Article
Oncology
Yan-Hong Liu, Man Zhu, Pan-Pan Lei, Xiao-Yan Pan, Wei-Na Ma
Summary: The study revealed that the novel compound ND-09 inhibited CML cell growth by targeting BCR-ABL and altering its kinase activity, ultimately leading to growth arrest in CML cells.
Article
Chemistry, Multidisciplinary
Bohan Ma, Hui Feng, Chao Feng, Yi Liu, Hailing Zhang, Jincheng Wang, Wenjuan Wang, Pengcheng He, Fan Niu
Summary: The study designed a dual-targeting proteolysis-targeting chimera (PROTAC) type drug that can induce Bcr/Abl degradation and activate the p53 pathway simultaneously, potentially overcoming drug resistance in Ph+ leukemias.
Article
Hematology
Juan Li, Yanfang Zhang, Yubo Cui, Honghua Jin, Zhenhua Lin, Yingshi Piao, Jingchun Jin
Summary: The study suggests that CD44 might be involved in adriamycin resistance in chronic myelogenous leukaemia cells K562 by regulating P-gp, MMP-2, MMP-9, and Bcl-2/Bax.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Jianming Wang, Yang Liang, Yuefeng Qin, Guoyun Jiang, Yuhang Peng, Wenli Feng
Summary: This study uncovers that circCRKL is specifically expressed and regulates the expression level of BCR-ABL via decoying miR-877-5p in BCR-ABL(+) cells. The findings suggest that targeting circCRKL along with imatinib treatment could be a potential therapeutic strategy for CML patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yijing Ren, Cheng Lv, Jing Zhang, Beibei Zhang, Bei Yue, Xiaoping Luo, Zhilun Yu, Hao Wang, Junyu Ren, Zhengtao Wang, Wei Dou
Summary: Alantolactone (ATL) exhibits inhibitory effects on cell activities, induces apoptosis, and inhibits colony formation in colorectal cancer. It also reduces cell migration and invasion capabilities. Furthermore, ATL demonstrates significant anti-tumor effects in vivo models.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Ting-Ting Huang, Xin Wang, Shao-Jia Qiang, Zhen-Nan Zhao, Zhuo-Xun Wu, Charles R. Ashby, Jia-Zhong Li, Zhe-Sheng Chen
Summary: The study identified a potential BCR-ABL inhibitor, ZINC21710815, through drug design and screening, which effectively inhibited the proliferation of different types of leukemia cells, inducing cell cycle arrest and apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yuan Tan, Zhenglan Huang, Xin Wang, Hongdan Dai, Guoyun Jiang, Wenli Feng
Summary: This study identified a novel fusion circRNA (F-circBA1) originating from BCR-ABL, which is mainly localized in the cytoplasm and plays an oncogenic role in CML cells.
Article
Cell Biology
Xiaofang Chen, Xianling Chen, Yiping Huang, Jia Lin, Yong Wu, Yuanzhong Chen
Summary: In this study, it was found that elevated expression of TCP1 in acute myeloid leukemia patients was associated with low complete response rate and poor overall survival. Further investigations revealed that TCP1 contributes to drug resistance by inhibiting autophagy and activating the AKT/mTOR signaling pathway. Targeting the TCP1/AKT/mTOR signaling pathway provides a new strategy for overcoming drug resistance in AML.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Shaojie Yang, Wanlin Dai, Jingnan Wang, Xiaolin Zhang, Yuting Zheng, Shiyuan Bi, Liwei Pang, Tengqi Ren, Ye Yang, Yang Sun, Zhuyuan Zheng, Shuodong Wu, Jing Kong
Summary: Cancer is a global health problem with high incidence and mortality rates. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss., has shown promising anticancer effects. Studies have revealed that osthole inhibits cancer cell proliferation, induces apoptosis, suppresses migration and invasion, inhibits angiogenesis, enhances sensitivity to chemotherapy drugs, and reverses multidrug resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tom C. Karagiannis, Meaghan Wall, Katherine Ververis, Eleni Pitsillou, Stephanie M. Tortorella, Peter A. Wood, Haloom Rafehi, Ishant Khurana, Scott S. Maxwell, Andrew Hung, Jitraporn Vongsvivut, Assam El-Osta
Summary: Human erythroleukemic K562 cells are a widely used cell culture model for studying chronic myeloid leukemia (CML). They have been used to investigate the BCR/ABL1 oncogene, drug resistance, and targeted therapies. This study provides a comprehensive characterization of K562 cells, including their karyotype, TfR expression, and response to HDAC inhibition. The findings highlight the importance of K562 cells in the development of novel therapeutics for CML.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tingting Lu, Jiangyan Cao, Fengming Zou, Xixiang Li, Aoli Wang, Wenliang Wang, Huamin Liang, Qingwang Liu, Chen Hu, Cheng Chen, Zhenquan Hu, Wenchao Wang, Lili Li, Jian Ge, Yang Shen, Tao Ren, Jing Liu, Ruixiang Xia, Qingsong Liu
Summary: CHMFL-48 is a novel type II kinase inhibitor that potently inhibits the wild-type BCR-ABL kinase and a panel of imatinib-resistant mutants. This drug shows strong inhibitory activity in a cellular context, blocking autophosphorylation of BCR-ABL kinase, affecting downstream signaling mediators, and inducing cell cycle progression blockade and apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hong Zhang, Ting Song, Ziqian Wang, Yafei Guo, Hang Wang, Qishuang Gao, Zhichao Zhang, Uwituze Laura Bonneete
Summary: By using a specific inhibitor of Hsp70/Bim complex and knocking down Bcr-Abl, researchers have found that Bcr-Abl can prevent cell apoptosis by driving the formation of Hsp70/Bim complex. Additionally, Bcr-Abl can stabilize oncogenic clients by driving the formation of Hsp70/Bim complex.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Wei Guo, Xing Liu, Lianjie Ye, Jie Liu, Kollie Larwubah, Ge Meng, Weiqiang Shen, Xiangxian Ying, Jun Zhu, Shengjie Yang, Jianjun Guo, Yanrong Jia, Meilan Yu
Summary: Hydroxylated fullerene C-60(OH)(n) (n = 18-22) has both growth-promoting and inhibitory effects on leukemia cells, with high concentrations leading to cell death.
Review
Pharmacology & Pharmacy
Meike Kaehler, Ingolf Cascorbi
Summary: The use of small molecules, such as tyrosine kinase inhibitors (TKIs), is crucial in targeted anti-cancer therapy, especially in treating chronic myelogenous leukemia (CML). While TKIs like imatinib or nilotinib show high effectiveness in CML patients, treatment failure can still occur in some cases, either dependent or independent from the BCR-ABL1 kinase.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Fanjun Li, Monifa Fahie, Kaitlyn Gilliam, Ryan Pham, Min Chen
Summary: The authors demonstrate that protein nanopore tweezers can be used to analyze the conformational energy landscape and ligand binding of the Abl kinase domain. They identify two major conformational states of the kinase domain and reveal the functional roles of these states in substrate and inhibitor interactions. The results provide insights into the dynamic nature of Abl kinase and suggest that nanopore tweezers can be an efficient tool for studying other members of the human kinome.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Tahir Mehmood, Amara Maryam, Xiangge Tian, Muhammad Khan, Tonghui Ma
Review
Medicine, General & Internal
Jingzhou Mu, Qiuyu Chen, Liang Zhu, Yunhong Wu, Suping Liu, Yufei Zhao, Tonghui Ma
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Medicine, Research & Experimental
Yan Yang, Kai Xue, Zhi Li, Wei Zheng, Weijie Dong, Jiazhe Song, Shijie Sun, Tonghui Ma, Wenzhe Li
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Mycology
L. F. Yang, X. Liu, L. L. Lv, Z. M. Ma, X. C. Feng, T. H. Ma
JOURNAL DE MYCOLOGIE MEDICALE
(2018)
Article
Cell Biology
Amara Maryam, Tahir Mehmood, Qiulong Yan, Yongming Li, Muhammad Khan, Tonghui Ma
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Pharmacology & Pharmacy
Bo Yu, Yu Jiang, Bo Zhang, Hong Yang, Tonghui Ma
PHARMACOLOGICAL RESEARCH
(2018)
Article
Immunology
Wei Liang, Shanshan Mao, Shijie Sun, Ming Li, Zhi Li, Rui Yu, Tonghui Ma, Jianguo Gu, Jianing Zhang, Naoyuki Taniguchi, Wenzhe Li
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Zhuo Liu, Miao Yu, Bingyuan Fei, Xuedong Fang, Tonghui Ma, Dongxin Wang
Article
Physiology
Dejiang Wang, Xiangjun Di, Jie Wang, Miao Li, Di Zhang, Yaxin Hou, Jiao Hu, Ge Zhang, He Zhang, Meiyan Sun, Xiangyu Meng, Bo Sun, Chunlai Jiang, Tonghui Ma, Weiheng Su
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Hematology
Mingcheng Liu, Qiwang Liu, Yandong Pei, Miaomiao Gong, Xiaolin Cui, Jinjin Pan, Yunlong Zhang, Yang Liu, Ying Liu, Xiaocheng Yuan, Haoran Zhou, Yiying Chen, Jian Sun, Lin Wang, Xiya Zhang, Rui Wang, Shao Li, Jizhong Cheng, Yanchun Ding, Tonghui Ma, Yuhui Yuan
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Xiaoxue Lv, Jiazhe Song, Kai Xue, Zhi Li, Ming Li, Danishi Zahid, Hongyu Cao, Lu Wang, Wanli Song, Tonghui Ma, Jianguo Gu, Wenzhe Li
MOLECULAR CARCINOGENESIS
(2019)
Article
Biotechnology & Applied Microbiology
Jie Wang, Miao Li, Xiaolin Cui, Dongyue Lv, Lingling Jin, Muhammad Khan, Tonghui Ma
ONCOTARGETS AND THERAPY
(2018)
Article
Biotechnology & Applied Microbiology
Longfei Yang, Xin Liu, Lili Zhong, Yujie Sui, Guihua Quan, Ying Huang, Fang Wang, Tonghui Ma
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Jing Xu, Hebin Sun, Guoling Huang, Gang Liu, Zhi Li, Hui Yang, Lingling Jin, Xiaolin Cui, Lei Shi, Tonghui Ma, Akihiko Kameyama, Weijie Dong
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Longfei Yang, Xin Liu, Yujie Sui, Zhiming Ma, Xuechao Feng, Fang Wang, Tonghui Ma
BIOMED RESEARCH INTERNATIONAL
(2019)