Article
Cell Biology
Zhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao, Peipei Jiang, Dan Liu, Zhiyin Wang, Haining Lv, Ruotian Li, Ying Hong, Jianwu Dai, Yali Hu, Guangfeng Zhao
Summary: Defective autophagy plays an important role in endometrial fibrosis by regulating EEC-EMT through the DIO2-MAPK/ERK-MTOR pathway.
Review
Biochemistry & Molecular Biology
Valeria Ramundo, Giada Zanirato, Elisabetta Aldieri
Summary: This review aims to describe how EMT is involved in driving the development and invasiveness of MPM, in an attempt to open new scenarios useful in the identification of predictive markers and improve the pharmacological approach against this aggressive cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Veterinary Sciences
Federico Armando, Federico Mazzola, Luca Ferrari, Attilio Corradi
Summary: This review discusses the general concept of epithelial-mesenchymal transition (EMT) and its regulation by various factors. It covers the role of transcription factors, microRNAs, reactive oxygen species, exosomes, microvesicles, and viruses in EMT. The review also examines EMT in embryonic development, fibrosis, and cancer metastasis, including discussions on the tumor microenvironment, pre-metastatic niches, and cancer stem cells. Additionally, it explores the use of EMT as a prognostic marker and provides insights into mesenchymal-epithelial transition (MET) in sarcomas. Therapeutic approaches for targeting EMT and MET are also addressed.
VETERINARY SCIENCES
(2023)
Article
Cell Biology
E. M. Olascoaga-Caso, E. Tamariz-Dominguez, J. C. Rodriguez-Alba, E. Juarez-Aguilar
Summary: In cancer, GH regulates EMT to promote metastasis, while in non-cancer cells, it does not affect EMT. GH might participate in cervical cancer progression by favoring a hybrid EMT phenotype.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Joris Vriens
Summary: EMT is a tightly regulated process essential for normal development but can also lead to fibrosis and cancer progression. Calcium is a key player in translating molecular messages during EMT, and calcium-permeable ion channels play a significant role in influencing cellular phenotype. TRP channels, as cellular sensors, are important proteins involved in decoding physical and chemical stimuli, making them ideal candidates to study in the context of phenotypic transitions like EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Joan Gil, Mireia Jorda, Berta Soldevila, Manel Puig-Domingo
Summary: Epithelial-mesenchymal transition is a dynamic process that plays essential roles in both physiological and pathological processes, particularly in the growth and invasion of pituitary tumors. Studies have shown the association of EMT with resistance to somatostatin receptor ligands in the treatment of acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemical Research Methods
Ayalur Raghu Subbalakshmi, Sarthak Sahoo, Prakruthi Manjunatha, Shaurya Goyal, Vignesh A. Kasiviswanathan, Yeshwanth Mahesh, Soundharya Ramu, Isabelle McMullen, Jason A. A. Somarelli, Mohit Kumar Jolly
Summary: ELF3 is a factor strongly associated with an epithelial phenotype and is inhibited during EMT. It inhibits the progression of EMT and can counteract EMT induction even in the presence of EMT-inducing factors. The prognostic capacity of ELF3 is specific to cell-of-origin or lineage.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ming-Yu Chou, Muh-Hwa Yang
Summary: The interplay between EMT and immune metabolic changes in cancer cells during tumor metastasis has gained interest among researchers. Understanding how they influence each other may provide novel explanations for immune surveillance during metastasis. Studying immunometabolism in the regulatory loop between tumor-infiltrating immune cells and EMT is crucial for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Stefano Zapperi, Caterina A. M. La Porta
Summary: Finding prognostic and predictive markers for TNBC is highly desirable, and the recently developed transcriptomic test ARIADNE shows promising capabilities in this regard.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Meredith S. Brown, Kristen E. Muller, Diwakar R. Pattabiraman
Summary: The epithelial-to-mesenchymal transition (EMT) and its reversal, the mesenchymal-to-epithelial transition (MET), play critical roles in the metastasis of breast cancer and other solid tumors. However, defining and quantifying EMT status is not commonly used in clinical practice. Therefore, identifying and measuring the presence of different EMT states in tumors is a crucial first step in evaluating patient prognosis.
Article
Oncology
Valerio Ciccone, Arianna Filippelli, Chiara Bacchella, Enrico Monzani, Lucia Morbidelli
Summary: This study investigates the antitumor effects of a novel nitric oxide (NO) donor, [Zn(PipNONO)Cl], on cancer cells and endothelial cells. The results demonstrate the potential therapeutic role of this NO donor in controlling tumor growth and metastasis by affecting epithelial-mesenchymal transition (EMT) and endothelial-mesenchymal transition (EndMT) processes.
Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jung-Yoon Heo, Jun-Young Do, Yunmee Lho, A-Young Kim, Sang-Woon Kim, Seok-Hui Kang
Summary: The study demonstrated that SB525334 effectively suppressed the epithelial-mesenchymal transition (EMT) induced by TGF-beta 1, reducing peritoneal fibrosis and thickness, and improving peritoneal membrane function in a peritoneal fibrosis mouse model.
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Edward O. List, Darlene E. Berryman, Reetobrata Basu, Mathew Buchman, Kevin Funk, Prateek Kulkarni, Silvana Duran-Ortiz, Yanrong Qian, Elizabeth A. Jensen, Jonathan A. Young, Gozde Yildirim, Shoshana Yakar, John J. Kopchick
Article
Endocrinology & Metabolism
Silvana Duran-Ortiz, Jonathan A. Young, Adam Jara, Elizabeth A. Jensen, Reetobrata Basu, Edward O. List, Yanrong Qian, John J. Kopchick, Darlene E. Berryman
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Chemistry, Medicinal
Dennis A. Roberts, Liyi Wang, Weihe Zhang, Yi Liu, Pratik Shriwas, Yanrong Qian, Xiaozhuo Chen, Stephen C. Bergmeier
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Endocrinology & Metabolism
Edward O. List, Reetobrata Basu, Silvana Duran-Ortiz, Jackson Krejsa, Elizabeth A. Jensen
Summary: GHD mouse lines exhibit negative characteristics such as delayed sexual maturation and decreased fertility, but they consistently outlive their normal sized littermates. The absence of GH action in these mouse lines leads to enhanced insulin sensitivity and delayed onset for age-associated physiological declines, ultimately extending lifespan.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Jonathan Young, Stephen Bell, Yanrong Qian, Caroline Hyman, Darlene E. Berryman
Summary: Growth hormone insensitivity (GHI) encompasses disorders where there is resistance to the action of GH and resulting IGF-I deficiency, often caused by genetic defects in GH receptor or post-receptor signaling molecules. Studying genetically altered mouse models has provided valuable insights into the physiological impact of GHI, revealing the role of GH in health, disease, and aging.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Silvana Duran-Ortiz, Edward O. List, Reetobrata Basu, John J. Kopchick
Summary: Progress in aging research has allowed exploration of interventions to slow aging and extend lifespan. Studies on yeast, worms, flies, and mice have revealed cellular and molecular mechanisms related to longevity, with sex-specific success in extending lifespan observed in adult mice. Targeting non-overlapping aging-related pathways with a combination of interventions appears to be an effective approach to extend healthy lifespan in both sexes.
Article
Oncology
Yanrong Qian, Reetobrata Basu, Samuel C. Mathes, Nathan A. Arnett, Silvana Duran-Ortiz, Kevin R. Funk, Alison L. Brittain, Prateek Kulkarni, Joseph C. Terry, Emily Davis, Jordyn T. Singerman, Brooke E. Henry, Edward O. List, Darlene E. Berryman, John J. Kopchick
Article
Cell Biology
Silvana Duran-Ortiz, Edward O. List, Yuji Ikeno, Jonathan Young, Reetobrata Basu, Stephen Bell, Todd McHugh, Kevin Funk, Samuel Mathes, Yanrong Qian, Prateek Kulkarni, Shoshana Yakar, Darlene E. Berryman, John J. Kopchick
Summary: Studies suggest that reducing growth hormone action can enhance healthy lifespan. In adult mice, disrupted GH action resulted in sexual dimorphic effects, with males showing enhanced insulin sensitivity and reduced tumors, while females exhibited increased lifespan and reduced glucose and oxidative stress.
Review
Endocrinology & Metabolism
John J. Kopchick, Reetobrata Basu, Darlene E. Berryman, Jens O. L. Jorgensen, Gudmundur Johannsson, Vishwajeet Puri
Summary: This review highlights the novel actions of growth hormone in fibrosis, cardiovascular function, and cancer, based on clinical data and studies on patients with acromegaly or growth hormone deficiency.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Review
Oncology
Reetobrata Basu, John J. Kopchick
Summary: This review article extensively discusses the role of growth hormone (GH) and insulin-like growth factor 1 (IGF1) in cancer treatment resistance, covering scientific evidence and the future need to exploit GH-IGF1 inhibition for successful cancer treatment.
ENDOCRINE-RELATED CANCER
(2023)
Article
Biochemistry & Molecular Biology
Patricia Mora-Criollo, Reetobrata Basu, Yanrong Qian, Kevin Funk, Stephen Bell, Jonathan A. A. Young, Edward O. O. List, Jaime A. A. Costales, Jaime Guevara-Aguirre, Mario J. J. Grijalva, John J. J. Kopchick
Summary: Chagas disease (CD) is a deadly parasitic disease that affects millions of people worldwide. This study investigates the effect of altered growth hormone (GH) levels on Trypanosoma cruzi infection, the causative agent of CD. The results suggest that high GH and low insulin growth factor-1 (IGF-1) levels, as seen in individuals with Laron syndrome (LS), provide partial protection against T. cruzi infection. This is the first study to report decreased T. cruzi infection using serum from modified mouse models with altered GH action, highlighting the importance of GH in CD pathogenesis.
Article
Biochemistry & Molecular Biology
Reetobrata Basu, Khairun Nahar, Prateek Kulkarni, Olivia Kerekes, Maya Sattler, Zachary Hall, Sebastian Neggers, Justin M. Holub, John J. Kopchick
Summary: A 16-residue peptide named S1H was designed and synthesized to inhibit the phosphorylation of STAT5 mediated by human growth hormone in cultured cells. It acts by inhibiting the interaction between hGH and the human growth hormone receptor, and can adopt an alpha-helix in solution. S1H not only mitigates phosphorylation of STAT5 but also acts as an antagonist for both lactogenic and somatotrophic hGH actions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)