Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

(2017) Simon A. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COLEC10 is mutated in 3MC patients and regulates early craniofacial development

(2017) Mustafa M. Munye et al.   PLoS Genetics

Exploring the genetic basis of 3MC syndrome: Findings in 12 further families

(2016) Jill Urquhart et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2016) Xuan Yuan et al.   HAEMATOLOGICA

Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing

(2016) Nirmal K. Banda et al.   JOURNAL OF IMMUNOLOGY

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation

(2016) No-Joon Song et al.   PLoS One

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors

(2016) Chao-Yie Yang et al.   ACS Medicinal Chemistry Letters

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2016) Xuan Yuan et al.   HAEMATOLOGICA

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked

(2016) József Dobó et al.   Scientific Reports

MASP-1 and MASP-2 Do Not Activate Pro–Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors

(2015) Gábor Oroszlán et al.   JOURNAL OF IMMUNOLOGY

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Novel MASP1 mutations are associated with an expanded phenotype in 3MC1 syndrome

(2015) Tahir Atik et al.   Orphanet Journal of Rare Diseases

Structural Insights into the Initiating Complex of the Lectin Pathway of Complement Activation

(2015) Troels R. Kjaer et al.   STRUCTURE

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

(2014) James C. Lo et al.   CELL

Comment on "The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function"

(2014) M. Takahashi et al.   JOURNAL OF IMMUNOLOGY

The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function

(2014) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

(2014) Søren E. Degn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants

(2013) Tanis R Fenton et al.   BMC Pediatrics

C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independentin vivo

(2013) M. M. Ruseva et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

(2013) Tang Yongqing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

(2013) Márton Megyeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Adipocytes and Fibroblasts in Activation of the Alternative Pathway of Complement in Inflammatory Arthritis in Mice

(2013) W. P. Arend et al.   JOURNAL OF IMMUNOLOGY

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

(2012) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway

(2011) D. Iwaki et al.   JOURNAL OF IMMUNOLOGY

Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome

(2011) Caroline Rooryck et al.   NATURE GENETICS

MASP1 Mutations in Patients with Facial, Umbilical, Coccygeal, and Auditory Findings of Carnevale, Malpuech, OSA, and Michels Syndromes

(2010) Asli Sirmaci et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The lectin pathway and its implications in coagulation, infections and auto-immunity

(2010) Søren E Degn et al.   Current Opinion in Organ Transplantation

Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system

(2010) Søren E. Degn et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Complement factor D, a novel serine protease

(2010) John E. Volanakis et al.   PROTEIN SCIENCE

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

(2009) Minoru Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS