The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer’s-Related Pathology via HMGB1 Inhibition

Attenuation of neuroinflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway in a rat tibial fracture model

(2016) Ya-Juan Zhu et al.   BRAIN RESEARCH

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

(2016) Laura K. Fonken et al.   JOURNAL OF NEUROSCIENCE

Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity

(2016) W. Wang et al.   NEUROSCIENCE

Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats

(2016) Niccolò Terrando et al.   Frontiers in Immunology

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease

(2016) Kyota Fujita et al.   Scientific Reports

Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats

(2015) Iris B. Hovens et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering β-Amyloid Accumulation via the Transforming Growth Factor-β (TGFβ)/Smad Signaling Pathway

(2015) Ayong Tian et al.   PLoS One

Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning

(2014) Iris B. Hovens et al.   BRAIN BEHAVIOR AND IMMUNITY

Glycyrrhizin protects brain against ischemia–reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway

(2014) Jiancheng Zhang et al.   BRAIN RESEARCH

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice

(2014) Zhipeng Xu et al.   Scientific Reports

Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats

(2013) Zheng-Qian Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The neuroinflammatory response of postoperative cognitive decline

(2013) S. Vacas et al.   BRITISH MEDICAL BULLETIN

High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4

(2013) Melissa D. Laird et al.   GLIA

Postoperative cognitive dysfunction, Alzheimer's disease, and anesthesia

(2013) Sona S. Arora et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

High-mobility group box 1 protein (HMGB1) neutralization ameliorates experimental autoimmune encephalomyelitis

(2013) Andrew P. Robinson et al.   JOURNAL OF AUTOIMMUNITY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE

(2013) Rui-Lin Li et al.   JOURNAL OF SURGICAL RESEARCH

The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats

(2013) YI WANG et al.   Molecular Medicine Reports

Glycyrrhizin Alleviates Neuroinflammation and Memory Deficit Induced by Systemic Lipopolysaccharide Treatment in Mice

(2013) Jeong-Ho Song et al.   MOLECULES

Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation

(2013) Wen-Jie Jin et al.   NEUROREPORT

Role of Peripheral Inflammatory Markers in Postoperative Cognitive Dysfunction (POCD): A Meta-Analysis

(2013) Linying Peng et al.   PLoS One

Perioperative inflammatory response and protein S-100β concentrations - relationship with post-operative cognitive dysfunction in elderly patients

(2012) Y-C. LI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Tau Phosphorylation and Sevoflurane Anesthesia

(2012) Hélène Le Freche et al.   ANESTHESIOLOGY

Anti-high mobility group box-1 antibody therapy for traumatic brain injury

(2012) Yu Okuma et al.   ANNALS OF NEUROLOGY

The Blood–Brain Barrier Permeability of 18β-Glycyrrhetinic Acid, a Major Metabolite of Glycyrrhizin in Glycyrrhiza Root, a Constituent of the Traditional Japanese Medicine Yokukansan

(2012) Masahiro Tabuchi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Surgery Upregulates High Mobility Group Box-1 and Disrupts the Blood-Brain Barrier causing Cognitive Dysfunction in Aged Rats

(2012) Hui-Juan He et al.   CNS Neuroscience & Therapeutics

Meloxicam improves object recognition memory and modulates glial activation after splenectomy in mice

(2012) Angela R. Kamer et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury

(2012) Philip F. Stahel   Journal of Trauma and Acute Care Surgery

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

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(2012) Sangeeta Chavan et al.   MOLECULAR MEDICINE

HMGB1 in Development and Diseases of the Central Nervous System

(2012) Ping Fang et al.   MOLECULAR NEUROBIOLOGY

Human Alzheimer and Inflammation Biomarkers after Anesthesia and Surgery

(2011) Junxia X. Tang et al.   ANESTHESIOLOGY

Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats

(2011) Weiran Liu et al.   NEUROLOGICAL RESEARCH

Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s disease

(2010) V. Fodale et al.   ANAESTHESIA

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice

(2010) Yanjie Wan et al.   CRITICAL CARE MEDICINE

Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-κB expression

(2010) Lina Wang et al.   NEUROSCIENCE LETTERS

Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats

(2010) Xue-Zhao Cao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cognitive dysfunction after surgery and anaesthesia: what can we tell the grandparents?

(2009) D. G. Seymour et al.   AGE AND AGEING

Predictors of Cognitive Dysfunction after Major Noncardiac Surgery

(2009) Terri G. Monk et al.   ANESTHESIOLOGY

Targeting HMGB1 in inflammation

(2009) Huan Yang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Postoperative delirium and cognitive dysfunction

(2009) S. Deiner et al.   BRITISH JOURNAL OF ANAESTHESIA

Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic?

(2009) Robert D Sanders et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Inflammation: A bridge between postoperative cognitive dysfunction and Alzheimer’s disease

(2009) Zhonghua Hu et al.   MEDICAL HYPOTHESES