Article
Environmental Sciences
Wenjing Xie, Min Ling, Tian Xiao, Zi Fan, Dongya Chen, Meng Tang, Qian Bian
Summary: PM2.5 exposure induces changes in gene expression and cellular functions in human bronchial epithelial cells, and is positively correlated with lung injury. Tanshinone IIA can reverse the cell cycle alteration and cell proliferation caused by PM2.5.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Immunology
Kazuhiko Higashioka, Motoki Yoshimura, Takahide Sakuragi, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro
Summary: The identification of IL-21-producing PD-1(hi)CD8(+) T cells in patients with RA expands understanding of T cell subsets with B helper functions in the disease. Selective targeting of these subsets could lead to the development of novel treatment strategies for RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Felipe Valenca-Pereira, Qian Fang, Isabelle J. Marie, Emily L. Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David E. Levy, Mercedes Rincon
Summary: IL-6 enhances the mechanics of CD4 T cells, increasing their motility and mitochondrial Ca2+, ultimately improving their competitive fitness. This noncanonical pathway could lead to alternative therapeutic strategies for inflammatory diseases where IL-6 plays a pathogenic role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Cenhao Wu, Jun Ge, Ming Yang, Qi Yan, Yingjie Wang, Hao Yu, Huilin Yang, Jun Zou
Summary: In this study, resveratrol was found to improve nucleus pulposus cells' (NPCs) cell viability and inhibit cell apoptosis and cycle arrest. Additionally, resveratrol improved NPCs' degeneration by increasing the expression of heat shock protein 90 (HSP90) and N-Cadherin, as well as extracellular matrix components. Furthermore, resveratrol attenuated IL-6 secretion and inhibited JAK/STAT3 pathway phosphorylation, suggesting a protective effect against NPCs' degeneration.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuxi Ma, Yongyou Zhu, Li Shang, Yan Qiu, Na Shen, Jonathan Wang, Tiffany Adam, Wei Wei, Qingxuan Song, Jun Li, Max S. Wicha, Ming Luo
Summary: This study reveals that XIST plays a crucial role in regulating breast cancer stem cells by activating IL-6 proinflammatory signaling pathway. This finding is significant for understanding the mechanism of breast cancer development.
Article
Biochemistry & Molecular Biology
Chien-Hung Lin, Chuan Wan, Wen-Sheng Liu, Hsin-Hui Wang
Summary: Exposure to PM2.5 can induce EMT characteristics in HK-2 cells, with the IL-6/STAT3 pathway playing a key role in mediating early renal tubule cell injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Lihao Hu, Bingqian Huang, Shiyu Bai, Jianping Tan, Yukun Liu, Hailie Chen, Yong Liu, Liqiong Zhu, Jianping Zhang, Hui Chen
Summary: The study revealed that sulfur dioxide derivatives exert toxic effects on trophoblasts, leading to decreased cellular viability, reduced intracellular ROS levels, cell cycle arrest, apoptosis induction, abnormal secretion of inflammation-related cytokines, and inhibition of cell migration and invasion. Decreased levels of ROS/IL-6/STAT3 play a role in the inhibited cell viability, cell cycle arrest, apoptosis, and defective motility.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Melissa G. Lechner, Zikang Zhou, Aline T. Hoang, Nicole Huang, Jessica Ortega, Lauren N. Scott, Ho -Chung Chen, Anushi Y. Patel, Rana Yakhshi-Tafti, Kristy Kim, Willy Hugo, Pouyan Famini, Alexandra Drakaki, Antoni Ribas, Trevor E. Angell, Maureen A. Su
Summary: Autoimmune toxicity is an increasing challenge in using immune checkpoint inhibitors for cancer treatment. This study investigated the immune infiltrates in ICI-thyroiditis patients and identified a dominant population of cytotoxic CD8+ T cells. The researchers also found that interleukin-21 played a crucial role in the formation of these thyrotoxic CD8+ T cells and validated the findings in a mouse model. These findings provide insights into the mechanisms and potential therapeutic targets for individuals with IRAEs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Chang -Zhu Pei, Jin Seok, Gi Jin Kim, Bum-Chae Choi, Kwang-Hyun Baek
Summary: Through the study of the BeWo KO cell line, which lacks high-temperature requirement factor A4 (HtrA4), it was found that the deficiency of HtrA4 inhibits IL-6 expression in trophoblasts and reduces VEGFA expression in HUVECs, thus weakening the ability of tube formation. Rescue of HtrA4 expression can restore the tube formation ability of HUVECs. These findings suggest that HtrA4 deficiency hinders angiogenesis and may contribute to placental dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Hyo In Kim, Sol Ji Lee, Yu-Jeong Choi, Min Jeong Kim, Tai Young Kim, Seong-Gyu Ko
Summary: This study found that quercetin can induce apoptosis in GBM cells by inhibiting the Axl/IL-6/STAT3 signaling pathway, suggesting its potential as an anticancer agent.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Immunology
Xiaoman Guo, Xinru Mao, Di Tian, Yixin Liao, Bintao Su, Chaoliang Ye, Dongling Shi, Tie Fu Liu, Yun Ling, Yi Hao
Summary: Cryptococcus neoformans infection in the central nervous system leads to high levels of IL-17 production, mainly by CD4(+) T cells, and is dependent on STAT3 signaling. IL-17 could serve as a diagnostic biomarker for C. neoformans infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xin Chen, Chennan Wang, Na Sun, Shuai Pan, Rongqing Li, Xueqin Li, Jie Zhao, Huan Tong, Yangyang Tang, Jing Han, Jianlin Qiao, Hongbin Qiu, Hui Wang, Jing Yang, Takayuki Ikezoe
Summary: This study revealed that deletion of Aurka in CD19(+) B cells results in increased production of IL-6, promoting STAT3 activation, which in turn contributes to TPO transcription and megakaryocytopoiesis.
Article
Immunology
Yuzhuo Yang, Yajing Zhang, Xiaoyan Xing, Gang Xu, Xin Lin, Yao Wang, Meixia Chen, Chunmeng Wang, Bin Zhang, Weidong Han, Xiaoyu Hu
Summary: Metoprolol, an FDA-approved drug for cardiovascular conditions, may alleviate cytokine release syndrome (CRS) caused by CAR T-cell therapy. It was found that metoprolol blocks IL-6 protein translation rather than IL-6 mRNA expression. Clinical trials have shown that metoprolol has a favorable safety profile in CRS management and does not compromise the efficacy of CAR T-cell therapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemical Research Methods
Lina Bartels, Hidde L. Ploegh, Hergen Spits, Koen Wagner
Article
Public, Environmental & Occupational Health
James A. Church, Sandra Rukobo, Margaret Govha, Marya P. Carmolli, Sean A. Diehl, Bernard Chasekwa, Robert Ntozini, Kuda Mutasa, Jean H. Humphrey, Beth D. Kirkpatrick, Andrew J. Prendergast
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2019)
Correction
Immunology
Maho Nagasawa, Balthasar A. Heesters, Chantal M. A. Kradolfer, Lisette Krabbendam, Itziar Martinez-Gonzalez, Marjolein J. W. de Bruijn, Korneliusz Golebski, Rudi W. Hendriks, Ralph Stadhouders, Hergen Spits, Suzanne M. Bal
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Virology
Alba Grifoni, Hannah Voic, Sandeep Kumar Dhanda, Conner K. Kidd, James D. Brien, Soren Buus, Anette Stryhn, Anna P. Durbin, Stephen Whitehead, Sean A. Diehl, Aruna D. De Silva, Angel Balmaseda, Eva Harris, Daniela Weiskopf, Alessandro Sette
JOURNAL OF VIROLOGY
(2020)
Article
Cell Biology
Hendy Kristyanto, Nienke J. Blomberg, Linda M. Slot, Ellen I. H. van der Voort, Priscilla F. Kerkman, Aleida Bakker, Leonie E. Burgers, Robin M. ten Brinck, Annette H. M. van der Helm-van Mil, Hergen Spits, Dominique L. Baeten, Tom W. J. Huizinga, Rene E. M. Toes, Hans U. Scherer
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Usha K. Nivarthi, Jesica Swanstrom, Matthew J. Delacruz, Bhumi Patel, Anna P. Durbin, Steve S. Whitehead, Beth D. Kirkpatrick, Kristen K. Pierce, Sean A. Diehl, Leah Katzelnick, Ralph S. Baric, Aravinda M. de Silva
Summary: The study showed that the TV003 vaccine can stimulate balanced and serotype-specific neutralizing antibody responses to all four serotypes of dengue virus. Most of the 21 dengue-naive individuals in the study developed serotype-specific neutralizing antibodies to 3 or 4 DENV serotypes after vaccination.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Balthasar A. Heesters, Kyah van Megesen, Ilhan Tomris, Robert P. de Vries, Giuliana Magri, Hergen Spits
Summary: FDCs play a crucial role in germinal centers by interacting with B cells and maintaining antigen gradients, while their transcriptome is still incompletely defined and some functions are substituted by MRCs and other cells. FDCs also express various genes related to T cell regulation, indicating an intimate connection with T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Editorial Material
Immunology
Hergen Spits
Article
Multidisciplinary Sciences
L. Krabbendam, B. A. Heesters, C. M. A. Kradolfer, N. J. E. Haverkate, M. A. J. Becker, C. J. Buskens, W. A. Bemelman, J. H. Bernink, H. Spits
Summary: The study identifies two populations of CD127+CD94+ ILCs in the intestinal lamina propria, designated as population A and B, with population B expressing granulysin. Granulysin-expressing effector CD127+CD94+ ILCs are shown to be expanded in patients with Crohn's disease. The overlapping phenotypic markers between ILC1 and NK populations have impacted the specific analysis of these immune cell populations.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Efthymia Kokkinou, Ram Vinay Pandey, Luca Mazzurana, Irene Gutierrez-Perez, Christopher Andrew Tibbitt, Whitney Weigel, Tea Soini, Anna Carrasco, Anna Rao, Maho Nagasawa, Suzanne M. Bal, Mattias Jangard, Danielle Friberg, Ulrik Lindforss, Caroline Nordenvall, Malin Ljunggren, Staffan Haapaniemi, Asa V. Keita, Johan Soderholm, Charlotte Hedin, Hergen Spits, Yenan T. Bryceson, Jenny Mjosberg
Summary: In this study, researchers discovered different subsets of ILCs expressing CD45RA in tissues, which can further be divided into two subgroups based on the expression of CD62L. These two subgroups showed differences in transcription, metabolism, epigenetics, and cytokine production, as well as distinct effector functions after differentiation. These findings have important implications for understanding the biology of ILCs in health and disease.
SCIENCE IMMUNOLOGY
(2022)
Article
Allergy
Korneliusz Golebski, Rik Johannes Leonardus van Der Lans, Danielle van Egmond, Esther de Groot, Hergen Spits, Anke-Hilse Maitland-van Der Zee, Cornelis Maria van Drunen, Wytske Johanna Fokkens, Sietze Reitsma
Letter
Immunology
Loems Ziegler-Heitbrock, Toshiaki Ohteki, Florent Ginhoux, Ken Shortman, Hergen Spits
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Immunology
Hergen Spits, Jenny Mjosberg
Summary: Type 2 innate lymphoid cells (ILC2s) display diverse phenotypes across tissues and diseases, playing crucial roles in tissue homeostasis, repair, and the regulation of other immune cells. Dysregulation of ILC2s is involved in the pathogenesis of various diseases, making ILC2s attractive targets for therapeutic interventions.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Eline M. van den Broek-Altenburg, Adam J. Atherly, Sean A. Diehl, Kelsey M. Gleason, Victoria C. Hart, Charles D. MacLean, Daniel A. Barkhuff, Mark A. Levine, Jan K. Carney
Summary: This study focuses on the prevalence of COVID-19 in an asymptomatic population within a hospital service area (HSA) and identifies factors that affect exposure to the virus. The results show that a higher number of daily contacts with adults and older adults increases the probability of infection, while occupation, living situation, and mask-wearing behaviors can also impact the number of daily contacts. The findings suggest that nonclinical factors such as behavior and living environment may contribute to increased SARS-CoV-2 exposure.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Review
Immunology
Suzanne M. Bal, Korneliusz Golebski, Hergen Spits
NATURE REVIEWS IMMUNOLOGY
(2020)