Review
Chemistry, Inorganic & Nuclear
Chunyan Jia, Glen B. Deacon, Yingjie Zhang, Chuanzhu Gao
Summary: This article summarizes the main problems of platinum-based anticancer drugs, introduces Pt-IV drugs and their characteristics, and focuses on the combination therapy with nanocarriers, looking forward to the application prospects of Pt-IV drugs and nanotechnology in the field of cancer chemotherapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Qi-Rui Li, Hua-Zhen Xu, Rong-Cheng Xiao, Yan Liu, Jun-Ming Tang, Jian Li, Ting-Ting Yu, Bin Liu, Liu-Gen Li, Mei-Fang Wang, Ning Han, Yong-Hong Xu, Chao Wang, Naoki Komatsu, Li Zhao, Xing-Chun Peng, Tong-Fei Li, Xiao Chen
Summary: This study demonstrates the concept of tumor-targeted drug delivery mediated by platelets. Platelets loaded with doxorubicin attached to nanodiamonds can efficiently and effectively deliver the drug to tumor cells, resulting in inhibition of cell proliferation and apoptosis. Platelets also exhibit prolonged blood circulation time and excellent tumor distribution, making them promising carriers for nano-drug delivery to tumors.
Article
Pharmacology & Pharmacy
Tugce Boztepe, Sebastian Scioli-Montoto, Rocio C. Gambaro, Maria Esperanza Ruiz, Silvia Cabrera, Jose Aleman, German A. Islan, Guillermo R. Castro, Ignacio E. Leon
Summary: Colorectal cancer, the second leading cause of cancer death, is referred to as colon or rectal cancer depending on the site of formation. The platinum-based compound 8-QO-Pt has shown promising anticancer activity. In this study, three different systems of 8-QO-Pt-encapsulated nanostructured lipid carriers (NLCs) with riboflavin (RFV) were investigated. The results demonstrated the higher cytotoxicity of the 8-QO-Pt-loaded NLC/RFV formulations compared to free 8-QO-Pt, indicating the potential of RFV-targeted NLC systems for colon cancer treatment.
Article
Nanoscience & Nanotechnology
Dayoung Lee, Seungki Baek, Young-Youb Kim, Yongbin Bang, Han Na Jung, Hyung-Jun Im, Yoon-Kyu Song
Summary: In this study, hybrid nanospheres composed of DNA and proteins were developed for cancer targeting. The nanospheres showed excellent biocompatibility, high drug payload capacity, and in vivo imaging ability. The feasibility of cancer targeting and drug-loading capacity were tested, and the nanospheres were proven to have selective internalization in cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Oncology
Jia Xiang, Rui Zhao, Bo Wang, Xinran Sun, Xu Guo, Songwen Tan, Wenjie Liu
Summary: Nanotechnology plays an important role in the research of anti-tumor drugs, providing a way to improve drug efficacy and bioavailability by selecting appropriate nanocarriers.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
J. Zajda, A. Wroblewska, L. Ruzik, M. Matczuk
Summary: Conventional platinum-based anticancer therapies face challenges in drug distribution and severe side effects, highlighting the need for targeted delivery systems. Utilizing nanomaterials to develop Pt-based drug targeted delivery systems offers enhanced and selective delivery to cancer cells, paving the way for safer and more effective treatments. Experimental techniques and analytical methodologies are crucial for the characterization and development of novel therapies utilizing Pt-based DTDSs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Nanoscience & Nanotechnology
Hossein Zare, Sepideh Ahmadi, Amir Ghasemi, Mohammad Ghanbari, Navid Rabiee, Mojtaba Bagherzadeh, Mahdi Karimi, Thomas J. Webster, Michael R. Hamblin, Ebrahim Mostafavi
Summary: Carbon nanotubes have unique properties that make them suitable for drug and gene delivery, as well as applications in cancer therapy, anti-inflammatory treatments, and phototherapy. However, concerns about nanotoxicity and environmental impact remain, despite decades of research and potential benefits.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Joanna Kurczewska
Summary: This review focuses on the progress in chitosan-based nanoparticles for targeted delivery of antitumor drugs. It discusses literature reports from the past three years on the use of chitosan nanoparticles as carriers for active substances in antitumor therapy and potential new drugs with anticancer properties. Special attention is given to different treatments applied to enhance therapeutic effectiveness and minimize side effects of specific active substances.
Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Mo Li, Qiushi Guo, Chongli Zhong, Ziyan Zhang
Summary: Nanotechnology has revolutionized disease detection, prevention, management, and treatment. Cell membrane-based nanocarriers, as biomimetic nanoparticles, have unique advantages and applications. This comprehensive review highlights recent breakthroughs in biomimetic nanomaterials in cancer treatment, cardiovascular therapy, viral infections, COVID-19 management, and autoimmune diseases, and explores the synthesis processes.
Review
Chemistry, Multidisciplinary
Jiaxin Hu, Yanfei Liu, Yimin Du, Xingxing Peng, Zhenbao Liu
Summary: Organelles have been developed as drug carriers, offering advantages in drug loading efficiency and therapeutic effect enhancement. This review summarizes the biogenesis, isolation, and drug-loading methods of four types of organelles, and highlights their potential as drug-delivery systems for disease treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
S. Moraes, A. Marinho, S. Lima, A. Granja, J. P. Araujo, S. Reis, C. T. Sousa, C. Nunes
Summary: This study developed folic acid conjugated nanostructured lipid carriers (NLCs) as an effective doxorubicin delivery method targeted to breast cancer cells, with enhanced cellular uptake and targeting potential. In vitro studies showed good release performance and storage stability of the NLCs, indicating the potential for oral administration and targeted doxorubicin delivery to breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Kurzatkowska, Manuel A. Pazos, Jason I. Herschkowitz, Maria Hepel
Summary: The interactions of chemotherapeutic drugs with nanocage protein apoferritin are crucial for effective encapsulation and release of highly toxic drugs in controlled drug delivery systems. Different anthracycline drugs showed varying encapsulation efficiency and in vitro activity based on their lipophilicity. A model for molecular interactions between anthracyclines and APO nanocarriers was developed to compare with experimental results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Erik De Luca, Yang Wang, Igor Baars, Federica De Castro, Marco Lolaico, Danilo Migoni, Cosimo Ducani, Michele Benedetti, Bjorn Hogberg, Francesco Paolo Fanizzi
Summary: The DNA origami method has revolutionized the field of DNA nanotechnology, offering potential as a promising vehicle for therapeutic delivery. This study explores the use of wireframe DNA origami as carriers of platinum compounds in cancer therapy, focusing on cisplatin and phenanthriplatin as model compounds. The findings demonstrate the effectiveness of the ball-like origami nanostructure loaded with phenanthriplatin in reducing cell viability in a specific cancer cell line. These results provide valuable insights into the potential of wireframe DNA origami as a highly stable carrier for long time-release purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Zhongjian Pu, Yujia Wei, Yuanpeng Sun, Yajun Wang, Shilin Zhu
Summary: This review discusses the use of carbon nanotubes as drug carriers in non-small cell lung cancer therapy, as well as the impact of factors such as functionalization and drug loading on their toxicity and therapeutic effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
