEING AND DEVELOPMENT
(2019)
Article
Cell Biology
Josiane C. S. Mapplebeck, Louis-Etienne Lorenzo, Kwan Yeop Lee, Cedric Gauthier, Milind M. Muley, Yves De Koninck, Steven A. Prescott, Michael W. Salter
Article
Biochemistry & Molecular Biology
Magdalena K. Kaneva, Milind M. Muley, Eugene Krustev, Allison R. Reid, Patricia R. Souza, Francesco Dell'Accio, Jason J. McDougall, Mauro Perretti
Summary: The study demonstrates that AAT possesses anti-inflammatory, analgesic, and chondroprotective properties, reversing joint inflammation and cartilage degradation, promoting the transcription of cartilage-related genes, enhancing chondrogenic differentiation, and acting through CREB signaling pathway and inhibition of Wnt/beta-catenin pathways.
Review
Biochemistry & Molecular Biology
Flora Lucena, Jason J. McDougall
Summary: Serine proteases play a dual role in arthritic joints by not only causing destruction but also signaling pain and inflammation. Protease activated receptors (PARs) have the potential to regulate joint homeostasis and targeting them may offer therapeutic benefits for alleviating pain and destructive nature of elevated proteases in arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Holly T. Philpott, Jason J. McDougall
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Rheumatology
Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid, Eugene Krustev
ARTHRITIS RESEARCH & THERAPY
(2017)