Article
Pharmacology & Pharmacy
Artem O. O. Surov, Anna G. G. Ramazanova, Alexander P. P. Voronin, Ksenia V. V. Drozd, Andrei V. V. Churakov, German L. L. Perlovich
Summary: The study successfully extended the existing set of carbamazepine (CBZ) cocrystals by combining the drug with the positional isomers of acetamidobenzoic acid. The structural and energetic features of the CBZ cocrystals were analyzed, and three different virtual screening methods were evaluated for their ability to predict cocrystallization outcomes. The study also assessed the thermodynamic parameters and dissolution behavior of the newly obtained CBZ cocrystals.
Article
Chemistry, Physical
Uday Kumar Neelam, Bhatraju Daveedu, Vekariya Nagaji Ambabhai, Mahender Rao Siripragada, Satyasree Rajendra Kumar, Sridhar Balasubramanian
Summary: This study investigated the crystal forms of Voxelotor using crystallographic and solid-state characterization techniques, revealing the improved solubility and stability of VOX-HCl salt and VOX-SC cocrystal.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Jupally Prashanth, Ksenia Drozd, German L. Perlovich, Sridhar Balasubramanian, Artem Surov
Summary: Cocrystallization and coamorphization are two independent but similar approaches used to modify the physical properties of drug compounds. In this study, both methods were applied to the poorly soluble drug enzalutamide, resulting in the development of new multicomponent crystalline and amorphous solid forms. The cocrystal exhibited higher thermodynamic solubility, while the coamorphous form underwent recrystallization upon storage.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Shea Sanvordenker, Siddharth Borsadia, Steve Morris, Nair Rodriguez-Hornedo, Max Shtein
Summary: This study reports a novel process for the sublimation, transportation, and high-velocity directed deposition of pharmaceutical cocrystals, resulting in the formation of nano- and microscopic cocrystals. This touch-free, nonmechanical, single-step method enables particle size reduction and surface coating of cocrystals.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Srinivasulu Aitipamula, Loke Pei Shan, Krishna M. Gupta
Summary: The emergence of cocrystals as alternative solid forms for novel drug product development highlights the importance of polymorphism studies in cocrystals. Two novel polymorphs of a cocrystal involving an anti-inflammatory and antioxidative active ingredient, phloretin (PHL), and a pharmaceutically acceptable coformer, nicotinamide (NA), were structurally characterized. The study of these polymorphs and their phase transformations revealed the impact of polymorphism on the physicochemical properties of cocrystals, with Form I being the most stable under ambient conditions.
Article
Chemistry, Physical
Luan Farinelli Diniz, Juan Carlos Tenorio, Caue Ribeiro, Paulo de Sousa Carvalho Jr
Summary: This study focuses on the preparation and characterization of different salts of Sertraline (Srt) to improve its thermal stability and solubility. The crystal structures of the salts, including oxalate, fumarate, maleate, and methanesulfonate, were analyzed, and their potential applications in drug formulation and purification were discussed.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Yanjie Zhang, Yanguang Li, Lei Liu, Quanhu Guo, Rongjian Sa, Mei Zhang, Benyong Lou
Summary: Two polymorphic cocrystals of palmatine chloride with racemic hesperetin (Form I and Form II) were prepared and investigated, showing different supramolecular arrangements despite similar hydrogen-bonding interactions. Cocrystal formation decreases the solubility of palmatine chloride and improves the solubility of hesperetin, allowing for sustained release of palmatine chloride and enhanced release of hesperetin in pure water.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Pharmacology & Pharmacy
Artem O. Surov, Ksenia V. Drozd, Anna G. Ramazanova, Andrei V. Churakov, Anna V. Vologzhanina, Elizaveta S. Kulikova, German L. Perlovich
Summary: Polymorphism is a common phenomenon in molecular crystals and has a significant impact on drug development. This study obtained and characterized a new polymorphic form of the drug carbamazepine (CBZ) cocrystal with methylparaben (MePRB), as well as a channel-like cocrystal with highly disordered coformer molecules, using various analytical methods. The structural analysis revealed a close resemblance between the novel form II and previously reported form I of the [CBZ + MePRB] cocrystal. The discovered form II showed superior thermodynamic stability and dissolution performance, making it a more promising solid form for pharmaceutical development.
Article
Chemistry, Multidisciplinary
Jupally Prashanth, Artem O. Surov, Ksenia V. Drozd, German L. Perlovich, Sridhar Balasubramanian
Summary: Nilutamide is used in the treatment of prostate cancer. It was found that cocrystallization of nilutamide with adenine and orotic acid monohydrate resulted in the formation of four novel solid forms. The crystal structures were determined by X-ray diffraction, revealing the presence of multiple symmetry-independent molecules in two of the forms. The [Nil + Adn] cocrystal showed higher solubility compared to pure Nil.
Article
Chemistry, Multidisciplinary
Harsh S. Shah, Yuan Jiuchuang, Xie Tian, Yang Zhuocen, Chang Chao, Chandler Greenwell, Zeng Qun, Sun GuangXu, Brandon N. Read, Timothy S. Wilson, Henry U. Valle, Shanming Kuang, Wang Jian, Sivakumar Sekharan, Jessica F. Bruhn
Summary: Establishing the absolute configuration of chiral active pharmaceutical ingredients (APIs) is important. A method using microcrystal electron diffraction (MicroED) was developed to determine absolute configuration without the need for large crystals. This streamlined method involves virtual screening, experimental cocrystal screening, and structure determination by MicroED. It was successfully applied to analyze two chiral API molecules where single crystal X-ray diffraction was not used.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Jie Zhang, Rui Shen, Xu Zhang, Gen Li, Xi Wang
Summary: APG-PIP cocrystal with improved solubility and dissolution rate was successfully fabricated, indicating a different release pattern compared to parent APG.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Multidisciplinary
Kuntrapakam Hema, Cijil Raju, Subhrajyoti Bhandary, Kana M. Sureshan
Summary: The regiochemistry of topochemical reactions is determined by the crystal structure, and precise crystal engineering is required for biasing the regiochemistry. By designing and synthesizing crystals, as well as controlling the reaction conditions, targeted polymers can be selectively obtained.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Jay Makadia, Shadrack J. Madu, Randolph Arroo, Colin C. Seaton, Mingzhong Li
Summary: The study found that ART(2)-ACA cocrystals have higher solubility and a faster dissolution rate compared to the parent drug artemisinin.
Article
Chemistry, Multidisciplinary
Indumathi Sathisaran, Sameer Vishvanath Dalvi
Summary: The study describes the synthesis of new eutectic and cocrystal of Nevirapine with enhanced dissolution, demonstrating potential applications in biopharmaceuticals.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Engineering, Chemical
Wenjie Kuang, Shaochang Ji, Xiaofang Wang, Jinyan Zhang, Ping Lan
Summary: Pharmaceutical cocrystals are an alternative approach to synthesis of new solids, and in this study, two forms of cocrystals were synthesized and characterized. The properties of LTG were enhanced by cocrystal formation, with LTG-THP-H2O showing slower dissolution rate and higher stability compared to LTG-GLU. The selection of conformers is crucial for improving the performance of LTG.
Article
Geochemistry & Geophysics
Jeremy N. Bentley, G. Todd Ventura, Connor J. Dalzell, Clifford C. Walters, Carl A. Peters, Anthony S. Mennito, Robert K. Nelson, Christopher M. Reddy, Jeffrey S. Seewald, Stefan M. Sievert
Summary: Archaea, one of the earliest evolved organisms, have highly recalcitrant membrane lipids that are abundant in modern sediments but almost entirely absent in ancient rock records. A comprehensive study of archaeal lipids from a hydrothermal vent complex in Guaymas Basin revealed that the lipids mainly derive from methane-oxidizing archaea and anaerobic thermophilic methanogens. The preservation of archaeal lipids differs from other biomarkers, with a significant reduction in lipid content over time.
ORGANIC GEOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Susobhan Das, Subhankar Saha, Mrinmay Sahu, Amit Mondal, C. Malla Reddy
Summary: This study presents a rare example of a dynamic crystal involving the heavy transition metal rhenium, displaying initial two-face elasticity and elasto-plastic deformation at room temperature, followed by transformation into a rotator crystal phase at approximately 105 degrees C. The mechanical tests, X-ray diffraction, mu-Raman, and polarized light microscopy experiments reveal that the elasto-plastic deformation involves molecular rotations and slip, while malleability in the rotator phase is facilitated by reorientational motions and increased symmetry. Connecting plastically bendable crystals with rotator phases is important for designing multi-functional dynamic crystals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Subham Ranjan, Satoshi Takamizawa
Summary: In this work, two-dimensional ferroelasticity in 4-iodoaniline was observed under external stress, as investigated by force measurement and single-crystal X-ray diffraction techniques at macroscopic and microscopic levels.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Shreya Mahato, Amit Mondal, Mainak Das, Mayank Joshi, Partha Pratim Ray, Angshuman Roy Choudhury, C. Malla Reddy, Bhaskar Biswas
Summary: The study introduces a novel type of M(II)-Ce(IV) complex salts and highlights their potential in designing smart functional materials. Structural and morphological properties of the compounds are revealed through analytical and spectroscopic methods. The complex salts were utilized to construct Schottky devices to investigate their role in charge-transport phenomenon.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Shibani Mohata, Kaushik Dey, Surojit Bhunia, Neethu Thomas, E. Bhoje Gowd, Thalasseril G. Ajithkumar, C. Malla Reddy, Rahul Banerjee
Summary: Utilizing graphene as a grafting layer, a new method for preparing Janus-type COF-graphene thin films was proposed, demonstrating the fabrication of two distinct Janus-type films with heterogeneous surface morphologies and porosity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Environmental
Michael G. Mazzotta, Christopher M. Reddy, Collin P. Ward
Summary: The study found that marine microbes can degrade cellulose diacetate (CDA) based materials in a matter of months, challenging the belief that CDA-based materials persist in the ocean for decades. This discovery could lead to the identification of high-utility, biobased plastics with low environmental persistence.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Review
Chemistry, Analytical
Stephen A. Wise, Ryan P. Rodgers, Christopher M. Reddy, Robert K. Nelson, Elizabeth B. Kujawinski, Terry L. Wade, Andres D. Campiglia, Zhanfei Liu
Summary: Analytical techniques for chemical analysis of oil and its transformation products have greatly benefited from research following the Deepwater Horizon oil spill. Advanced gas chromatography and high-resolution mass spectrometry have provided a better understanding of the composition and complexity of oil, while novel separation approaches have increased the information available on spilled oil. The development of these techniques is important for future oil spills and investigations into the fate and effects of petroleum and dispersants.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Parag Roy, Nimmy Kumari, Noopur Pandey, Abhishek Gour, Amit Raj, B. Srividya, Utpal Nandi, Animesh Ghosh
Summary: The study prepared a pharmaceutical eutectic of ezetimibe with succinimide by mechanochemical grinding, showing improved solubility and oral bioavailability compared to pure ezetimibe. The eutectic can be utilized to develop ideal oral solid dosage formulations.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Parag Roy, Noopur Pandey, Animesh Ghosh
Summary: Molecular docking is an effective tool for predicting therapeutic activities of molecules in drug design. Recent reports have focused on the docking of cocrystals and their potential biological activities. However, regulatory bodies do not consider cocrystals as new entities, so docking studies using them as ligands instead of the parent API are not relevant.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Daliya K. Shajan, Noopur Pandey, Animesh Ghosh, Hemanth Kumar Chanduluru, Palash Sanphui
Summary: This study successfully prepared three anhydrous cocrystals and three hydrate cocrystals using methods such as solvent-assisted grinding. The cocrystals were characterized through various techniques. The hydrogen bonding patterns between OBV and ECB in the cocrystals were similar to the ECB-benzoic acid cocrystal. The solubility and diffusion properties of the cocrystals were reduced compared to the native drug, mainly due to decreased concentration gradient and hydrophobic interactions.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Subham Ranjan, Meguya Ryu, Ryota Morioka, Shuji Kamegaki, Soon Hock Ng, Daniel Smith, Jitraporn Vongsvivut, Mark J. Tobin, Saulius Juodkazis, Junko Morikawa, Satoshi Takamizawa
Summary: A unique scissor-like two-directional ferroelastic deformation was achieved in organic crystals, shedding light on the understanding of multidirectional deformations in organic compounds. The study also revealed a correlation between the anisotropic structural arrangement and the difference in thermal diffusivity and mechanical behavior.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
S. Richu Bagya Varsa, Noopur Pandey, Animesh Ghosh, Anubha Srivastava, Pavan Kumar Puram, Sai Teja Meka, Vladimir V. Chernyshev, Palash Sanphui
Summary: By synthesizing novel solid drugs containing maleic acid and oxalic acid salts, the solubility and diffusion permeability of allopurinol can be improved, thereby enhancing its pharmacokinetics and bioavailability.
Article
Chemistry, Physical
Akira Kobayashi, Jun Yamagami, Subham Ranjan, Satoshi Takamizawa, Hisashi Honda
Summary: This study provides the first evidence that lithium ions can form ionic plastic crystals using crown ether with a bis-(trifluoromethanesulphonyl) amide (TFSA) anion. Various measurements, including nuclear-magnetic-resonance, X-ray diffraction, and electrical conductivity, were conducted to investigate the properties of these crystals. The study also discovered new rotator crystals and estimated the activation energies of molecular motions in the crystals.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Subham Ranjan, Hisashi Honda, Satoshi Takamizawa
Summary: The advent of exclusive mechanical deformations in organic compounds has opened up opportunities to explore intriguing mechanical properties in organic molecules. This paper reports a supramolecular organic salt exhibiting a shape memory effect with superelastic and ferroelastic interconversion upon external stimuli. The structural changes at the macroscopic and molecular level were elucidated using various techniques.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Materials Science, Multidisciplinary
Avantika Hasija, Subham Ranjan, Sarah Guerin, S. R. N. Kiran Mangalampalli, Satoshi Takamizawa, Deepak Chopra
Summary: This article introduces a polymorphic organic salt that exhibits both thermoresponsive and mechanoresponsive behavior at different temperatures. The study reveals that the single crystalline form of this salt displays reversible phase transformation, shape memory effect, and mechanical flexibility. By conducting experiments and calculations, the research reveals the differences in elastic modulus and resistance to elastic deformation among different forms of the salt.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
