Microglial pannexin-1 channel activation is a spinal determinant of joint pain

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

(2017) Nicole E Burma et al.   NATURE MEDICINE

Probenecid directly impairs activation of the canine P2X7 receptor

(2017) Rachael Bartlett et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Hematopoietic pannexin 1 function is critical for neuropathic pain

(2017) Janelle L. Weaver et al.   Scientific Reports

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

(2016) Takahiro Masuda et al.   Nature Communications

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

(2016) Thomas Pitcher et al.   Jove-Journal of Visualized Experiments

Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis

(2015) W. Rahman et al.   NEUROSCIENCE

Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade

(2015) Kwan Yeop Lee et al.   PAIN

Calcitonin Gene-Related Peptide-Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen-Induced Arthritis

(2015) Francisco R. Nieto et al.   Arthritis & Rheumatology

A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments

(2014) Robert P Bonin et al.   Molecular Pain

Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord

(2014) David Bravo et al.   PAIN

Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

(2013) Erin Teeple et al.   AAPS Journal

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

(2013) Anindya Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

P2X7 receptor-Pannexin1 interaction mediates stress-induced interleukin-1 beta expression in human periodontal ligament cells

(2013) K. Kanjanamekanant et al.   JOURNAL OF PERIODONTAL RESEARCH

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases

(2012) N. L. Weilinger et al.   JOURNAL OF NEUROSCIENCE

Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice

(2012) J. Lampa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Contribution of Spinal Glial Cells to Chronic Pain Behaviour in the Monosodium Iodoacetate Model of Osteoarthritic Pain

(2011) Devi Rani Sagar et al.   Molecular Pain

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

(2010) Anna K. Clark et al.   GLIA

Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients

(2009) Stephen E. Gwilym et al.   ARTHRITIS AND RHEUMATISM

Technique for collection of cerebrospinal fluid from the cisterna magna in rat

(2009) Christina C. Pegg et al.   JOURNAL OF NEUROSCIENCE METHODS

Behavioural and Electrophysiological Characterisation of Experimentally Induced Osteoarthritis and Neuropathy in C57Bl/6 Mice

(2009) Victoria L Harvey et al.   Molecular Pain

Grading of monosodium iodoacetate-induced osteoarthritis reveals a concentration-dependent sensitization of nociceptors in the knee joint of the rat

(2009) Niklas Schuelert et al.   NEUROSCIENCE LETTERS

Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function

(2009) Luis Constandil et al.   ARTHRITIS RESEARCH & THERAPY

Probenecid, a gout remedy, inhibits pannexin 1 channels

(2008) William Silverman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Injury-Induced Changes in mRNA Levels Differ Widely between Anterior Cruciate Ligament and Medial Collateral Ligament

(2008) Jasmine A. Beye et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Spinal interleukin-1β in a mouse model of arthritis and joint pain

(2008) Paolo M. Fiorentino et al.   ARTHRITIS AND RHEUMATISM

Long-Term Actions of Interleukin-1β on Delay and Tonic Firing Neurons in Rat Superficial Dorsal Horn and Their Relevance to Central Sensitization

(2008) Sabrina L Gustafson-Vickers et al.   Molecular Pain