Article
Biochemistry & Molecular Biology
Yixin Luo, Bingyu Pang, Junfeng Hao, Qingyang Li, Pei Qiao, Chen Zhang, Yaxing Bai, Chunying Xiao, Jiaoling Chen, Dalong Zhi, Ying Liu, Erle Dang, Gang Wang, Bing Li
Summary: The dysregulated glucose metabolism in psoriasis is influenced by the cytoskeletal protein keratin 17 (K17) and its interaction partner & alpha;-enolase (ENO1). Increased K17 expression activates the glycolytic pathway in psoriatic keratinocytes (KCs). Inhibition of ENO1 or K17-Ser44 phosphorylation suppresses glycolysis and proliferation in KCs. Modulation of the ENO1-K17-LDHA axis could be a potential therapeutic approach for psoriasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pei Qiao, Dalong Zhi, Chen Yu, Chen Zhang, Kunyi Wu, Hui Fang, Shuai Shao, Wen Yin, Erle Dang, Ke Li, Gang Wang
Summary: Studies have shown that C3aR plays a protective role in psoriasis by negatively regulating the expression of K6, K16, and K17 in keratinocytes to inhibit cell proliferation and help reverse the progression of the disease.
Article
Endocrinology & Metabolism
Yongjun Chen, Nian Shi, Hui Mao, Cuilin Xie
Summary: This study investigates the correlation between interleukin 6 (IL-6) and Keratin 17 (K17) expression in psoriasis. The researchers found that IL-6 promotes psoriasis through the JAK/PI3K/AKT pathway. These findings suggest that the JAK/PI3K/AKT pathway could be a potential target for psoriasis treatment.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Multidisciplinary Sciences
Wei Han, Chan Hu, Zhao-Jun Fan, Guo-Liang Shen
Summary: In this study, the diverse expression patterns and prognostic values of keratins (KRTs) in melanoma were investigated, revealing differential expression of KRT1/2/5/6/10/14/15/16/17 between primary and metastatic melanoma and their correlation with advanced tumor stage and overall survival in patients. Pathway analysis identified involvement of P53 pathway, KRAS signaling, estrogen response early and late in melanoma, along with correlations between KRT expression and immune cell infiltration.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Textiles
Marek Konop, Mateusz Rybka, Mateusz Szudzik, Lukasz Mazurek, Anna K. Laskowska, Dorota Sulejczak, Zbigniew Ruszczak, Rafal Mazgaj, Bartlomiej Cieslik, Robert A. Schwartz, Emilia Samborowska, Jakub Frankowski, Adam Waszkowski, Piotr Konopelski, Joanna Czuwara
Summary: This study evaluated the effect of keratin-butyrate fibers on skin wound healing in diabetic rats. The results showed that the keratin-butyrate dressing accelerated wound healing, stimulated tissue remodeling and regeneration, and supported cell growth without toxicity.
JOURNAL OF NATURAL FIBERS
(2023)
Review
Cell Biology
Yiting Lin, Weigang Zhang, Bing Li, Gang Wang
Summary: Keratin 17 (K17) is overexpressed in psoriasis and plays a key role in the pathogenesis of the disease. It has both pro-proliferative and pro-inflammatory effects on keratinocytes and triggers autoreactive T cells and psoriasis-related cytokine production. The expression, stability, and protein-protein interactions of K17 are regulated by cytokines through transcriptional, translational, and post-translational modification processes. Targeting K17 has shown positive outcomes in psoriasis-like mouse models, suggesting a potential therapeutic approach. The future perspectives of K17 in psoriasis are also discussed for further studies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Donghee Kim, Hyo-Jin Kim, Jin-Ok Baek, Joo-Young Roh, Hee-Sook Jun
Summary: The study revealed that LPAR1/3 antagonist alleviates IMQ-induced psoriasis-like symptoms in mice, with LPAR1 signaling playing a crucial role in cell cycle progression in keratinocytes via the ROCK2/PI3K/AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ting Zhou, Shihan Zhang, Yingli Zhou, Simin Lai, Yanjiong Chen, Yan Geng, Jing Wang
Summary: Recent studies have shown that PGRN deficiency exacerbates psoriatic skin lesions, while treatment with curcumin can alleviate the deterioration caused by PGRN deficiency in psoriatic skin lesions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Dora Antal, Agnes Por, Ilona Kovacs, Katalin Dull, Szilard Poliska, Gyula Ujlaki, Mate agoston Demeny, Attila Gabor Szollosi, Borbala Kiss, Andrea Szegedi, Peter Bai, Magdolna Szanto
Summary: This study found that PARP2 mRNA expression is increased in human psoriatic lesions. Through experiments in mouse and human cell models, we found that inhibition of PARP2 expression can alleviate psoriasis-like dermatitis by suppressing inflammation in keratinocytes through inhibition of estrogen biosynthesis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Immunology
Caifeng Chen, Li Chen, Jun Zhou, Renhui Cai, Zhenjie Ye, Danqun Zhang
Summary: This study explored the anti-proliferative activity and anti-inflammatory responses of hydroxytyrosol (HT) in psoriatic keratinocytes. The results showed that HT exerted potent anti-inflammatory effects and inhibited cell proliferation in psoriasis cell model. This suggests that HT may be a promising therapeutic agent in psoriasis treatment.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Shu-min Kong, Xiao-yan Sun, Wen-ya Cui, Yu-chun Cao
Summary: This study aims to determine the role of chemerin in the pathogenesis of psoriasis. The results show that chemerin enhances keratinocyte proliferation and increases the production of inflammatory cytokines, thereby aggravating the symptoms of psoriasis. Therefore, chemerin may be a promising target for the treatment of psoriasis.
CURRENT MEDICAL SCIENCE
(2023)
Article
Medical Laboratory Technology
Xu Yang, Haosheng Chen, Hong Zheng, Kang Chen, Pingyuan Cai, Lei Li, Keqian Li, Yang Du, Xiang Chun He
Summary: LncRNA SNHG12 regulates the development of osteoarthritis (OA) by inhibiting miR-16-5p expression in chondrocytes, potentially serving as a therapeutic and diagnostic target for OA.
CLINICAL LABORATORY
(2022)
Article
Developmental Biology
Atrayee Basu, Sibaram Behera, Smriti Bhardwaj, Shirshendu Dey, Anindya Ghosh-Roy
Summary: The adult nervous system has limited capacity to regenerate after accidental damage, requiring proper targeting of the injured axon to its postsynaptic cell. Coordinated insulin signaling activities in neuron and muscle promote "ventral targeting" for functional recovery. This study reveals the important role of insulin signaling in regulating axon guidance molecules during the functional rewiring process.
Article
Biochemistry & Molecular Biology
Zhiwei Weng, Hangjie Fu, Zhiguang Huang, Wenxia Li, Yixin Xie, Jianchang Yuan, Bin Ding
Summary: Shikonin (SHK) has been proven to be beneficial for psoriasis by inhibiting ferroptosis through reducing inflammation, improving oxidative stress, and iron accumulation. The study suggests that Nrf2 and GPX4 may be the two main targets of SHK in psoriatic skin lesions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Applied
Qinyue Xie, Jianhong Yang, Feifei Pan, Jun Cai
Summary: This study evaluated the wound healing performance of 6-carboxyl chitin, which was found to promote the proliferation of human skin fibroblasts and keratinocytes depending on concentration and molecular weight. The optimal conditions observed were 10-40 kDa and 10-100 μg/mL for fibroblast proliferation, while keratinocyte proliferation increased with lower concentration and molecular weight. Additionally, 6-carboxyl chitins were able to induce the secretion of growth factors by macrophages and fibroblasts, indicating potential as an active ingredient for wound healing.
CARBOHYDRATE POLYMERS
(2021)
Article
Dermatology
L. Yang, T. Zhang, C. Zhang, C. Xiao, X. Bai, G. Wang
Summary: This study reveals the essential role of Trim21 in mediating keratinocyte inflammation in psoriasis by ubiquitinating p65 and activating the NF-kappa B pathway. Targeting Trim21 may present a promising approach for psoriasis treatment.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Xiaocui Bai, Chen Yu, Luting Yang, Yixin Luo, Dalong Zhi, Gang Wang, Erle Dang
EUROPEAN JOURNAL OF DERMATOLOGY
(2020)
Article
Dermatology
Erle Dang, George Man, Jiechen Zhang, Dale Lee, Theodora M. Mauro, Peter M. Elias, Mao-Qiang Man
EXPERIMENTAL DERMATOLOGY
(2020)
Article
Dermatology
Lin Gao, Li Wang, Kai Li, Qiang Tan, Erle Dang, Meiheng Lu, Yan Li, Wenbin Tan, Gang Wang
Summary: This study demonstrated that triple therapy is effective for the treatment of acne and should be further evaluated and investigated.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Man Jiang, Hui Fang, Erle Dang, Jieyu Zhang, Pei Qiao, Chen Yu, Angang Yang, Gang Wang
Summary: Psoriatic keratinocytes transfer miR-381-3p to CD4(+)T cells through small extracellular vesicles (sEVs), inducing Th1 and Th17 polarization and promoting psoriasis development.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Luting Yang, Chen Zhang, Xiaocui Bai, Chunying Xiao, Erle Dang, Gang Wang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Dermatology
Jiaoling Chen, Zhenlai Zhu, Qingyang Li, Yiting Lin, Erle Dang, Hua Meng, Nanxi Sha, Hua Bai, Gang Wang, Shujie An, Shuai Shao
Summary: Neutrophil infiltration and papillary vessel dilation are characteristic features of the initiation phase of psoriatic lesions. Our study found that neutrophils activate cutaneous vascular endothelial cells, leading to vascular remodeling, vasodilation, and enhanced vascular permeability both in vivo and in vitro. Furthermore, MMP-9 secreted by psoriatic neutrophils activates vascular endothelial cells and enhances CD4(+) T-cell transmigration, facilitating the development of psoriatic lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Erle Dang, George Man, Dale Lee, Debbie A. Crumrine, Theodora M. Mauro, Peter M. Elias, Mao-Qiang Man
Summary: The deficiency of 3 beta-hydroxysteroid-delta 8, delta 7-isomerase does not compromise epidermal permeability barrier in mice, suggesting compensatory mechanisms through other pathways. Whether these findings can be extrapolated to humans remains to be determined.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell Biology
Chen Zhang, ZhenLai Zhu, JiXin Gao, LuTing Yang, ErLe Dang, Hui Fang, Shuai Shao, ShaoLong Zhang, ChunYing Xiao, Xu Yuan, Wei Li, Riichiro Abe, HongJiang Qiao, Gang Wang, Meng Fu
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Oncology
Shuya Yang, Yuanjie Sun, Dongbo Jiang, Jing Wang, Erle Dang, Zichao Li, Jiayi Zhou, Yuchen Lu, Jingqi Shi, Liang Tao, Jun Wang, Boquan Jin, Lianhe Zheng, Kun Yang
Summary: Elevated BAP31 in cervical cancer is regulated by miR-362, which inhibits cell proliferation and promotes apoptosis, ultimately suppressing tumor progression. The BAP31/SPTBN1 complex modulates tumor progression through the Smad 2/3 pathway under miR-362 regulation.
Article
Medicine, General & Internal
Lin Gao, Wei Wen, Yuanli Wang, Zhaoyang Li, Erle Dang, Lei Yu, Chenxi Zhou, Meiheng Lu, Gang Wang
Summary: Fractional CO2 vaginal laser treatment can improve vaginal health and sexual function, and restore vaginal biomechanical properties by increasing vaginal tissue tightening and improving vaginal tissue integrity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Hui Fang, Qingyang Li, Gang Wang
AUTOIMMUNITY REVIEWS
(2020)