PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism

Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis inDrosophila melanogaster

(2016) Emiliana Tognon et al.   Autophagy

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

(2016) Sunmin Park et al.   Cell Host & Microbe

Human Xenobiotic Nuclear Receptor PXR AugmentsMycobacterium tuberculosisSurvival

(2016) Ella Bhagyaraj et al.   JOURNAL OF IMMUNOLOGY

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

(2016) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

(2016) Mireille Ouimet et al.   NATURE IMMUNOLOGY

NR1D1 amelioratesMycobacterium tuberculosisclearance through regulation of autophagy

(2015) Vemika Chandra et al.   Autophagy

Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice

(2015) Federico Penas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation

(2015) Jae-Min Yuk et al.   IMMUNITY

Activation of Peroxisome Proliferator-activated Receptor α Induces Lysosomal Biogenesis in Brain Cells

(2015) Arunava Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engagement of the Aryl Hydrocarbon Receptor inMycobacterium tuberculosis–Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling

(2015) Babak Memari et al.   JOURNAL OF IMMUNOLOGY

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

(2015) S. Okada et al.   SCIENCE

Therapeutic Effects of PPARαon Neuronal Death and Microvascular Impairment

(2015) Elizabeth P. Moran et al.   PPAR Research

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway

(2014) M Jiao et al.   Cell Death & Disease

Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility

(2014) Guoliang Zhang et al.   PLoS Pathogens

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Exploitation of host lipids by bacteria

(2013) François Vromman et al.   CURRENT OPINION IN MICROBIOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype

(2012) Varshneya Singh et al.   Cell Host & Microbe

Failure To Recruit Anti-Inflammatory CD103+Dendritic Cells and a Diminished CD4+Foxp3+Regulatory T Cell Pool in Mice That Display Excessive Lung Inflammation and Increased Susceptibility to Mycobacterium tuberculosis

(2012) Chaniya Leepiyasakulchai et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPAR  and TR4 for Survival

(2012) S. Mahajan et al.   JOURNAL OF IMMUNOLOGY

The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases

(2012) Je-Min Choi et al.   MOLECULES AND CELLS

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

(2011) Sandrine Dubrac et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

(2011) Kari A Sweeney et al.   NATURE MEDICINE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1

(2010) H.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

Dissection of Rab7 localization on Mycobacterium tuberculosis phagosome

(2009) Shintaro Seto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

Mycobacterium bovis Bacillus Calmette-Guerin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor   Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis

(2009) P. E. Almeida et al.   JOURNAL OF IMMUNOLOGY

Dominant‐Negative Tumor Necrosis Factor Protects fromMycobacterium bovisBacillus Calmette‐Guérin (BCG) and Endotoxin‐Induced Liver Injury without Compromising Host Immunity to BCG andMycobacterium tuberculosis

(2009) Maria L. Olleros et al.   JOURNAL OF INFECTIOUS DISEASES

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens