Regulation and dysregulation of axon infrastructure by myelinating glia

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination

(2017) Verena Schultz et al.   GLIA

Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons

(2017) Julia Saifetiarova et al.   JOURNAL OF NEUROSCIENCE

Periodic actin structures in neuronal axons are required to maintain microtubules

(2017) Yue Qu et al.   MOLECULAR BIOLOGY OF THE CELL

Formation and disruption of functional domains in myelinated CNS axons

(2017) Ryan B. Griggs et al.   NEUROSCIENCE RESEARCH

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function

(2017) Anna M. Taylor et al.   Frontiers in Cellular Neuroscience

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

(2017) Nicolas Snaidero et al.   Cell Reports

Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

(2017) Michael Krieg et al.   eLife

The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier

(2017) Veronique Amor et al.   eLife

Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach

(2016) Katharina Marie Höflich et al.   BRAIN RESEARCH

Electron microscopy of myelin: Structure preservation by high-pressure freezing

(2016) Wiebke Möbius et al.   BRAIN RESEARCH

Cytoskeletal control of axon domain assembly and function

(2016) Chuansheng Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

(2016) Xinghua Yin et al.   JOURNAL OF CELL BIOLOGY

Seeing is believing – multi-scale spatio-temporal imaging towardsin vivocell biology

(2016) Gautier Follain et al.   JOURNAL OF CELL SCIENCE

Disrupted axon-glia interactions at the paranode in myelinated nerves cause axonal degeneration and neuronal cell death in the aged Caspr mutant mouse shambling

(2016) Yoshiko Takagishi et al.   NEUROBIOLOGY OF AGING

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy

(2016) Elisa D’Este et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

(2016) Jiang He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

(2016) Carla Garza-Lombó et al.   Frontiers in Cellular Neuroscience

Structural basis of myelin-associated glycoprotein adhesion and signalling

(2016) Matti F. Pronker et al.   Nature Communications

Subcortical cytoskeleton periodicity throughout the nervous system

(2016) Elisa D’Este et al.   Scientific Reports

The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter

(2016) Sérgio Carvalho Leite et al.   Cell Reports

A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

(2016) Kristina D Micheva et al.   eLife

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

(2016) Feng Mei et al.   eLife

Subcellular Patterning: Axonal Domains with Specialized Structure and Function

(2015) Elizabeth A. Normand et al.   DEVELOPMENTAL CELL

SPTAN1 encephalopathy: distinct phenotypes and genotypes

(2015) Jun Tohyama et al.   JOURNAL OF HUMAN GENETICS

Apoptosis of Oligodendrocytes during Early Development Delays Myelination and Impairs Subsequent Responses to Demyelination

(2015) A. V. Caprariello et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold

(2015) Christophe Leterrier et al.   Cell Reports

The axonal cytoskeleton: from organization to function

(2015) Josta T. Kevenaar et al.   Frontiers in Molecular Neuroscience

A New Model of Cuprizone-Mediated Demyelination/Remyelination

(2014) Hilary H. Sachs et al.   ASN Neuro

A PIK3C3–Ankyrin-B–Dynactin pathway promotes axonal growth and multiorganelle transport

(2014) Damaris Nadia Lorenzo et al.   JOURNAL OF CELL BIOLOGY

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction

(2014) R. Villegas et al.   JOURNAL OF NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Local Regulation of Neurofilament Transport by Myelinating Cells

(2014) P. C. Monsma et al.   JOURNAL OF NEUROSCIENCE

A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

(2014) Tammy Szu-Yu Ho et al.   NATURE NEUROSCIENCE

Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

(2014) Catherine Diamante Sorbara et al.   NEURON

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

(2014) Nobuhiko Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of MEC-17 Leads to Microtubule Instability and Axonal Degeneration

(2014) Brent Neumann et al.   Cell Reports

Developmental mechanism of the periodic membrane skeleton in axons

(2014) Guisheng Zhong et al.   eLife

Membrane domain organization of myelinated axons requires βII spectrin

(2013) Chuansheng Zhang et al.   JOURNAL OF CELL BIOLOGY

Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon

(2013) Marek Ma   NEUROBIOLOGY OF DISEASE

Three Mechanisms Assemble Central Nervous System Nodes of Ranvier

(2013) Keiichiro Susuki et al.   NEURON

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

(2013) Jing Yang et al.   NEURON

Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination

(2012) Andrew V. Caprariello et al.   ANNALS OF NEUROLOGY

Targeted Ablation of Oligodendrocytes Induces Axonal Pathology Independent of Overt Demyelination

(2012) L.-J. Oluich et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

(2012) Benjamin Schattling et al.   NATURE MEDICINE

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease

(2011) Fredrik I. Gruenenfelder et al.   JOURNAL OF ANATOMY

Cell organization, growth, and neural and cardiac development require  II-spectrin

(2011) M. C. Stankewich et al.   JOURNAL OF CELL SCIENCE

Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage

(2011) H. B. F. Pohl et al.   JOURNAL OF NEUROSCIENCE

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Dominant-Negative Mutations in α-II Spectrin Cause West Syndrome with Severe Cerebral Hypomyelination, Spastic Quadriplegia, and Developmental Delay

(2010) Hirotomo Saitsu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

(2010) Maria Traka et al.   BRAIN

Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells

(2010) Bo Huang et al.   CELL

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration inDrosophila

(2010) Damaris N. Lorenzo et al.   JOURNAL OF CELL BIOLOGY

Demyelination Increases Axonal Stationary Mitochondrial Size and the Speed of Axonal Mitochondrial Transport

(2010) S. Kiryu-Seo et al.   JOURNAL OF NEUROSCIENCE

Myelination and the trophic support of long axons

(2010) Klaus-Armin Nave   NATURE REVIEWS NEUROSCIENCE

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation

(2010) David P. Stirling et al.   TRENDS IN MOLECULAR MEDICINE

Myelin-Associated Glycoprotein (MAG) Protects Neurons from Acute Toxicity Using a Ganglioside-Dependent Mechanism

(2009) Niraj R. Mehta et al.   ACS Chemical Neuroscience

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

A Novel Caspr Mutation Causes the Shambling Mouse Phenotype by Disrupting Axoglial Interactions of Myelinated Nerves

(2009) Xiao-yang Sun et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disruption of the Axon Initial Segment Cytoskeleton Is a New Mechanism for Neuronal Injury

(2009) D. P. Schafer et al.   JOURNAL OF NEUROSCIENCE

Axonal Protective Effects of the Myelin-Associated Glycoprotein

(2009) T. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

AnkyrinG is required to maintain axo-dendritic polarity in vivo

(2009) J.-M. Sobotzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis

(2008) Getaw Worku Hassen et al.   BRAIN RESEARCH

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

(2008) Kristian L. Hedstrom et al.   JOURNAL OF CELL BIOLOGY

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

A Hypothesis About the Relationship of Myelin-Associated Glycoprotein’s Function in Myelinated Axons to its Capacity to Inhibit Neurite Outgrowth

(2008) Richard H. Quarles   NEUROCHEMICAL RESEARCH

Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy

(2008) B. Huang et al.   SCIENCE

Glutamate Receptor Expression in Multiple Sclerosis Lesions

(2007) Jia Newcombe et al.   BRAIN PATHOLOGY