Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca 2+

FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2

(2016) J. Z. Zhang et al.   BIOCHEMICAL JOURNAL

Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release

(2016) Helen M.M. Waddell et al.   BIOPHYSICAL JOURNAL

Structural Basis for Gating and Activation of RyR1

(2016) Amédée des Georges et al.   CELL

Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1

(2016) Risheng Wei et al.   CELL RESEARCH

The Cytoplasmic Region of Inner Helix S6 Is an Important Determinant of Cardiac Ryanodine Receptor Channel Gating

(2016) Bo Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

(2016) Wei Peng et al.   SCIENCE

The EF-hand Ca2+Binding Domain Is Not Required for Cytosolic Ca2+Activation of the Cardiac Ryanodine Receptor

(2015) Wenting Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

(2015) Tetsuro Oda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

(2015) Yan-Ting Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cardiac ryanodine receptor luminal Ca2+sensor governs Ca2+waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice

(2014) Jingqun Zhang et al.   BIOCHEMICAL JOURNAL

Cardiac ryanodine receptor activation by a high Ca 2+ store load is reversed in a reducing cytoplasmic redox environment

(2014) Amy D. Hanna et al.   JOURNAL OF CELL SCIENCE

The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+

(2014) Joe Z. Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+release

(2013) Xixi Tian et al.   BIOCHEMICAL JOURNAL

S4153R Is a Gain-of-Function Mutation in the Cardiac Ca2+ Release Channel Ryanodine Receptor Associated With Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation

(2013) Pavel Zhabyeyev et al.   CANADIAN JOURNAL OF CARDIOLOGY

Abnormal Termination of Ca 2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

(2012) Yijun Tang et al.   CIRCULATION RESEARCH

Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output

(2012) Angela F Dulhunty et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating

(2012) Horia Vais et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

(2010) Tao Guo et al.   CIRCULATION RESEARCH

Cardiac calsequestrin: quest inside the SR

(2010) Sandor Györke et al.   JOURNAL OF PHYSIOLOGY-LONDON

Changes in Negative Charge at the Luminal Mouth of the Pore Alter Ion Handling and Gating in the Cardiac Ryanodine-Receptor

(2009) Fiona C. Mead-Savery et al.   BIOPHYSICAL JOURNAL

Flux regulation of cardiac ryanodine receptor channels

(2009) Yiwei Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes

(2008) Sabine Huke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Caffeine induces Ca2+release by reducing the threshold for luminal Ca2+activation of the ryanodine receptor

(2008) Huihui Kong et al.   BIOCHEMICAL JOURNAL

Reduced Threshold for Luminal Ca2+Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

(2008) Dawei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY