Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance

Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

(2017) Subramanyam J. Tantry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting the synthetic lethality between terminal respiratory oxidases to killMycobacterium tuberculosisand clear host infection

(2017) Nitin P. Kalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Energy Metabolism in Mycobacterium tuberculosis , a New Paradigm in Antimycobacterial Drug Discovery

(2017) Dirk Bald et al.   mBio

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

(2016) Daniel T. Hoagland et al.   ADVANCED DRUG DELIVERY REVIEWS

Mutations inpepQConfer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis

(2016) Deepak Almeida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Total Synthesis and Stereochemical Revision of the Anti-Tuberculosis Peptaibol Trichoderin A

(2016) Iman Kavianinia et al.   ORGANIC LETTERS

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

(2016) Josephine M. Bryant et al.   SCIENCE

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors

(2016) Narisa Phummarin et al.   MedChemComm

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2016) Kenia Pissinate et al.   ACS Medicinal Chemistry Letters

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

(2016) Dirk A. Lamprecht et al.   Nature Communications

Arrival of Imidazo[2,1-b]thiazole-5-carboxamides: Potent Anti-tuberculosis Agents That Target QcrB

(2016) Garrett C. Moraski et al.   ACS Infectious Diseases

Putative 3D Structure of QcrB fromMycobacterium tuberculosisCytochromebc1 Complex, a Novel Drug-Target for New Series of Antituberculosis Agent Q203

(2016) Yoonae Ko et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis

(2015) Supriya Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution

(2015) Tobias Bollenbach   CURRENT OPINION IN MICROBIOLOGY

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

(2015) Renier van der Westhuyzen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis

(2015) Guido V. Bloemberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

(2015) Wilfried Moreira et al.   mBio

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

(2015) Jan Rybniker et al.   Nature Communications

Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

(2015) Garrett C. Moraski et al.   ACS Infectious Diseases

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?

(2015) Stephen K. Field   Therapeutic Advances in Chronic Disease

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress

(2015) Ping Lu et al.   Scientific Reports

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

(2014) R. C. Hartkoorn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Efflux Pump Inhibitor Timcodar Improves the Potency of Antimycobacterial Agents

(2014) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Verapamil Increases the Bactericidal Activity of Bedaquiline against Mycobacterium tuberculosis in a Mouse Model

(2014) Shashank Gupta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Respiratory Flexibility in Response to Inhibition of CytochromecOxidase in Mycobacterium tuberculosis

(2014) Kriti Arora et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP synthase in mycobacteria: Special features and implications for a function as drug target

(2014) Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

(2014) Jan Rybniker et al.   Cell Host & Microbe

High cure rate with standardised short-course multidrug-resistant tuberculosis treatment in Niger: no relapses

(2014) A. Piubello et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Bactericidal Activity of an Imidazo[1, 2-a]pyridine Using a Mouse M. tuberculosis Infection Model

(2014) Yong Cheng et al.   PLoS One

Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

(2014) Koen Andries et al.   PLoS One

Future target-based drug discovery for tuberculosis?

(2014) Bavesh Davandra Kana et al.   TUBERCULOSIS

The Mycobacterial Cell Envelope--Lipids

(2014) M. Jackson   Cold Spring Harbor Perspectives in Medicine

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

(2013) Shashank Gupta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Operation mechanism of FoF1-adenosine triphosphate synthase revealed by its structure and dynamics

(2013) Ryota Iino et al.   IUBMB LIFE

Escherichia coliF1Fo-ATP Synthase with a b/δ Fusion Protein Allows Analysis of the Function of the Individual b Subunits

(2013) Chathurada S. Gajadeera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

(2013) Katherine A. Abrahams et al.   PLoS One

Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

(2013) Robert C. Goldman   TUBERCULOSIS

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

(2012) Puiying A. Mak et al.   ACS Chemical Biology

New Mutations in the Mycobacterial ATP Synthase: New Insights into the Binding of the Diarylquinoline TMC207 to the ATP Synthase C-Ring Structure

(2012) Elena Segala et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural analysis of cytochrome bc1 complexes: Implications to the mechanism of function

(2012) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Tuberculosis: The drug development pipeline at a glance

(2012) Baptiste Villemagne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

X-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution

(2011) Thomas Kleinschroth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Action-Mechanism of Trichoderin A, an Anti-dormant Mycobacterial Aminolipopeptide from Marine Sponge-Derived Trichoderma sp.

(2011) Patamaporn Pruksakorn et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors

(2011) Carolyn K. Dong et al.   CHEMISTRY & BIOLOGY

New regimens for reducing the duration of treatment of drug-susceptible pulmonary tuberculosis

(2011) Marcus B. Conde et al.   DRUG DEVELOPMENT RESEARCH

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

(2011) P. E. Almeida Da Silva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase

(2011) Anna C. Haagsma et al.   PLoS One

High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv

(2011) Robert C. Reynolds et al.   TUBERCULOSIS

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

(2011) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

(2011) Shinya Watanabe et al.   PLoS Pathogens

Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis

(2010) Armand Van Deun et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Letting Sleeping dos Lie: Does Dormancy Play a Role in Tuberculosis?

(2010) Michael C. Chao et al.   Annual Review of Microbiology

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

(2010) Patamaporn Pruksakorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

(2010) Dirk Bald et al.   FEMS MICROBIOLOGY LETTERS

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

ATP Synthase Inhibition of Mycobacterium avium Is Not Bactericidal

(2009) N. Lounis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor

(2009) E. Huitric et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

(2009) Caroline Demangel et al.   NATURE REVIEWS MICROBIOLOGY

High-resolution structure of the rotor ring of a proton-dependent ATP synthase

(2009) Denys Pogoryelov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unique Rotary ATP Synthase and Its Biological Diversity

(2008) Christoph von Ballmoos et al.   Annual Review of Biophysics

Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue

(2008) A. C. Haagsma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5–MmpL5 efflux system

(2008) Anna Milano et al.   TUBERCULOSIS

Review: Managing TB in the 21st century: existing and novel drug therapies

(2008) Elizabeth S. Guy et al.   Therapeutic Advances in Respiratory Disease

Determination of Global Protein Turnover in Stressed Mycobacterium Cells Using Hybrid-Linear Ion Trap-Fourier Transform Mass Spectrometry

(2007) Prahlad K. Rao et al.   ANALYTICAL CHEMISTRY

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

(2007) Frederik A.J. Rotsaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS