Article
Endocrinology & Metabolism
Dimitrios A. Koutoukidis, Ferenc E. Mozes, Susan A. Jebb, Jeremy W. Tomlinson, Michael Pavlides, Francesca Saffioti, Rosemary Huntriss, Paul Aveyard, Jeremy F. Cobbold
Summary: The study demonstrates that a low-energy diet is a highly adherent, safe, and effective treatment for nonalcoholic steatohepatitis (NASH).
Article
Medicine, General & Internal
Jean-Eric Tarride, Aristithes G. Doumouras, Dennis Hong, J. Michael Paterson, Semra Tibebu, Francis Nguyen, Richard Perez, Valerie H. Taylor, Feng Xie, Vanessa Boudreau, Eleanor Pullenayegum, David R. Urbach, Mehran Anvari
Summary: This study compared 4-year health care expenditures after RYGB and sleeve gastrectomy, finding no significant differences in all-cause mortality and number of hospital admissions between the two procedures, but more frequent nonelective hospitalizations with RYGB. Patients who underwent RYGB had a lower rate of subsequent bariatric procedures.
Article
Multidisciplinary Sciences
Martin Aasbrenn, Mathilde Svendstrup, Theresia M. Schnurr, Dorte Lindqvist Hansen, Dorte Worm, Marie Balslev-Harder, Niels Grarup, Kristoffer Solvsten Burgdorf, Henrik Vestergaard, Oluf Pedersen, Larsa Angquist, Mogens Fenger, Thorkild I. A. Sorensen, Sten Madsbad, Torben Hansen
Summary: The study found that genetic risk scores for adiposity and the rs1358980-T risk allele were not predictive of weight loss after gastric bypass surgery. The association between a genetic risk score for abdominal obesity and response to bariatric surgery may depend on the baseline BMI.
Review
Endocrinology & Metabolism
Rutger J. Franken, Josephine Franken, Nina R. Sluiter, Ralph de Vries, Sjoerd Euser, Victor E. A. Gerdes, Maurits de Brauw
Summary: A systematic review and meta-analysis were conducted to evaluate various revisional techniques for addressing weight regain and inadequate weight loss after Roux-en-Y gastric bypass. The results showed that endoscopic procedures resulted in short-term weight loss, while surgical revision techniques were more successful in achieving long-term weight loss, albeit with higher complication rates.
Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Surgery
Tien-Chou Soong, Ming-Hsien Lee, Wei-Jei Lee, Jung-Chien Chen, Chun-Chi Wu, Shu-Chun Chun
Summary: One anastomosis gastric bypass (OAGB) is highly effective in inducing T2DM remission, but there is still a significant number of patients who may experience T2DM recurrence. Selecting patients with an ABCD score of 5 and maintaining a weight loss greater than 30% is crucial for durable T2DM remission after OAGB.
Review
Surgery
Pirjo Kakela, Tuomo Rantanen, Kirsi A. Virtanen
Summary: The narrative review discusses the potential optimization of outcomes in laparoscopic Roux-en-Y gastric bypass surgery by modifying the length of bypassed small intestine based on total small intestinal length. Due to the heterogeneity of included studies, the authors emphasize the importance of carefully selecting the excluded small intestine length for each individual patient to achieve efficient metabolic outcomes.
Review
Surgery
Mohammad Kermansaravi, Radwan Kassir, Rohollah Valizadeh, Chetan Parmar, Amir Hossein Davarpanah Jazi, Shahab Shahabi Shahmiri, Marine Benois
Summary: Complications like leaks after one-anastomosis gastric bypass (OAGB) should be managed properly, but there is limited data and no guidelines for leak management. A systematic review and meta-analysis of 46 studies involving 44,318 OAGB patients found a 1% prevalence of leaks. Surgical strategies varied, but about 62.1% of patients with leaks required additional surgery. The most common procedures for leak management were peritoneal washout and drainage, followed by conversion to Roux-en-Y gastric bypass. The mortality rate related to leaks was 1.95%.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Nutrition & Dietetics
Celine Drai, Andrea Chierici, Luigi Schiavo, Tagleb S. Mazahreh, Anne-Sophie Schneck, Antonio Iannelli
Summary: Pouch resizing after Roux-en-Y gastric bypass (RYGB) results in a failure rate of 47% at the 10-year follow-up, while the resolution of comorbidities is maintained over time despite significant weight regain.
Article
Endocrinology & Metabolism
C. Brent Wakefield, Vanessa R. Lee, Danielle Johnston, Parastoo Boroumand, Nicolas J. Pillon, Samar Sayedyahossein, Brooke L. O'Donnell, Justin Tang, Rafael E. Sanchez-Pupo, Kevin J. Barr, Robert Gros, Lauren Flynn, Nica M. Borradaile, Amira Klip, Frank Beier, Silvia Penuela
Summary: PANX3 expression in male adult mouse adipose tissue may regulate adipocyte numbers, influencing fat accumulation and inflammation. Male KO mice fed a chow diet had lower body weight and lower fat mass, reduced to the same extent as WT mice with forced exercise, suggesting a potential role of PANX3 in regulating body weight. Additionally, KO mice exhibited a more anti-inflammatory phenotype on a high-fat diet compared to WT mice, with significantly lower expression of multiple pro-inflammatory genes in white adipose tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Multidisciplinary Sciences
Chang Ho Ahn, Eun Hye Choi, Hyunjung Lee, Woochan Lee, Jong-Il Kim, Young Min Cho
Summary: VSG surgery can reduce body weight, improve glucose tolerance, and induce unique gene expression changes in the liver, fat, and muscle, but not more significantly than the pair-fed group of sham-operated mice. VSG surgery can induce organ-specific gene expression changes in the liver, fat, and muscle, which may play critical roles in metabolic improvements after VSG.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
H. J. M. Smelt, S. Van Rijn, S. Pouwels, M. P. W. Aarts, J. F. Smulders
Summary: A longer BPL (biliopancreatic limb) is associated with more %EWL and %TWL 2 years after RYGB. However, it is accompanied by an increase in diarrhea and steatorrhea. Future studies should focus on tailoring BPL and AL lengths for optimal outcomes in morbidly obese patients.
Article
Surgery
Catherine Tsai, Maria Dimou, Markus Naef, Rudolf Steffen, Jorg Zehetner, Christos T. Nakas, Lia Bally
Summary: This study compared the effect of banded and non-banded Roux-en-Y gastric bypass (RYGB) on weight loss over a 5-year follow-up period. The results showed that patients who underwent banded RYGB had a lower risk of insufficient weight loss compared to those who underwent non-banded RYGB. There were no differences in cardiometabolic outcomes between the two groups. Further research is needed to understand the effects of eating behavior restriction and neuroendocrine responses after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Eileen Roach, Simon Laplante, Shannon Stogryn, Azusa Maeda, Timothy Jackson, Allan Okrainec
Summary: The study aimed to determine the weight-loss outcomes of patients who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) after laparoscopic sleeve gastrectomy (LSG) and whether outcomes differed according to indications for conversion. The study found that patients who underwent LRYGB after previous LSG had a consistent weight-loss outcome regardless of the reason for conversion.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Editorial Material
Surgery
Lea Robin, Sebastien Gaujoux, Laurent Genser
ANZ JOURNAL OF SURGERY
(2023)
Article
Surgery
Alessandra D'Alessandro, Jean-Loup Dumont, Ibrahim Dagher, Francesco Zito, Giovanni Galasso, Hadrien Tranchart, Fabrizio Cereatti, Jean-Marc Catheline, Guillaume Pourcher, Lionel Rebibo, Daniela Calabrese, Simon Msika, Hugo Rotkopf, Thierry Tuszynski, Filippo Pacini, Roberto Arienzo, Antonio D'Alessandro, Adriana Torcivia, Laurent Genser, Konstantinos Arapis, Renaud Chiche, Giovanni Domenico De Palma, Mario Musella, Jean-Marc Chevallier, Gianfranco Donatelli
Summary: Gastric sleeve stenosis can be managed effectively through endoscopic treatment, with a success rate of 69%. The characteristics of the stenosis should guide the choice of endoscopic approach.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Levi-Dan Azoulay, Marine Bravetti, Fleur Cohen-Aubart, Jean-Francois Emile, Danielle Seilhean, Isabelle Plu, Frederic Charlotte, Xavier Waintraub, Fabrice Carrat, Zahir Amoura, Philippe Cluzel, Julien Haroche
Summary: This study investigated the prevalence and clinical features of cardiac involvement in Erdheim-Chester disease (ECD). It found that nearly half of the patients had cardiac involvement, which was associated with BRAFV600E mutation and complications (pericarditis, cardiac tamponade, and conduction disorders), but not with lower survival.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Flora Lambert, Sarah Chalopin, Dorothee Bedock, Cecile Ciangura, Judith Aron-Wisnewsky, Pauline Faucher, Laura Aviles Marquez, Rufin Louhou, Christine Poitou, Jean-Michel Oppert, Pierre Bel Lassen
Summary: This case report describes the difficulties in managing a 30-year-old woman with extreme obesity, who was unable to undergo adapted imaging due to her weight. The case highlights the importance for healthcare systems to adapt to the specific needs of these patients and to design specific guidelines for treatment.
Review
Endocrinology & Metabolism
Christine Poitou, Anthony Holland, Charlotte Hoybye, Laura C. G. de Graaff, Sandrine Bottius, Berit Otterlei, Maithe Tauber
Summary: Prader-Willi syndrome (PWS) is a common neurodevelopmental genetic disorder characterized by obesity, endocrine disorders, and psychiatric issues. The transition from adolescence to adulthood in individuals with PWS can be challenging due to multiple comorbidities and complex disabilities. Medical care for PWS individuals may be inadequate due to a lack of understanding of the syndrome and a lack of specialized skills.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Shanat Baig, Subadra Wanninayake, Lukas Foggensteiner, Yasir S. Elhassan, Konstantinos Manolopoulos, Sadaf Ali, Pierre Bel Lassen, Karine Clement, Richard P. Steeds, Jeremy W. Tomlinson, Tarekegn Geberhiwot
Summary: In this study, adipose tissue structure and function were investigated in patients with Bardet-Biedl syndrome (BBS) and obese controls. The results showed that insulin sensitivity and adipose tissue function in BBS patients were similar to those in polygenic obesity, suggesting that the quality and quantity of obesity rather than the duration play a more important role in driving the metabolic phenotype.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Letter
Oncology
Marine Armand, Michael Degaud, Bruno Tesson, Cecile Laurent, Manon Vavasseur, Melanie Parisot, Benedicte Hoareau-Coudert, Danielle Canioni, Jean Marie Michot, Frederic Charlotte, Veronique Meignin, Camille Laurent, Alexandra Traverse-Glehen, Diane Damotte, Emmanuel Bachy, Caroline Besson, Olivier Hermine, Frederic Davi, Lucile Couronne
Correction
Surgery
Ahmed Daouadji-Ghazouani, Judith Aron-Wisnewsky, Adriana Torcivia, Marc Irigoin-Guichandut, Christine Poitou, Pauline Faucher, Cecile Ciangura, Pierre Bel Lassen, Karine Clement, Jean-Christophe Vaillant, Jean-Michel Oppert, Laurent Genser
Article
Surgery
Ahmed Daouadji-Ghazouani, Judith Aron-Wisnewsky, Adriana Torcivia, Marc Irigoin-Guichandut, Christine Poitou, Pauline Faucher, Cecile Ciangura, Pierre Bel Lassen, Karine Clement, Jean-Christophe Vaillant, Jean-Michel Oppert, Laurent Genser
Summary: During the COVID-19 pandemic, teleclinics were used as a substitute for face-to-face outpatient clinics, allowing for effective follow-up of bariatric patients while saving time and ensuring patient safety.
Editorial Material
Medicine, General & Internal
Laurent Genser, Dominique Thabut, Judith Aron-Wisnewsky
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Blandine Gatta-Cherifi, Alexandre Laboye, Caroline Gronnier, Maud Monsaingeon-Henry, Sarah Meulebrouck, Morgane Baron, Francoise Bertin, Emilie Pupier, Sophie Cambos, Christine Poitou, Johanne Le Beyec-Le Bihan, Amelie Bonnefond
Summary: A new pathogenic mutation in the MRAP2 gene was identified in a patient with severe multifactorial obesity, confirming the metabolic phenotype in this monogenic form of obesity.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Surgery
Clement Destan, Clement Baratte, Adriana Torcivia, Christophe Brevart, Brice Malgras, Karine Clement, Christine Poitou, Jean-Michel Oppert, Judith Aron-Wisnewsky, Laurent Genser
Summary: This retrospective study found that revisional Roux-Y-gastric-bypass (R-RYGB) is a popular surgical option for weight-loss failure (WLF) or proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG). R-RYGB corrected reflux symptoms and achieved additional weight loss in patients with WLF, except those with a history of adjustable gastric banding (AGB) prior to SG.
Article
Surgery
Ella Serrano, Jean-Philippe Bastard, Laurence Trystram, Soraya Fellahi, Hedi A. Soula, Sophie Thenet, Jean-Michel Oppert, Karine Clement, Christine Poitou, Laurent Genser
Summary: Obesity is related to low-grade inflammation, and Roux-en-Y gastric bypass (RYGB) can improve obesity-related parameters. This study aimed to investigate the effects of RYGB on fecal and serum calprotectin (FC-SC) levels and their relationship with metabolic and inflammatory phenotypes.
Letter
Hematology
Levi-Dan Azoulay, Marine Bravetti, Fleur Cohen-Aubart, Jean-Francois Emile, Frederic Charlotte, Zahir Amoura, Philippe Cluzel, Julien Haroche