Optogenetics: 10 years of microbial opsins in neuroscience

A Synthetic Erectile Optogenetic Stimulator Enabling Blue-Light-Inducible Penile Erection

(2015) Taeuk Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors

(2015) Joshua H. Jennings et al.   CELL

Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex

(2015) Yao Lu et al.   JOURNAL OF NEUROPHYSIOLOGY

Thirst driving and suppressing signals encoded by distinct neural populations in the brain

(2015) Yuki Oka et al.   NATURE

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model

(2015) Julius A Steinbeck et al.   NATURE BIOTECHNOLOGY

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior

(2015) Jeff R Jones et al.   NATURE NEUROSCIENCE

Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics

(2015) György Buzsáki et al.   NEURON

Collateral Pathways from the Ventromedial Hypothalamus Mediate Defensive Behaviors

(2015) Li Wang et al.   NEURON

Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule Cells

(2015) Silvio G. Temprana et al.   NEURON

Photosensitivity of Neurons Enabled by Cell-Targeted Gold Nanoparticles

(2015) João L. Carvalho-de-Souza et al.   NEURON

Closed-Loop and Activity-Guided Optogenetic Control

(2015) Logan Grosenick et al.   NEURON

Spatiotemporal Control of Opioid Signaling and Behavior

(2015) Edward R. Siuda et al.   NEURON

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations

(2015) Tae Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of a light-gated potassium channel

(2015) C. Cosentino et al.   SCIENCE

Expanding the optogenetics toolkit

(2015) A. Berndt et al.   SCIENCE

Wireless magnetothermal deep brain stimulation

(2015) R. Chen et al.   SCIENCE

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

(2015) M. Creed et al.   SCIENCE

Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics

(2015) E. G. Govorunova et al.   SCIENCE

Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum

(2015) Yu-Wei Wu et al.   Cell Reports

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool

(2015) Michiel van Wyk et al.   PLOS BIOLOGY

Ventromedial hypothalamic neurons control a defensive emotion state

(2015) Prabhat S Kunwar et al.   eLife

State-Dependent Architecture of Thalamic Reticular Subnetworks

(2014) Michael M. Halassa et al.   CELL

Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit

(2014) Todd E. Anthony et al.   CELL

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Type II Cadherins Guide Assembly of a Direction-Selective Retinal Circuit

(2014) Xin Duan et al.   CELL

Optogenetic Mapping after Stroke Reveals Network-Wide Scaling of Functional Connections and Heterogeneous Recovery of the Peri-Infarct

(2014) Diana H. Lim et al.   JOURNAL OF NEUROSCIENCE

Skilled reaching relies on a V2a propriospinal internal copy circuit

(2014) Eiman Azim et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Circuit dynamics of adaptive and maladaptive behaviour

(2014) Karl Deisseroth   NATURE

Amygdala interneuron subtypes control fear learning through disinhibition

(2014) Steffen B. E. Wolff et al.   NATURE

Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus

(2014) Hyosang Lee et al.   NATURE

Bidirectional switch of the valence associated with a hippocampal contextual memory engram

(2014) Roger L. Redondo et al.   NATURE

Mechanosensory interactions drive collective behaviour in Drosophila

(2014) Pavan Ramdya et al.   NATURE

Galanin neurons in the medial preoptic area govern parental behaviour

(2014) Zheng Wu et al.   NATURE

Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice

(2014) Shrivats Mohan Iyer et al.   NATURE BIOTECHNOLOGY

Simultaneous all-optical manipulation and recording of neural circuit activity with cellular resolution in vivo

(2014) Adam M Packer et al.   NATURE METHODS

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

A comprehensive thalamocortical projection map at the mesoscopic level

(2014) Barbara J Hunnicutt et al.   NATURE NEUROSCIENCE

Short latency cerebellar modulation of the basal ganglia

(2014) Christopher H Chen et al.   NATURE NEUROSCIENCE

Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli

(2014) Joshua H Siegle et al.   NATURE NEUROSCIENCE

Reversal of theta rhythm flow through intact hippocampal circuits

(2014) Jesse Jackson et al.   NATURE NEUROSCIENCE

Parvalbumin interneurons provide grid cell–driven recurrent inhibition in the medial entorhinal cortex

(2014) Christina Buetfering et al.   NATURE NEUROSCIENCE

The GABAergic parafacial zone is a medullary slow wave sleep–promoting center

(2014) Christelle Anaclet et al.   NATURE NEUROSCIENCE

Cocaine exposure reorganizes cell type– and input-specific connectivity in the nucleus accumbens

(2014) Andrew F MacAskill et al.   NATURE NEUROSCIENCE

Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements

(2014) Rémi D Proville et al.   NATURE NEUROSCIENCE

Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields

(2014) John Peter Rickgauer et al.   NATURE NEUROSCIENCE

Orbitofrontal activation restores insight lost after cocaine use

(2014) Federica Lucantonio et al.   NATURE NEUROSCIENCE

Synapse-Specific Control of Experience-Dependent Plasticity by Presynaptic NMDA Receptors

(2014) Rylan S. Larsen et al.   NEURON

Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons

(2014) Verena Senn et al.   NEURON

Visual Cortex Modulates the Magnitude but Not the Selectivity of Looming-Evoked Responses in the Superior Colliculus of Awake Mice

(2014) Xinyu Zhao et al.   NEURON

Identification of a Brainstem Circuit Regulating Visual Cortical State in Parallel with Locomotion

(2014) A. Moses Lee et al.   NEURON

Descending Control of Swim Posture by a Midbrain Nucleus in Zebrafish

(2014) Tod R. Thiele et al.   NEURON

Balanced Interhemispheric Cortical Activity Is Required for Correct Targeting of the Corpus Callosum

(2014) Rodrigo Suárez et al.   NEURON

Ongoing Network State Controls the Length of Sleep Spindles via Inhibitory Activity

(2014) Péter Barthó et al.   NEURON

Restoring Visual Function to Blind Mice with a Photoswitch that Exploits Electrophysiological Remodeling of Retinal Ganglion Cells

(2014) Ivan Tochitsky et al.   NEURON

The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger

(2014) Ryunosuke Amo et al.   NEURON

Direct Reactivation of a Coherent Neocortical Memory of Context

(2014) Kiriana K. Cowansage et al.   NEURON

Pyramidal Cell-Interneuron Interactions Underlie Hippocampal Ripple Oscillations

(2014) Eran Stark et al.   NEURON

Optogenetic neuronal stimulation promotes functional recovery after stroke

(2014) M. Y. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

(2014) A. Berndt et al.   SCIENCE

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Conversion of Channelrhodopsin into a Light-Gated Chloride Channel

(2014) J. Wietek et al.   SCIENCE

Serotonergic versus Nonserotonergic Dorsal Raphe Projection Neurons: Differential Participation in Reward Circuitry

(2014) Ross A. McDevitt et al.   Cell Reports

Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus

(2014) Joshua H Siegle et al.   eLife

Serotonin and the Neuropeptide PDF Initiate and Extend Opposing Behavioral States in C. elegans

(2013) Steven W. Flavell et al.   CELL

Design and functional evaluation of an optically active μ-opioid receptor

(2013) Philip A. Barish et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mapping Brain Metabolic Connectivity in Awake Rats with  PET and Optogenetic Stimulation

(2013) P. K. Thanos et al.   JOURNAL OF NEUROSCIENCE

Multiple Sources of Striatal Inhibition Are Differentially Affected in Huntington's Disease Mouse Models

(2013) C. Cepeda et al.   JOURNAL OF NEUROSCIENCE

Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination

(2013) Petr Znamenskiy et al.   NATURE

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

(2013) Billy T. Chen et al.   NATURE

Distinct behavioural and network correlates of two interneuron types in prefrontal cortex

(2013) D. Kvitsiani et al.   NATURE

Distinct extended amygdala circuits for divergent motivational states

(2013) Joshua H. Jennings et al.   NATURE

Cortical interneurons that specialize in disinhibitory control

(2013) Hyun-Jae Pi et al.   NATURE

Optical control of mammalian endogenous transcription and epigenetic states

(2013) Silvana Konermann et al.   NATURE

Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex

(2013) Riccardo Beltramo et al.   NATURE NEUROSCIENCE

Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons

(2013) Carsten K Pfeffer et al.   NATURE NEUROSCIENCE

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

(2013) Sonia Jego et al.   NATURE NEUROSCIENCE

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Tuned thalamic excitation is amplified by visual cortical circuits

(2013) Anthony D Lien et al.   NATURE NEUROSCIENCE

A causal link between prediction errors, dopamine neurons and learning

(2013) Elizabeth E Steinberg et al.   NATURE NEUROSCIENCE

Convergent cortical innervation of striatal projection neurons

(2013) Geraldine J Kress et al.   NATURE NEUROSCIENCE

Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits

(2013) Keigo Kohara et al.   NATURE NEUROSCIENCE

Neural coding during active somatosensation revealed using illusory touch

(2013) Daniel H O'Connor et al.   NATURE NEUROSCIENCE

Odor Discrimination Requires Proper Olfactory Fast Oscillations in Awake Mice

(2013) Gabriel Lepousez et al.   NEURON

A Cortico-Hippocampal Learning Rule Shapes Inhibitory Microcircuit Activity to Enhance Hippocampal Information Flow

(2013) Jayeeta Basu et al.   NEURON

Feedback Inhibition Enables Theta-Nested Gamma Oscillations and Grid Firing Fields

(2013) Hugh Pastoll et al.   NEURON

BLA to vHPC Inputs Modulate Anxiety-Related Behaviors

(2013) Ada C. Felix-Ortiz et al.   NEURON

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

A Neural Circuit for Memory Specificity and Generalization

(2013) W. Xu et al.   SCIENCE

Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity

(2013) S.-J. Zhang et al.   SCIENCE

Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

(2013) E. Burguiere et al.   SCIENCE

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

(2013) S. E. Ahmari et al.   SCIENCE

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Genetically Engineered Fluorescent Voltage Reporters

(2012) Hiroki Mutoh et al.   ACS Chemical Neuroscience

GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

(2012) Dong Kong et al.   CELL

Wnt Signaling Regulates Acetylcholine Receptor Translocation and Synaptic Plasticity in the Adult Nervous System

(2012) Michael Jensen et al.   CELL

Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations

(2012) Marco Ledri et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Activation of specific interneurons improves V1 feature selectivity and visual perception

(2012) Seung-Hee Lee et al.   NATURE

Crystal structure of the channelrhodopsin light-gated cation channel

(2012) Hideaki E. Kato et al.   NATURE

Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning

(2012) Matthew T. C. Brown et al.   NATURE

Monkeys

(2012) Ken Liu   NATURE

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

(2012) Jeremiah Y. Cohen et al.   NATURE

Two-photon optogenetics of dendritic spines and neural circuits

(2012) Adam M Packer et al.   NATURE METHODS

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

(2012) Rohit Prakash et al.   NATURE METHODS

Motor circuits are required to encode a sensory model for imitative learning

(2012) Todd F Roberts et al.   NATURE NEUROSCIENCE

Thalamic control of cortical states

(2012) James F A Poulet et al.   NATURE NEUROSCIENCE

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

(2012) Jeanne T Paz et al.   NATURE NEUROSCIENCE

Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex

(2012) Luc J Gentet et al.   NATURE NEUROSCIENCE

Functional Properties of Cortical Feedback Projections to the Olfactory Bulb

(2012) Foivos Markopoulos et al.   NEURON

Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex

(2012) S. Melzer et al.   SCIENCE

Dynamics of Retrieval Strategies for Remote Memories

(2011) Inbal Goshen et al.   CELL

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

The Microbial Opsin Family of Optogenetic Tools

(2011) Feng Zhang et al.   CELL

Driving Opposing Behaviors with Ensembles of Piriform Neurons

(2011) Gloria B. Choi et al.   CELL

Phox2b-Expressing Neurons of the Parafacial Region Regulate Breathing Rate, Inspiration, and Expiration in Conscious Rats

(2011) S. B. G. Abbott et al.   JOURNAL OF NEUROSCIENCE

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

(2011) Garret D. Stuber et al.   NATURE

Functional identification of an aggression locus in the mouse hypothalamus

(2011) Dayu Lin et al.   NATURE

Perception of sniff phase in mouse olfaction

(2011) Matthew Smear et al.   NATURE

A disinhibitory microcircuit for associative fear learning in the auditory cortex

(2011) Johannes J. Letzkus et al.   NATURE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Leptin regulates the reward value of nutrient

(2011) Ana I Domingos et al.   NATURE NEUROSCIENCE

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement

(2011) Ilana B. Witten et al.   NEURON

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil BacteriumBeggiatoa

(2010) Manuela Stierl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substitution of 5-HT1AReceptor Signaling by a Light-activated G Protein-coupled Receptor

(2010) Eugene Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

Genetic dissection of an amygdala microcircuit that gates conditioned fear

(2010) Wulf Haubensak et al.   NATURE

Encoding of conditioned fear in central amygdala inhibitory circuits

(2010) Stephane Ciocchi et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion

(2010) Martin Hägglund et al.   NATURE NEUROSCIENCE

Degeneration keeps axons on the straight and narrow

(2010) Bruce D Carter   NATURE NEUROSCIENCE

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning

(2010) Joshua P. Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

(2010) I. B. Witten et al.   SCIENCE

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Structural Guidance of the Photocycle of Channelrhodopsin-2 by an Interhelical Hydrogen Bond

(2009) Christian Bamann et al.   BIOCHEMISTRY

Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics

(2009) John Y. Lin et al.   BIOPHYSICAL JOURNAL

Regionalized Loss of Parvalbumin Interneurons in the Cerebral Cortex of Mice with Deficits in GFR 1 Signaling

(2009) A. J. Canty et al.   JOURNAL OF NEUROSCIENCE

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

Escape Behavior Elicited by Single, Channelrhodopsin-2-Evoked Spikes in Zebrafish Somatosensory Neurons

(2008) Adam D. Douglass et al.   CURRENT BIOLOGY

Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins fromChlamydomonas

(2008) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice

(2007) Daniel Huber et al.   NATURE