Article
Microbiology
Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O'Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
Summary: Despite research focus on CD4 T cells in Mtb infections, little is known about Mtb-specific T cells within lung granulomas. We identified immunodominant epitopes for two Mtb proteins using a macaque model, facilitating the identification of Mtb-specific cells. Granulomas were found to be enriched sites for Mtb-specific cells, which expressed activation markers and transcription factors. Our data highlighted the importance of activated, polarized Mtb-specific cells for controlling Mtb in lung granulomas.
Article
Chemistry, Medicinal
Joshua T. Mattila, Wissam Beaino, Alexander G. White, Lea Nyiranshuti, Pauline Maiello, Jaime Tomko, L. James Frye, Daniel Fillmore, Charles A. Scanga, Philana Ling Lin, JoAnne L. Flynn, Carolyn J. Anderson
Summary: Neutrophilic inflammation is associated with severe tuberculosis caused by Mycobacterium tuberculosis. A specific PET probe targeting neutrophils has been tested in macaques, showing correlation with granulomas and potential applications in TB imaging but with some issues to be addressed before human use.
ACS INFECTIOUS DISEASES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinming Zhang, Yi Liao, Xiawan Wang, Teng Zhang, Jianhua Feng, Jianing Deng, Kexin Shi, Lin Chen, Liu Feng, Mindi Ma, Le Xue, Haifeng Hou, Xiaofeng Dou, Congcong Yu, Lei Ren, Yao Ding, Yufei Chen, Shuang Wu, Zexin Chen, Hong Zhang, Cheng Zhuo, Mei Tian
Summary: The study developed a novel deep learning framework for accurate and efficient identification of epileptic foci in pediatric patients with temporal lobe epilepsy, outperforming traditional visual assessment and other analysis methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neuroimaging
Catherine Sharpe, Benjamin Sinclair, Patrick Kwan, Rodney J. Hicks, Terence J. O'Brien, Lucy Vivash
Summary: In this study, repeated [F-18]-FDG PET scans of patients with drug-resistant TLE showed no significant changes in normalized [F-18]-FDG uptake in the hippocampi and temporal lobes over time. Some patients exhibited increased metabolism in the ipsilateral temporal lobe, but no areas of decreased metabolism corresponding to the epileptogenic zone were identified.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Public, Environmental & Occupational Health
Chao Wang, Xueli Yang, Honglu Zhang, Yanzhuo Zhang, Jianfeng Tao, Xu Jiang, Chengai Wu
Summary: This study aims to explore the long-term trends in high fasting plasma glucose (HFPG)-related tuberculosis (TB) mortality in China from 1990 to 2019. The study found that the mortality rates due to HFPG-related TB have decreased over the last 30 years in China, with similar trends observed in both men and women. However, effective strategies for glycemic control and management still need to be implemented to further decrease the burden of TB.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Katsuo Usuda, Shun Iwai, Aika Yamagata, Yoshihito Iijima, Nozomu Motono, Munetaka Matoba, Mariko Doai, Sohsuke Yamada, Yoshimichi Ueda, Keiya Hirata, Hidetaka Uramoto
Summary: The study examined the efficacy of DWI and FDG-PET/CT for assessing suture recurrence and suture granuloma after lung cancer resection. The findings suggest that DWI is more useful than FDG-PET/CT in differentiating between suture recurrence and suture granuloma.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Respiratory System
Neetu Soni, Manish Ora, Sarika Gupta, Ravishankar Pillenahalli Maheshwarappa, Sarv Priya, Michael M. Graham
Summary: A 44-year-old male was referred to our clinic in 2015 for evaluation of multiple lung nodules, fatigue, dyspnea, and weight loss. After various imaging studies and surgeries, he was diagnosed with pulmonary hyalinizing granuloma. Currently, he is undergoing evaluation for a lung transplant.
Article
Microbiology
G. L. Drusano, Jenny Myrick, Michael Maynard, Jocelyn Nole, Brandon Duncanson, David Brown, Stephan Schmidt, Michael Neely, C. A. Scanga, Charles Peloquin, Arnold Louie
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Biochemical Research Methods
Theodore R. Mellors, Mavra Nasir, Flavio A. Franchina, Agnieszka Smolinska, Lionel Blanchet, JoAnne L. Flynn, Jaime Tomko, Melanie O'Malley, Charles AScanga, Philana Ling Lin, Jeff Wagner, Jane E. Hill
JOURNAL OF BREATH RESEARCH
(2019)
Article
Immunology
Mark A. Rodgers, Cassaundra Ameel, Amy L. Ellis-Connell, Alexis J. Balgeman, Pauline Maiello, Gabrielle L. Barry, Thomas C. Friedrich, Edwin Klein, Shelby L. O'Connor, Charles A. Scanga
INFECTION AND IMMUNITY
(2018)
Article
Immunology
Patricia A. Darrah, Robert M. DiFazio, Pauline Maiello, Hannah P. Gideon, Amy J. Myers, Mark A. Rodgers, Joshua A. Hackney, Thomas Lindenstrom, Thomas Evans, Charles A. Scanga, Victor Prikhodko, Peter Andersen, Philana Ling Lin, Dominick Laddy, Mario Roederer, Robert A. Seder, JoAnne L. Flynn
Article
Multidisciplinary Sciences
Patricia A. Darrah, Joseph J. Zeppa, Pauline Maiello, Joshua A. Hackney, Marc H. Wadsworth Ii, Travis K. Hughes, Supriya Pokkali, Phillip A. Swanson, Nicole L. Grant, Mark A. Rodgers, Megha Kamath, Chelsea M. Causgrove, Dominick J. Laddy, Aurelio Bonavia, Danilo Casimiro, Philana Ling Lin, Edwin Klein, Alexander G. White, Charles A. Scanga, Alex K. Shalek, Mario Roederer, JoAnne L. Flynn, Robert A. Seder
Article
Microbiology
Amy L. Ellis, Alexis J. Balgeman, Erica C. Larson, Mark A. Rodgers, Cassaundra Ameel, Tonilynn Baranowski, Nadean Kannal, Pauline Maiello, Jennifer A. Juno, Charles A. Scanga, Shelby L. O'Connor
Article
Microbiology
G. L. Drusano, Brandon Duncanson, C. A. Scanga, S. Kim, S. Schmidt, M. N. Neely, W. M. Yamada, Michael Vicchiarelli, C. A. Peloquin, Arnold Louie
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
Amy L. Hartman, Sham Nambulli, Cynthia M. McMillen, Alexander G. White, Natasha L. Tilston-Lunel, Joseph R. Albe, Emily Cottle, Matthew D. Dunn, L. James Frye, Theron H. Gilliland, Emily L. Olsen, Katherine J. O'Malley, Madeline M. Schwarz, Jaime A. Tomko, Reagan C. Walker, Mengying Xia, Matthew S. Hartman, Edwin Klein, Charles A. Scanga, JoAnne L. Flynn, William B. Klimstra, Anita K. McElroy, Douglas S. Reed, W. Paul Duprex
Article
Infectious Diseases
Sarah Kim, Arnold Louie, George L. Drusano, Mohammed Almoslem, Soyoung Kim, Jenny Myrick, Jocelyn Nole, Brandon Duncanson, Charles A. Peloquin, Charles A. Scanga, Walter Yamada, Michael Neely, Stephan Schmidt
Summary: This study evaluated the efficacy of clofazimine (CFZ)-containing two-drug regimens with pretomanid (PMD), bedaquiline (BDQ), or linezolid (LZD) for the treatment of tuberculosis. The results showed synergistic effects when CFZ was combined with PMD, BDQ, and LZD against Mycobacterium tuberculosis in different metabolic states. The combination regimens demonstrated greater bacterial kill than the individual drugs. CFZ alone had the weakest antimicrobial efficacy among the evaluated drugs, and the correlation between the mode of interaction and the extent of bacterial kill was not significant.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Meeting Abstract
Veterinary Sciences
Erica Larson, Mark Rodgers, Amy Ellis, Cassaundra Ameel, Tonilynn Baranowski, Alexis Balgeman, Pauline Maiello, Shelby O'Connor, Charles Scanga
JOURNAL OF MEDICAL PRIMATOLOGY
(2019)
Meeting Abstract
Immunology
Joseph John Zeppa, Patricia A. Darrah, Supriya Pokkali, Joshua A. Hackney, Pauline A. Maiello, Charles A. Scanga, Dominick J. Laddy, Philiana Ling Lin, Robert A. Seder, Mario Roederer, JoAnne L. Flynn
JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
Nicole L. Grant, Alexis J. Balgeman, Amy L. Ellis, Shelby L. O'Connor, Charles A. Scanga, JoAnne L. Flynn
JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Veterinary Sciences
Mark Rodgers, Cassaundra Updike, Amy Ellis, Alexis Balgeman, Pauline Maiello, Tom Friedrich, Gabrielle Barry, Joshua Mattila, Shelby O'Connor, Charles A. Scanga
JOURNAL OF MEDICAL PRIMATOLOGY
(2018)
Meeting Abstract
Veterinary Sciences
Alexis Balgeman, Amy Ellis-Connell, Katie Zarbock, Jaffna Mathiaparanam, Mark A. Rodgers, Cassandra Updike, Tonilynn Baranowski, Charles A. Scanga, Shelby O'Connor
JOURNAL OF MEDICAL PRIMATOLOGY
(2018)
Article
Immunology
Pauline Maiello, Robert M. DiFazio, Anthony M. Cadena, Mark A. Rodgers, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
INFECTION AND IMMUNITY
(2018)