Multifaceted role of IL-21 in rheumatoid arthritis: Current understanding and future perspectives

Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism

(2018) Matthieu Ruiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis

(2017) Charles Malemud   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases

(2017) Massimo Gadina et al.   JOURNAL OF AUTOIMMUNITY

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Novel treatment strategies in rheumatoid arthritis

(2017) Gerd R Burmester et al.   LANCET

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases

(2017) Medya M. Shikhagaie et al.   Nature Reviews Rheumatology

The complement system as a potential therapeutic target in rheumatic disease

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications

(2017) Zsuzsa Szondy et al.   PHARMACOLOGICAL RESEARCH

Mitogen-activated protein kinases as therapeutic targets for asthma

(2017) MirHojjat Khorasanizadeh et al.   PHARMACOLOGY & THERAPEUTICS

Synovial cellular and molecular markers in rheumatoid arthritis

(2017) M. Asif Amin et al.   Seminars in Immunopathology

Future therapeutic targets in rheumatoid arthritis?

(2017) Tommy Tsang Cheung et al.   Seminars in Immunopathology

The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells

(2017) Isabelle Corre et al.   Oncotarget

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

(2017) Debbie M. Roeleveld et al.   PLoS One

T follicular helper (Tfh) cells in normal immune responses and in allergic disorders

(2016) G. Varricchi et al.   ALLERGY

Increased sensitivity of rheumatoid synoviocytes to Schnurri-3 expression in TNF-α and IL-17A induced osteoblastic differentiation

(2016) Fabien Lavocat et al.   BONE

Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages

(2016) F. Vallières et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2016) R. Xing et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus

(2016) Xin Huang et al.   CLINICAL IMMUNOLOGY

Mitogen-activated protein kinase phosphatase-1: function and regulation in bone and related tissues

(2016) David T. Broome et al.   CONNECTIVE TISSUE RESEARCH

STAT3 signaling in immunity

(2016) Emily J. Hillmer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

T follicular helper cell programming by cytokine-mediated events

(2016) Kaitlin A. Read et al.   IMMUNOLOGY

Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL

(2016) Rui Xing et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Synovial IL-21/TNF-producing CD4 + T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes

(2016) Maria C. Lebre et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autophagy: controlling cell fate in rheumatic diseases

(2016) Jason S. Rockel et al.   Nature Reviews Rheumatology

The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases

(2016) Carla M. Cuda et al.   Nature Reviews Rheumatology

T Follicular Helper Cells in Transplantation

(2016) Giles Desmond Walters et al.   TRANSPLANTATION

IL-21 and T Cell Differentiation: Consider the Context

(2016) Yuan Tian et al.   TRENDS IN IMMUNOLOGY

Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells

(2016) Ze-Min Lin et al.   Scientific Reports

Regulation of Natural Killer Cell Function by STAT3

(2016) Nicholas A. Cacalano   Frontiers in Immunology

Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis

(2015) Kyoung-Woon Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of the synovial fibroblast in rheumatoid arthritis pathogenesis

(2015) Jason D. Turner et al.   CURRENT OPINION IN RHEUMATOLOGY

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

(2015) Ricardo C. Ferreira et al.   DIABETOLOGIA

The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis?

(2015) Charles J Malemud   Future Medicinal Chemistry

Treatment of IL-21R-Fc control autoimmune arthritis via suppression of STAT3 signal pathway mediated regulation of the Th17/Treg balance and plasma B cells

(2015) Jun-Geol Ryu et al.   IMMUNOLOGY LETTERS

The Ying and Yang of STAT3 in Human Disease

(2015) Tiphanie P. Vogel et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis

(2015) Ghasem Ghalamfarsa et al.   Journal of Immunotoxicology

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(2015) Karin Andersson et al.   MOLECULAR MEDICINE

A pathogenetic role for IL-21 in primary Sjögren syndrome

(2015) Seung-Ki Kwok et al.   Nature Reviews Rheumatology

Targeting GM-CSF in inflammatory diseases

(2015) Ian P. Wicks et al.   Nature Reviews Rheumatology

Cytokines in rheumatoid arthritis — shaping the immunological landscape

(2015) Iain B. McInnes et al.   Nature Reviews Rheumatology

Amplification of IL-21 signalling pathway through Bruton’s tyrosine kinase in human B cell activation

(2015) Sheau-Pey Wang et al.   RHEUMATOLOGY

Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis

(2015) R. Xing et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

(2015) Natalie A. Sims et al.   ARTHRITIS RESEARCH & THERAPY

CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis

(2015) Hidetoshi Tsushima et al.   ARTHRITIS RESEARCH & THERAPY

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

(2015) Chi-Keung Wan et al.   Nature Communications

Role of Bcl-3 in the Development of Follicular Helper T Cells and in the Pathogenesis of Rheumatoid Arthritis

(2015) Kazuyuki Meguro et al.   Arthritis & Rheumatology

The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis

(2015) Ceri A. Roberts et al.   Frontiers in Immunology

Role of Synovial Fibroblasts in Rheumatoid Arthritis

(2014) S. Lefevre et al.   CURRENT PHARMACEUTICAL DESIGN

STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation

(2014) S. A. Diehl et al.   JOURNAL OF IMMUNOLOGY

IL-21 Promotes CD4 T Cell Responses by Phosphatidylinositol 3-Kinase-Dependent Upregulation of CD86 on B Cells

(2014) K. Attridge et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Interleukin-6 Receptor Blockade Selectively Reduces IL-21 Production by CD4 T Cells and IgG4 Autoantibodies in Rheumatoid Arthritis

(2013) Gustavo Carbone et al.   International Journal of Biological Sciences

The Cellular Source and Target of IL-21 in K/BxN Autoimmune Arthritis

(2013) K. E. Block et al.   JOURNAL OF IMMUNOLOGY

Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

(2012) Jacques-Eric Gottenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 Triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells

(2012) Sean A Diehl et al.   IMMUNOLOGY AND CELL BIOLOGY

A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis

(2012) Rui Liu et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis

(2011) Seung-Ki Kwok et al.   ARTHRITIS AND RHEUMATISM

IL-21 regulates Th17 cells in rheumatoid arthritis

(2010) Xiaoyin Niu et al.   HUMAN IMMUNOLOGY

Increased Interleukin 21 (IL-21) and IL-23 Are Associated with Increased Disease Activity and with Radiographic Status in Patients with Early Rheumatoid Arthritis

(2010) T. K. RASMUSSEN et al.   JOURNAL OF RHEUMATOLOGY

Th17 cytokines and arthritis

(2010) Erik Lubberts   Seminars in Immunopathology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25- T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice

(2009) E. Jang et al.   JOURNAL OF IMMUNOLOGY

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer

(2008) Rosanne Spolski et al.   CURRENT OPINION IN IMMUNOLOGY

Neutralizing IL-21 and IL-15 Inhibits Pro-inflammatory Cytokine Production in Rheumatoid Arthritis

(2008) A. K. Andersson et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY