Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

Molecular basis of ion permeability in a voltage‐gated sodium channel

(2016) Claire E Naylor et al.   EMBO JOURNAL

Modeling interactions between blocking and permeant cations in the NavMs channel

(2016) Vyacheslav S. Korkosh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels

(2014) Denis B. Tikhonov et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

(2014) C. Boiteux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

(2014) C. Bagneris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

Ligand action on sodium, potassium, and calcium channels: role of permeant ions

(2013) Boris S. Zhorov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Voltage-gated sodium channels at 60: structure, function and pathophysiology

(2012) William A. Catterall   JOURNAL OF PHYSIOLOGY-LONDON

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Bisphenol A Binds to the Local Anesthetic Receptor Site to Block the Human Cardiac Sodium Channel

(2012) Andrias O. O’Reilly et al.   PLoS One

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel

(2012) Yang Yang et al.   Nature Communications

The Enigmatic Drug Binding Site for Sodium Channel Inhibitors

(2012) Arpad Mike et al.   Current Molecular Pharmacology

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels

(2011) Stephan A. Pless et al.   Nature Communications

Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function

(2010) Daniel P. Garden et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

(2010) G. M. Lipkind et al.   MOLECULAR PHARMACOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Determinants of Drugs Acting on the Nav1.8 Channel

(2009) Liam E. Browne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding

(2009) T. Yamagishi et al.   MOLECULAR PHARMACOLOGY

Access and Binding of Local Anesthetics in the Closed Sodium Channel

(2008) I. Bruhova et al.   MOLECULAR PHARMACOLOGY

Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels

(2007) Christopher A. Ahern et al.   CIRCULATION RESEARCH