Induction and Differentiation of IL-10–Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients

BIP induces mice CD19 hi regulatory B cells producing IL-10 and highly expressing PD-L1, FasL

(2016) Youfa Tang et al.   MOLECULAR IMMUNOLOGY

CD24hiCD27+ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease

(2015) A. de Masson et al.   BLOOD

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Regulatory B10 cell development and function: Fig. 1.

(2015) Jacquelyn M. Lykken et al.   INTERNATIONAL IMMUNOLOGY

Regulatory B cells in human inflammatory and autoimmune diseases: from mouse models to clinical research

(2015) Tomomitsu Miyagaki et al.   INTERNATIONAL IMMUNOLOGY

The expanding family of regulatory B cells

(2015) Claudia Mauri et al.   INTERNATIONAL IMMUNOLOGY

B10 Cells: A Functionally Defined Regulatory B Cell Subset

(2015) Thomas F. Tedder   JOURNAL OF IMMUNOLOGY

Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts

(2014) Guido Heine et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance

(2014) Kang Mi Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B-type suppression: A role played by “regulatory B cells” or “regulatory plasma cells”?

(2014) Stefanie Ries et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells

(2014) Bi-Sheng Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation

(2014) Masanori Matsumoto et al.   IMMUNITY

The immune potential and immunopathology of cytokine-producing B cell subsets: A comprehensive review

(2014) Yan Bao et al.   JOURNAL OF AUTOIMMUNITY

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Regulatory B cells—IL-35 and IL-21 regulate the regulators

(2014) Thomas F. Tedder et al.   Nature Reviews Rheumatology

B Cells in Rheumatoid Arthritis: From Pathogenic Players to Disease Biomarkers

(2014) Serena Bugatti et al.   Biomed Research International

Regulatory B10 Cells Are Decreased in Patients With Rheumatoid Arthritis and Are Inversely Correlated With Disease Activity

(2014) Claire I. Daien et al.   Arthritis & Rheumatology

IL-21 Enhances the Activity of the TLR-MyD88-STAT3 Pathway but Not the Classical TLR-MyD88-NF- B Pathway in Human B Cells To Boost Antibody Production

(2013) B.-S. Liu et al.   JOURNAL OF IMMUNOLOGY

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

IL-10-producing regulatory B cells (B10 cells) in autoimmune disease

(2013) Ioannis Kalampokis et al.   ARTHRITIS RESEARCH & THERAPY

IL-10–Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation

(2012) Min Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Progression of joint damage despite control of inflammation in rheumatoid arthritis: a role for cartilage damage driven synovial fibroblast activity: Figure 1

(2012) Floris PJG Lafeber et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

(2012) Haifa H Jabara et al.   NATURE IMMUNOLOGY

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

(2012) Natalie A Carter et al.   ARTHRITIS RESEARCH & THERAPY

Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

(2011) Aharon Kessel et al.   AUTOIMMUNITY REVIEWS

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

(2011) Qing Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory B10 Cells Differentiate into Antibody-Secreting Cells After Transient IL-10 Production In Vivo

(2011) D. Maseda et al.   JOURNAL OF IMMUNOLOGY

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

(2009) Natalia Wegner et al.   IMMUNOLOGICAL REVIEWS

Killer B lymphocytes: the evidence and the potential

(2009) Steven K. Lundy   INFLAMMATION RESEARCH

The Induction of IL-10 by Zymosan in Dendritic Cells Depends on CREB Activation by the Coactivators CREB-Binding Protein and TORC2 and Autocrine PGE2

(2009) Y. Alvarez et al.   JOURNAL OF IMMUNOLOGY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

The effects of IL-6 on CD4 T cell responses

(2008) Oliver Dienz et al.   CLINICAL IMMUNOLOGY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression

(2008) Takashi Matsushita et al.   JOURNAL OF CLINICAL INVESTIGATION