期刊
SCIENCE
卷 354, 期 6313, 页码 751-757出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf8156
关键词
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资金
- Wellcome Trust [098051, 107032AIA]
- Medical Research Council
- UK Cystic Fibrosis Trust
- Papworth Hospital
- National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre
- NIHR Specialist Respiratory Biomedical Research Unit, Imperial College London
- UK Clinical Research Collaboration Translational Infection Research Initiative
- CF Foundation Therapeutics grant
- Australian National Health and Medical Research Council
- National Services Division
- NHS Scotland
- European Nucleotide Archive [ERP001039]
- National Research Ethics Service (NRES) [12/EE/0158]
- National Information Governance Board (NIGB) [ECC 3-03 (f)/2012]
- Scottish centers from NHS Scotland Multiple Board Caldicott Guardian Approval (NHS Tayside AR/SW)
- Wellcome Trust [107032/Z/15/Z] Funding Source: Wellcome Trust
- Cystic Fibrosis Trust [PJ561, SRC002] Funding Source: researchfish
- Medical Research Council [974668, G1001712] Funding Source: researchfish
- National Institute for Health Research [CL-2006-13-003] Funding Source: researchfish
- Wellcome Trust [107032/Z/15/Z] Funding Source: researchfish
- MRC [G1001712] Funding Source: UKRI
Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.
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