Abnormal Termination of Ca 2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

Dynamic local changes in sarcoplasmic reticulum calcium: Physiological and pathophysiological roles

(2011) Eric A. Sobie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by β Strand Switching

(2011) Paolo A. Lobo et al.   STRUCTURE

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation

(2010) Simon Sedej et al.   CARDIOVASCULAR RESEARCH

Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia

(2010) Dawei Jiang et al.   Channels

Ca 2+ /Calmodulin-Dependent Kinase IIδ Causes Heart Failure by Accumulation of p53 in Dilated Cardiomyopathy

(2010) Haruhiro Toko et al.   CIRCULATION

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

(2010) Hitoshi Uchinoumi et al.   CIRCULATION RESEARCH

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility

(2010) Sabine Huke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

(2010) Ching-Chieh Tung et al.   NATURE

Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia

(2009) Annukka Marjamaa et al.   BMC Medical Genetics

Alteration of sarcoplasmic reticulum Ca2+release termination by ryanodine receptor sensitization and in heart failure

(2009) Timothy L. Domeier et al.   JOURNAL OF PHYSIOLOGY-LONDON

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome

(2009) Argelia Medeiros-Domingo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Crystal structure of type I ryanodine receptor amino-terminal  -trefoil domain reveals a disease-associated mutation "hot spot" loop

(2009) F. J. Amador et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations

(2009) Paolo Antonio Lobo et al.   STRUCTURE

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

(2009) Montserrat Samsó et al.   PLOS BIOLOGY

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Termination of Cardiac Ca 2+ Sparks

(2008) Aleksey V. Zima et al.   CIRCULATION RESEARCH

Increased Ca 2+ Sensitivity of the Ryanodine Receptor Mutant RyR2 R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia

(2008) María Fernández-Velasco et al.   CIRCULATION RESEARCH

Mitochondrial Regulation of Sarcoplasmic Reticulum Ca 2+ Content in Vascular Smooth Muscle Cells

(2008) Damon Poburko et al.   CIRCULATION RESEARCH

Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?

(2008) S. R. Houser et al.   Science Signaling