Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates

Studying Brain Circuit Function with Dynamic Causal Modeling for Optogenetic fMRI

(2017) David Bernal-Casas et al.   NEURON

Targeting Neural Circuits

(2016) Priyamvada Rajasethupathy et al.   CELL

Complementary Contributions of Striatal Projection Pathways to Action Initiation and Execution

(2016) Fatuel Tecuapetla et al.   CELL

Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques

(2016) William R. Stauffer et al.   CELL

An Emerging Technology Framework for the Neurobiology of Appetite

(2016) Scott M. Sternson et al.   Cell Metabolism

Strategies for targeting primate neural circuits with viral vectors

(2016) Yasmine El-Shamayleh et al.   JOURNAL OF NEUROPHYSIOLOGY

Npas1+ Pallidal Neurons Target Striatal Projection Neurons

(2016) K. E. Glajch et al.   JOURNAL OF NEUROSCIENCE

Effects of Optogenetic Activation of Corticothalamic Terminals in the Motor Thalamus of Awake Monkeys

(2016) A. Galvan et al.   JOURNAL OF NEUROSCIENCE

Rapid signalling in distinct dopaminergic axons during locomotion and reward

(2016) M. W. Howe et al.   NATURE

Biophysical constraints of optogenetic inhibition at presynaptic terminals

(2016) Mathias Mahn et al.   NATURE NEUROSCIENCE

A viral strategy for targeting and manipulating interneurons across vertebrate species

(2016) Jordane Dimidschstein et al.   NATURE NEUROSCIENCE

Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice

(2016) Teresa H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses

(2016) Hyun Joo Lee et al.   NEURON

Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex

(2016) Carsten Klein et al.   NEURON

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval

(2016) Anna Beyeler et al.   NEURON

Principles of Synaptic Organization of GABAergic Interneurons in the Striatum

(2016) Christoph Straub et al.   NEURON

A Large-Scale Interface for Optogenetic Stimulation and Recording in Nonhuman Primates

(2016) Azadeh Yazdan-Shahmorad et al.   NEURON

The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala

(2016) David S. Grayson et al.   NEURON

Rabies Virus CVS-N2c ΔG Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability

(2016) Thomas R. Reardon et al.   NEURON

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

FEF inactivation with improved optogenetic methods

(2016) Leah Acker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

(2016) Yuji Nagai et al.   Nature Communications

Optogenetic approaches addressing extracellular modulation of neural excitability

(2016) Emily A. Ferenczi et al.   Scientific Reports

Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons

(2016) Arpiar Saunders et al.   PLoS One

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

(2015) Xin Chen et al.   ACS Chemical Neuroscience

Decoding Neural Circuits that Control Compulsive Sucrose Seeking

(2015) Edward H. Nieh et al.   CELL

Shaping action sequences in basal ganglia circuits

(2015) Xin Jin et al.   CURRENT OPINION IN NEUROBIOLOGY

CAV-2—why a canine virus is a neurobiologist's best friend

(2015) Felix Junyent et al.   CURRENT OPINION IN PHARMACOLOGY

Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex

(2015) Yao Lu et al.   JOURNAL OF NEUROPHYSIOLOGY

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

(2015) Wenjie Ren et al.   NATURE NEUROSCIENCE

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

(2015) Mark A G Eldridge et al.   NATURE NEUROSCIENCE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Heterosynaptic Regulation of External Globus Pallidus Inputs to the Subthalamic Nucleus by the Motor Cortex

(2015) Hong-Yuan Chu et al.   NEURON

Antagonistic but Not Symmetric Regulation of Primary Motor Cortex by Basal Ganglia Direct and Indirect Pathways

(2015) Ian A. Oldenburg et al.   NEURON

Optogenetic Activation of Normalization in Alert Macaque Visual Cortex

(2015) Jonathan J. Nassi et al.   NEURON

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

(2015) Daniel J Urban et al.   NEUROPSYCHOPHARMACOLOGY

Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex

(2015) Akiya Watakabe et al.   NEUROSCIENCE RESEARCH

Mechanism of Deep Brain Stimulation

(2015) Satomi Chiken et al.   NEUROSCIENTIST

Optogenetic and pharmacological suppression of spatial clusters of face neurons reveal their causal role in face gender discrimination

(2015) Arash Afraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

(2015) E. A. Ferenczi et al.   SCIENCE

Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system

(2015) Ken-ichi Inoue et al.   Nature Communications

Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals

(2015) Heinrich S. Gompf et al.   Frontiers in Behavioral Neuroscience

Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms

(2015) Louise C. Parr-Brownlie et al.   Frontiers in Molecular Neuroscience

Modified toolbox for optogenetics in the nonhuman primate

(2015) Ji Dai et al.   Neurophotonics

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex

(2015) Annelies Gerits et al.   Neurophotonics

Double Virus Vector Infection to the Prefrontal Network of the Macaque Brain

(2015) Mineki Oguchi et al.   PLoS One

Chemogenetic Tools to Interrogate Brain Functions

(2014) Scott M. Sternson et al.   Annual Review of Neuroscience

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates

(2014) M A Kotterman et al.   GENE THERAPY

Injection parameters and virus dependent choice of promoters to improve neuron targeting in the nonhuman primate brain

(2014) W Lerchner et al.   GENE THERAPY

Distribution and morphological characteristics of striatal interneurons expressing calretinin in mice: A comparison with human and nonhuman primates

(2014) Sarah Petryszyn et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Achieving High-Frequency Optical Control of Synaptic Transmission

(2014) S. L. Jackman et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Assessment of Horizontal Interactions in Primary Visual Cortex

(2014) X. Huang et al.   JOURNAL OF NEUROSCIENCE

Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents

(2014) C. Straub et al.   JOURNAL OF NEUROSCIENCE

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

(2014) Xin Jin et al.   NATURE NEUROSCIENCE

SPECT-imaging of activity-dependent changes in regional cerebral blood flow induced by electrical and optogenetic self-stimulation in mice

(2014) Angela Kolodziej et al.   NEUROIMAGE

Detection of Optogenetic Stimulation in Somatosensory Cortex by Non-Human Primates - Towards Artificial Tactile Sensation

(2014) Travis May et al.   PLoS One

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

(2014) Tim Fieblinger et al.   Nature Communications

Balanced activity in basal ganglia projection pathways is critical for contraversive movements

(2014) Fatuel Tecuapetla et al.   Nature Communications

Biology of adeno-associated viral vectors in the central nervous system

(2014) Giridhar Murlidharan et al.   Frontiers in Molecular Neuroscience

Targeted CNS delivery using human MiniPromoters and demonstrated compatibility with adeno-associated viral vectors

(2014) Charles N de Leeuw et al.   Molecular Therapy-Methods & Clinical Development

Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

(2013) Ji Dai et al.   CURRENT BIOLOGY

Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain

(2013) W San Sebastian et al.   GENE THERAPY

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

(2013) S J Gray et al.   GENE THERAPY

Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primates

(2013) Lluis Samaranch et al.   HUMAN GENE THERAPY

Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks

(2013) Michael Michaelides et al.   JOURNAL OF CLINICAL INVESTIGATION

Optogenetics through windows on the brain in the nonhuman primate

(2013) Octavio Ruiz et al.   JOURNAL OF NEUROPHYSIOLOGY

Mapping Brain Metabolic Connectivity in Awake Rats with  PET and Optogenetic Stimulation

(2013) P. K. Thanos et al.   JOURNAL OF NEUROSCIENCE

Control of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons

(2013) B. S. Freeze et al.   JOURNAL OF NEUROSCIENCE

Saccade Modulation by Optical and Electrical Stimulation in the Macaque Frontal Eye Field

(2013) S. Ohayon et al.   JOURNAL OF NEUROSCIENCE

A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates

(2013) Ilker Ozden et al.   JOURNAL OF NEUROSCIENCE METHODS

The evolutionary origin of the vertebrate basal ganglia and its role in action selection

(2013) Sten Grillner et al.   JOURNAL OF PHYSIOLOGY-LONDON

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

(2013) Lluis Samaranch et al.   MOLECULAR THERAPY

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

Distinct extended amygdala circuits for divergent motivational states

(2013) Joshua H. Jennings et al.   NATURE

Corticostriatal and mesocortical dopamine systems: do species differences matter?

(2013) Yoland Smith et al.   NATURE REVIEWS NEUROSCIENCE

Probing and Regulating Dysfunctional Circuits Using Deep Brain Stimulation

(2013) Andres M. Lozano et al.   NEURON

Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity

(2013) S.-J. Zhang et al.   SCIENCE

Optogenetics in primates: a shining future?

(2013) Annelies Gerits et al.   TRENDS IN GENETICS

Revealing the secrets of neuronal circuits with recombinant rabies virus technology

(2013) Melanie Ginger et al.   Frontiers in Neural Circuits

Pharmacosynthetics: Reimagining the pharmacogenetic approach

(2012) Martilias S. Farrell et al.   BRAIN RESEARCH

Optogenetic identification of striatal projection neuron subtypes during in vivo recordings

(2012) Alexxai V. Kravitz et al.   BRAIN RESEARCH

Optogenetically Induced Behavioral and Functional Network Changes in Primates

(2012) Annelies Gerits et al.   CURRENT BIOLOGY

A glass-coated tungsten microelectrode enclosing optical fibers for optogenetic exploration in primate deep brain structures

(2012) Keita Tamura et al.   JOURNAL OF NEUROSCIENCE METHODS

Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease

(2012) Cristina Miguelez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

(2012) Jeremiah Y. Cohen et al.   NATURE

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA

(2012) Nicolas X. Tritsch et al.   NATURE

Distinct roles for direct and indirect pathway striatal neurons in reinforcement

(2012) Alexxai V Kravitz et al.   NATURE NEUROSCIENCE

Saccadic eye movements evoked by optogenetic activation of primate V1

(2012) Mehrdad Jazayeri et al.   NATURE NEUROSCIENCE

fMRI response to blue light delivery in the naïve brain: Implications for combined optogenetic fMRI studies

(2012) Isabel N. Christie et al.   NEUROIMAGE

Therapeutic Deep Brain Stimulation in Parkinsonian Rats Directly Influences Motor Cortex

(2012) Qian Li et al.   NEURON

Optogenetic Inactivation Modifies Monkey Visuomotor Behavior

(2012) James Cavanaugh et al.   NEURON

Cerebral blood volume MRI with intravascular superparamagnetic iron oxide nanoparticles

(2012) Seong-Gi Kim et al.   NMR IN BIOMEDICINE

Globus Pallidus External Segment Neuron Classification in Freely Moving Rats: A Comparison to Primates

(2012) Liora Benhamou et al.   PLoS One

In Vivo Optogenetic Control of Striatal and Thalamic Neurons in Non-Human Primates

(2012) Adriana Galvan et al.   PLoS One

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Neuron-Specific Gene Transfer Through Retrograde Transport of Lentiviral Vector Pseudotyped with a Novel Type of Fusion Envelope Glycoprotein

(2011) Shigeki Kato et al.   HUMAN GENE THERAPY

Distribution Properties of Lentiviral Vectors Administered into the Striatum by Convection-Enhanced Delivery

(2011) Edward White et al.   HUMAN GENE THERAPY

Selective Neural Pathway Targeting Reveals Key Roles of Thalamostriatal Projection in the Control of Visual Discrimination

(2011) S. Kato et al.   JOURNAL OF NEUROSCIENCE

The optogenetic (r)evolution

(2011) Martin L. Rein et al.   MOLECULAR GENETICS AND GENOMICS

Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric Disorders

(2011) Adam K Bevan et al.   MOLECULAR THERAPY

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

An optogenetic toolbox designed for primates

(2011) Ilka Diester et al.   NATURE NEUROSCIENCE

Analysis of a simulation algorithm for direct brain drug delivery

(2011) Kathryn Hammond Rosenbluth et al.   NEUROIMAGE

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9

(2011) Y. Masamizu et al.   NEUROSCIENCE

Deep Brain Stimulation for Parkinson Disease

(2010) Jeff M. Bronstein et al.   ARCHIVES OF NEUROLOGY

A Lentiviral Strategy for Highly Efficient Retrograde Gene Transfer by Pseudotyping with Fusion Envelope Glycoprotein

(2010) Shigeki Kato et al.   HUMAN GENE THERAPY

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

A regulatory toolbox of MiniPromoters to drive selective expression in the brain

(2010) E. Portales-Casamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months

(2009) L Alvarez et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

(2009) Hemraj B Dodiya et al.   MOLECULAR THERAPY

Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain

(2009) Eleni A Markakis et al.   MOLECULAR THERAPY

The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques

(2009) Lili Wang et al.   MOLECULAR THERAPY

The cell biology of rabies virus: using stealth to reach the brain

(2009) Matthias J. Schnell et al.   NATURE REVIEWS MICROBIOLOGY

Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain

(2009) Xue Han et al.   NEURON

Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors

(2009) J.L. Nathanson et al.   NEUROSCIENCE

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Dopamine Innervation in the Thalamus: Monkey versus Rat

(2008) M. A. Garcia-Cabezas et al.   CEREBRAL CORTEX

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

(2008) Massimo S. Fiandaca et al.   NEUROIMAGE