Article
Multidisciplinary Sciences
Yukihiro Wada, Masayuki Iyoda, Kei Matsumoto, Taihei Suzuki, Shohei Tachibana, Nobuhiro Kanazawa, Hirokazu Honda
Summary: Inhibition of IL-34 can alleviate cisplatin-induced damage to renal tubular epithelial cells, improve renal function, reduce intrarenal cell apoptosis and macrophage infiltration, and have a protective effect against cisplatin nephrotoxicity. Blocking IL-34 may be a potential therapeutic target for renal tubular epithelial cell injury.
Article
Immunology
Iman O. Sherif, Nora H. Al-Shaalan
Summary: The study demonstrated that vildagliptin could significantly alleviate lung injury caused by hepatic ischemia/reperfusion by suppressing oxidative stress, inflammation, and related gene expressions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Dou Huang, Changwei Chen, Yunxia Zuo, Lei Du, Ting Liu, Geoffrey W. Abbott, Zhaoyang Hu
Summary: This study found that RLIPost reduces pulmonary damage induced by ischemia-reperfusion in both non-diabetic and diabetic rats. The protective mechanism in non-diabetic rats is associated with STAT-3, while in diabetic rats it is independent of STAT-3.
Article
Reproductive Biology
Vahid Ganjiani, Nasrollah Ahmadi, Mohammad Reza Divar, Hassan Sharifiyazdi, Abdolhamid Meimandi-Parizi
Summary: The study revealed that I/R injury significantly affects sperm parameters, but crocin treatment did not significantly improve them. Crocin significantly improved histopathological parameters and hormone levels, reversing oxidative stress injuries caused by torsion/detorsion.
Article
Pharmacology & Pharmacy
Jiajia Li, Yupeng Jiang, Qin Dai, Yue Yu, Xin Lv, Yan Zhang, Xiaohua Liao, Liyun Ao, Gaoyun Hu, Jie Meng, Zhangzhe Peng, Lijian Tao, Yanyun Xie
Summary: In this study, the protective effect of Mefunidone on ischemia-reperfusion injury-induced acute kidney injury was investigated. The results showed that Mefunidone can protect the kidney by relieving kidney tubular injury, suppressing oxidative stress, and inhibiting cell apoptosis. Furthermore, Mefunidone reduced mitochondrial damage and protected mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing Mu, Chunxiao Li, Shi Yu, Guoyong Liu, Jianhua Zou, Dong-Yang Zhang, Chao Jiang, Xiuli Wang, Liangcan He, Peng Huang, Yuxin Yin, Xiaoyuan Chen
Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Mei Li, Zhi Zheng
Summary: Parecoxib sodium attenuates intestinal injury induced by ischemia reperfusion by increasing antioxidant levels, suppressing oxidative damage, reducing inflammation, and promoting cell survival. It also improves the survival rate of rats post-reperfusion by inhibiting apoptosis and inflammation caused by I/R.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Ling Zhou, Xinlu Yang, Shuhua Shu, Sheng Wang, Fenglin Guo, Ying Yin, Weide Zhou, Han Han, Xiaoqing Chai
Summary: The study demonstrated that sufentanil exerts a significant protective effect against liver I/R injury by inhibiting inflammatory factors and reducing hepatocyte apoptosis. TP53BP2 is a key target for sufentanil in protecting the liver, with ATF4 potentially influencing sufentanil's protective effects by regulating TP53BP2 expression.
Article
Medicine, Research & Experimental
Zexin Li, Ying Wang, Yu Zhang, Xiao Wang, Baoqin Gao, Yan Li, Rong Li, Jianguo Wang
Summary: Fisetin was found to alleviate liver damage, cell apoptosis, and oxidative stress induced by liver IRI, at least through the Nrf2/HO-1 signaling pathway, suggesting its potential as a targeted drug for liver IRI treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mathias Clarysse, Alison Accarie, Ricard Farre, Emilio Canovai, Diethard Monbaliu, Jan Gunst, Gert De Hertogh, Tim Vanuytsel, Jacques Pirenne, Laurens J. J. Ceulemans
Summary: Animal research on intestinal ischemia-reperfusion injury (IRI) is mainly done using rodent models. Previously, intraperitoneal injections with ketamine-xylazine mixtures were common, but now volatile anesthetics like isoflurane are more commonly used. However, the impact of the anesthetic method on intestinal IRI has not been studied. This study aims to analyze the different anesthetic methods and their influence on the extent of intestinal IRI in a rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Binghui Jin, Guangyao Li, Lin Zhou, Zhe Fan
Summary: This paper outlines the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Xiangyu Xu, Yu Cui, Congqin Li, Yuyang Wang, Jing Cheng, Songfeng Chen, Jiangdong Sun, Jinyang Ren, Xujin Yao, Jingchen Gao, Xiaohong Huang, Qi Wan, Qiang Wang
Summary: The protein level of SETD3 decreases in neurons after cerebral ischemia-reperfusion (I/R) injury, while SETD3 promotes neuronal survival. Further research shows that I/R-induced upregulation of PTEN leads to the downregulation of SETD3, mediating ischemic neuronal death through suppression of actin polymerization.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hanzhang Teng, Liping Zhou, Cuicui Wang, Zhixin Yuan, Qilong Cao, Xianggen Wu, Mengshuang Li
Summary: This study developed a novel CAR pro-phytomicelles nanoformulation which significantly increased the solubility of CAR in water, exhibited good storage stability, rapid in vitro release, improved antioxidant activity, and good biocompatibility. It also showed significant protective effects against acetaminophen overdose-induced liver injury.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Gastroenterology & Hepatology
Hanno Ehlken, Rudiger Schmitz, Sabine Riethdorf, Lutz Riethdorf, Jenny Krause, Karl-Frederick Karstens, Jorg Schrader, Fabrice Viol, Anastasios Giannou, William Sterlacci, Michael Vieth, Till Clauditz, Christian Kaehler, Oliver Mann, Jakob R. Izbicki, Samuel Huber, Klaus Pantel, Thomas Roesch
Summary: This study analyzed the potential cause of local recurrence after curative endoscopic therapy for superficial Barrett carcinoma, finding that contaminated endoscopes and accessories may lead to tumor cell reimplantation, and corticosteroid injection could also promote tumor regrowth.
Article
Medicine, General & Internal
Michael Vogel, Hanno Ehlken, Stefan Kluge, Thomas Roesch, Ansgar W. Lohse, Samuel Huber, Martina Sterneck, Peter Huebener
Summary: Concomitant cirrhosis in patients with acute pancreatitis increases the risk for infections, periprocedural complications, multiorgan failure, and death.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Immunology
Thomas Theo Brehm, Felix Ullrich, Michelle Thompson, Julia Kuechen, Dorothee Schwinge, Anthea Spier, Samuel Huber, Johannes K. Knobloch, Martin Aepfelbacher, Marylyn M. Addo, Ansgar W. Lohse, Marc Luetgehetmann, Julian Schulze zur Wiesch
Summary: This study indicates that three exposures to the viral spike protein through either SARS-CoV-2 infection or COVID-19 vaccination are necessary to elicit particularly strong humoral immune responses.
Article
Gastroenterology & Hepatology
Timur Liwinski, Sina Huebener, Lara Henze, Peter Huebener, Melina Heinemann, Marcus Tetzlaff, Marie Hiller, Bettina Jagemann, Rambabu Surabattula, Diana Leeming, Morten Karsdal, Erika Monguzzi, Guido Schachschal, Thomas Roesch, Corinna Bang, Andre Franke, Ansgar W. Lohse, Detlef Schuppan, Christoph Schramm
Summary: This study suggests that a short-term gluten/ATI-free diet may not lead to clinical improvement in patients with PSC-IBD, but it can improve biomarkers of intestinal inflammation and barrier function, as well as affect changes in the enteric microbiota.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Monica T. Jimenez, Megan L. Clark, Jasmine M. Wright, Michael F. Michieletto, Suying Liu, Isabel Erickson, Lenka Dohnalova, Giulia T. Uhr, John Tello-Cajiao, Leonel Joannas, Adam Williams, Nicola Gagliani, Meenakshi Bewtra, Vesselin T. Tomov, Christoph A. Thaiss, Jorge Henao-Mejia
Summary: The miR-181 family is downregulated in IECs from human IBD patients and in mice with colitis. It promotes IEC proliferation and re-epithelialization by enhancing Wnt signaling. The expression of miR-181 in IECs is crucial for protecting mice from severe colonic inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Anastasios D. Giannou, Jan Kempski, Ahmad Mustafa Shiri, Joran Luecke, Tao Zhang, Lilan Zhao, Dimitra E. Zazara, Filippo Cortesi, Kristoffer Riecken, Maria Carolina Amezcua Vesely, Jun Siong Low, Hao Xu, Eleanna Kaffe, Laura Garcia-Perez, Theodora Agalioti, Yoshito Yamada, Wolfgang Jungraithmayr, Ehud Zigmond, Karl-Frederick Karstens, Babett Steglich, Jonas Wagner, Leonie Konczalla, Antonella Carambia, Kornelius Schulze, Johann von Felden, Peter May, Daria Briukhovetska, Tanja Bedke, Leonie Brockmann, Sarah Starzonek, Tobias Lange, Claudia Koch, Sabine Riethdorf, Penelope Pelczar, Marius Boettcher, Morsal Sabihi, Francis J. Huber, Matthias Reeh, Julia Kristin Grass, Ramez Wahib, Hannes Seese, Bjorn-Ole Stueben, Mohammad Fard-Aghaie, Anna Dupree, Pasquale Scognamiglio, Gabriel Plitzko, Jan Meiners, Shiwa Soukou, Agnes Wittek, Caroline Manthey, Ioannis C. Maroulis, Petra C. Arck, Daniel Perez, Bin Gao, Sotirios G. Zarogiannis, Till Strowig, Renata Pasqualini, Wadih Arap, Javier Suarez Gosalvez, Sebastian Kobold, Immo Prinz, Andreas H. Guse, Michael Tachezy, Tarik Ghadban, Asmus Heumann, Jun Li, Nathaniel Melling, Oliver Mann, Jakob R. Izbicki, Klaus Pantel, Udo Schumacher, Ansgar W. Lohse, Richard A. Flavell, Nicola Gagliani, Samuel Huber
Summary: During metastasis, cancer cells go through a series of steps including invasion, intravasation, circulation, extravasation, and colonization of target organs. This study investigated the role of interleukin (IL)-22 in metastasis and found that IL-22 promotes metastasis through its action on endothelial cells and induction of endothelial aminopeptidase N. IL-22-producing iNKT cells were identified as a source of IL-22 and were shown to be tissue resident. Thus, IL-22 may be a potential therapeutic target for preventing metastasis.
Article
Oncology
Anastasios D. Giannou, Joran Luecke, Dorte Kleinschmidt, Ahmad Mustafa Shiri, Babett Steglich, Mikolaj Nawrocki, Tao Zhang, Dimitra E. Zazara, Jan Kempski, Lilan Zhao, Olympia Giannou, Theodora Agalioti, Leonie Brockmann, Franziska Bertram, Morsal Sabihi, Marius Boettcher, Florian Ewald, Kornelius Schulze, Johann von Felden, Andres Machicote, Ioannis C. Maroulis, Petra C. Arck, Julia-Kristin Grass, Baris Mercanoglu, Matthias Reeh, Stefan Wolter, Michael Tachezy, Hannes Seese, Myrto Theodorakopoulou, Panagis M. Lykoudis, Asmus Heumann, Faik G. Uzunoglu, Tarik Ghadban, Oliver Mann, Jakob R. Izbicki, Jun Li, Anna Dupree, Nathaniel Melling, Nicola Gagliani, Samuel Huber
Summary: The study aimed to investigate the role and mechanisms of IL-22 and IL-22BP signaling in liver cancer. The results showed that IL-22 promoted HCC development, while IL-22BP reduced tumor growth. IL-22 was mainly produced by a subset of T cells in HCC, while IL-22BP was abundantly secreted by neutrophils. Hepatocytes were identified as a major target of this pathological IL-22 signaling.
Article
Medicine, Research & Experimental
Anna Woestemeier, Pasquale Scognamiglio, Yu Zhao, Jonas Wagner, Franziska Muscate, Christian Casar, Francesco Siracusa, Filippo Cortesi, Theodora Agalioti, Simone Mueller, Adrian Sagebiel, Leonie Konczalla, Ramez Wahib, Karl-Frederick Karstens, Anastasios D. Giannou, Anna Dupree, Stefan Wolter, Milagros N. Wong, Anne K. Muhlig, Agata A. Bielecka, Vikas Bansal, Tianran Zhang, Oliver Mann, Victor G. Puelles, Tobias B. Huber, Ansgar W. Lohse, Jakob R. Izbicki, Noah W. Palm, Stefan Bonn, Samuel Huber, Nicola Gagliani
Summary: This study reveals the role of CD4(+) T cells with a Th17 polarization state in the progression of nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) and the development of fibrosis. The study also suggests a potential contribution of the gut-liver axis in NASH, with Bacteroides enrichment in the intestine correlating with the frequency of multicytokine-producing CD4(+) T cells.
Correction
Multidisciplinary Sciences
Zheng Wei, Joonseok Oh, Richard A. Flavell, Jason M. Crawford
Article
Biochemistry & Molecular Biology
Mariella Weiss, Lola C. Hernandez, Diana Gil C. Montoya, Anke Loehndorf, Aileen Krueger, Miriam Kopdag, Liana Uebler, Marie Landwehr, Mikolaj Nawrocki, Samuel Huber, Lena-Marie Woelk, Rene Werner, Antonio V. Failla, Alexander Fluegel, Genevieve Dupont, Andreas H. Guse, Bjoern-Philipp Diercks
Summary: During immune response, T cells migrate into inflamed tissues by moving across the endothelium and extracellular matrix. Integrins facilitate T cell binding to endothelial cells and extracellular matrix proteins. Adhesion to ECM proteins triggers Ca2+ microdomains formation, increasing the sensitivity of T cells to activation.
Article
Gastroenterology & Hepatology
Agnes Wittek, Babett Steglich, Christian Casar, Oliver Seiz, Philipp Huber, Hanno Ehlken, Dominik Reher, Sandra Wende, Tanja Bedke, Jan Kempski, Marius Boettcher, Corinna Bang, Louise Thingholm, Till Krech, Ansgar W. Lohse, Guido Sauter, Thomas Roesch, Andre Franke, Christoph Schramm, Nicola Gagliani, Penelope Pelczar, Samuel Huber
Summary: It is found that patients with primary sclerosing cholangitis (PSC) have a gradient of intestinal inflammation, even in the absence of clinically manifest inflammatory bowel disease (IBD). This has implications for their therapy and the surveillance of colorectal cancer.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Colton Ladbury, Richard Li, Anseh Danesharasteh, Zeynep Ertem, Andrew Tam, Jason Liu, Claire Hao, Rose Li, Heather McGee, Sagus Sampath, Terence Williams, Scott Glaser, Mohammad Khasawneh, Zhongxing Liao, Percy Lee, Jeff Ryckman, Parvez Shaikh, Arya Amini
Summary: This study used machine learning and explainable artificial intelligence to analyze the dosimetric predictors of toxicity in patients treated as part of a prospective clinical trial and identified relevant dosimetric thresholds.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Gastroenterology & Hepatology
Vincent Joerg, Bernhard Scheiner, Antonio D'Alessio, Claudia A. M. Fulgenzi, Martin Schoenlein, Lorenz Kocheise, Ansgar W. Lohse, Samuel Huber, Henning Wege, Ahmed Kaseb, Yinghong Wang, Antony Mathew, Andrew Kuang, Mahvish Muzaffar, Yehia I. Abugabal, Shadi Chamseddine, Samuel Phen, Jaekyung Cheon, Pei-Chang Lee, Lorenz Balcar, Anja Krall, Celina Ang, Linda Wu, Anwaar Saeed, Yi-Hsiang Huang, Bertram Bengsch, Lorenza Rimassa, Arndt Weinmann, Rudolf Stauber, James Korolewicz, Matthias Pinter, Amit G. Singal, Hong Jae Chon, David J. Pinato, Kornelius Schulze, Johann von Felden
Summary: This study found that the combination treatment of atezolizumab and bevacizumab showed good efficacy and safety in patients with HCC who had previously received systemic therapy.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Cell Biology
Chenbo Ding, Zhibin Yu, Esen Sefik, Jing Zhou, Eleanna Kaffe, Gaoyang Wang, Bin Li, Richard A. Flavell, Weiguo Hu, Youqiong Ye, Hua-Bing Li
Summary: This study identified a T-reg-specific long noncoding RNA called Altre, which plays a role in regulating the mitochondrial function of T-reg cells in the liver of old mice by binding to Yin Yang 1. Deletion of Altre accelerates aging-associated liver pathogenesis.
Article
Multidisciplinary Sciences
Jana H. Badrani, Allyssa N. Strohm, Lee Lacasa, Blake Civello, Kellen Cavagnero, Yung-An Haung, Michael Amadeo, Luay H. Naji, Sean J. Lund, Anthea Leng, Hyojoung Kim, Rachel E. Baum, Naseem Khorram, Monalisa Mondal, Gregory Seumois, Julie Pilotte, Peter W. Vanderklish, Heather M. McGee, Taylor A. Doherty
Summary: This study found that RNA-binding motif 3 (RBM3) is highly expressed in lung innate lymphoid cells (ILCs) and is induced by alarmins TSLP and IL-33. Mice lacking RBM3 exposed to asthma-associated allergens develop enhanced eosinophilic lung inflammation and ILC activation. RBM3 suppresses ILC responses and its absence leads to increased ILC cytokine production. The study also identified the cysteinyl leukotriene 1 receptor (CysLT1R) as a key factor in RBM3-mediated regulation of ILCs during allergen-induced type 2 inflammation.
NATURE COMMUNICATIONS
(2022)