Glutamate, T cells and multiple sclerosis

CD4+HLA-G+ regulatory T cells: Molecular signature and pathophysiological relevance

(2016) Susann Pankratz et al.   HUMAN IMMUNOLOGY

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity

(2016) Dirk Luchtman et al.   JOURNAL OF NEUROCHEMISTRY

Regulatory T cell number in multiple sclerosis patients: A meta-analysis

(2016) Ali Noori-Zadeh et al.   Multiple Sclerosis and Related Disorders

Oral fingolimod reduces glutamate-mediated intracortical excitability in relapsing–remitting multiple sclerosis

(2015) D. Landi et al.   CLINICAL NEUROPHYSIOLOGY

Allosteric modulators of NMDA receptors: multiple sites and mechanisms

(2015) Shujia Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures

(2015) Angela Ruban et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity

(2015) Joshua M. Gammon et al.   JOURNAL OF CONTROLLED RELEASE

In vivo evidence of glutamate toxicity in multiple sclerosis

(2014) Christina J. Azevedo et al.   ANNALS OF NEUROLOGY

Il-1β Dependent Cerebellar Synaptopathy in a Mouse Mode of Multiple Sclerosis

(2014) Georgia Mandolesi et al.   CEREBELLUM

Neuroprotective Immunity: T Cell-Derived Glutamate Endows Astrocytes with a Neuroprotective Phenotype

(2014) S. K. Garg et al.   JOURNAL OF IMMUNOLOGY

Towards Neuroimmunotherapy for Cancer: the Neurotransmitters Glutamate, Dopamine and GnRH-II augment substantially the ability of T cells of few Head and Neck cancer patients to perform spontaneous migration, chemotactic migration and migration towards the autologous tumor, and also elevate markedly the expression of CD3zeta and CD3epsilon TCR-associated chains

(2014) Sven Saussez et al.   JOURNAL OF NEURAL TRANSMISSION

Glutamate and Vivian Teichberg: a story about science, medicine, memory and love

(2014) Mia Levite Teichberg et al.   JOURNAL OF NEURAL TRANSMISSION

The role of glutamate and its receptors in multiple sclerosis

(2014) Ivana R. Stojanovic et al.   JOURNAL OF NEURAL TRANSMISSION

Glutamate and its receptors in cancer

(2014) Andrzej Stepulak et al.   JOURNAL OF NEURAL TRANSMISSION

Brain to blood glutamate scavenging as a novel therapeutic modality: a review

(2014) Matthew Boyko et al.   JOURNAL OF NEURAL TRANSMISSION

The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells

(2014) Yonatan Ganor et al.   JOURNAL OF NEURAL TRANSMISSION

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice

(2014) Francesco Fazio et al.   NEUROPHARMACOLOGY

IL-17 and Glutamate Excitotoxicity in the Pathogenesis of Multiple Sclerosis

(2014) M. Kostic et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia

(2014) M Pérez-Mato et al.   Cell Death & Disease

Blood Glutamate Scavenging as a Novel Neuroprotective Treatment for Paraoxon Intoxication

(2013) Angela Ruban et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Glatiramer Acetate Protects Against Inflammatory Synaptopathy in Experimental Autoimmune Encephalomyelitis

(2013) Antonietta Gentile et al.   Journal of Neuroimmune Pharmacology

Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter

(2013) Nico Melzer et al.   Journal of Neuroinflammation

Modulation of Neurological Deficits and Expression of Glutamate Receptors during Experimental Autoimmune Encephalomyelitis after Treatment with Selected Antagonists of Glutamate Receptors

(2013) Grzegorz Sulkowski et al.   Biomed Research International

Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis

(2012) G Grasselli et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMPA receptors as drug targets in neurological disease - advantages, caveats, and future outlook

(2012) Philip K.-Y. Chang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Blood Glutamate Scavenging: Insight into Neuroprotection

(2012) Akiva Leibowitz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas

(2012) Angela Ruban et al.   INVESTIGATIONAL NEW DRUGS

Domain Architecture of a Calcium-Permeable AMPA Receptor in a Ligand-Free Conformation

(2012) Charles R. Midgett et al.   Frontiers in Molecular Neuroscience

Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation

(2011) Mark L Mayer   CURRENT OPINION IN NEUROBIOLOGY

GOT to rid the body of excess glutamate

(2011) Vivian I Teichberg   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glutamate signaling through the kainate receptor enhances human immunoglobulin production

(2011) Jamie L. Sturgill et al.   JOURNAL OF NEUROIMMUNOLOGY

Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells

(2010) P Affaticati et al.   CELL DEATH AND DIFFERENTIATION

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

(2010) Francesca Fallarino et al.   NATURE MEDICINE

Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats

(2010) Andrezza Sossai Rodrigues Carvalho et al.   NEUROCHEMISTRY INTERNATIONAL

Expression of glutamate receptor subunits in human cancers

(2009) Andrzej Stepulak et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Role of dopamine in the physiology of T-cells and dendritic cells

(2009) Rodrigo Pacheco et al.   JOURNAL OF NEUROIMMUNOLOGY

The Neuroprotective Effects of Oxaloacetate in Closed Head Injury in Rats is Mediated by its Blood Glutamate Scavenging Activity

(2009) Alexander Zlotnik et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Human T-leukemia and T-lymphoma express glutamate receptor AMPA GluR3, and the neurotransmitter glutamate elevates the cancer-related matrix-metalloproteinases inducer CD147/EMMPRIN, MMP-9 secretion and engraftment of T-leukemiain vivo

(2009) Yonatan Ganor et al.   LEUKEMIA & LYMPHOMA

N-Methyl-D-Aspartate and σ-Ligands Change the Production of Interleukins 8 and 10 in Lymphocytes through Modulation of the NMDA Glutamate Receptor

(2009) Eka Kvaratskhelia et al.   NEUROIMMUNOMODULATION

Memory and the NMDA Receptors

(2009) Fei Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glutamate levels and activity of the T cell voltage-gated potassium Kv1.3 channel in patients with systemic lupus erythematosus

(2008) C. Poulopoulou et al.   ARTHRITIS AND RHEUMATISM

Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis

(2008) Olatz Pampliega et al.   JOURNAL OF NEUROIMMUNOLOGY

Homeostasis of glutamate in brain fluids: An accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies

(2008) V.I. Teichberg et al.   NEUROSCIENCE

Glutamate Receptor Expression in Multiple Sclerosis Lesions

(2007) Jia Newcombe et al.   BRAIN PATHOLOGY

Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes

(2006) Annalisa Chiocchetti et al.   BRITISH JOURNAL OF PHARMACOLOGY