RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis
出版年份 2012 全文链接
标题
RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis
作者
关键词
-
出版物
Cancers
Volume 4, Issue 4, Pages 1106-1145
出版商
MDPI AG
发表日期
2012-10-26
DOI
10.3390/cancers4041106
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- A multicenter phase I study of DI17E6, a novel de-immunized monoclonal antibody to human αv integrins, in progressive castrate-resistant prostate cancer (CRPC) with bone metastases after chemotherapy.
- (2017) M. Wirth et al. JOURNAL OF CLINICAL ONCOLOGY
- Final analysis: A multicenter phase I study of EMD 525797 (DI17E6), a novel humanized monoclonal antibody to human αv integrins, in progressive castrate-resistant prostate cancer with bone metastases after chemotherapy.
- (2017) Manfred Wirth et al. JOURNAL OF CLINICAL ONCOLOGY
- Molecular Ultrasound Imaging of Early Vascular Response in Prostate Tumors Irradiated with Carbon Ions
- (2015) Moritz Palmowski et al. NEOPLASIA
- Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer
- (2015) Geertje van der Horst et al. NEOPLASIA
- Molecular Markers and Death From Prostate Cancer
- (2013) John Concato ANNALS OF INTERNAL MEDICINE
- αVβ3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug
- (2012) Nora Graf et al. ACS Nano
- Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells
- (2012) Dongxuan Jia et al. BMC CANCER
- Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β3 affinity modulation
- (2012) A Goc et al. BRITISH JOURNAL OF CANCER
- Role of α5β1 and αvβ3 integrins in relation to adhesion and spreading dynamics of prostate cancer cells interacting with fibronectin underin vitroconditions
- (2012) Anna Stachurska et al. CELL BIOLOGY INTERNATIONAL
- Defining the Role of Integrin αvβ6 in Cancer
- (2012) A. Bandyopadhyay et al. CURRENT DRUG TARGETS
- Tumor-platelet interaction in solid tumors
- (2012) Daniel Buergy et al. INTERNATIONAL JOURNAL OF CANCER
- Mena binds α5 integrin directly and modulates α5β1 function
- (2012) Stephanie L. Gupton et al. JOURNAL OF CELL BIOLOGY
- Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor
- (2012) Masamichi Nagae et al. JOURNAL OF CELL BIOLOGY
- Ultrasound Microbubbles for Molecular Diagnosis, Therapy, and Theranostics
- (2012) F. Kiessling et al. JOURNAL OF NUCLEAR MEDICINE
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- 64Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH2: a heterodimeric targeting vector for positron emission tomography imaging of prostate cancer
- (2012) Andrew B. Jackson et al. NUCLEAR MEDICINE AND BIOLOGY
- Combination of RGD Compound and Low-Dose Paclitaxel Induces Apoptosis in Human Glioblastoma Cells
- (2012) Ming-Wei Chang et al. PLoS One
- Low dosed interferon alpha augments the anti-tumor potential of histone deacetylase inhibition on prostate cancer cell growth and invasion
- (2012) Lukasz Hudak et al. PROSTATE
- Zoledronic acid influences growth, migration and invasive activity of prostate cancer cells in vitro
- (2012) J Mani et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Integrin Targeted Imaging and Therapy
- (2012) Xiaoyuan Chen Theranostics
- Integrin Targeted Delivery of Chemotherapeutics
- (2012) Kai Chen et al. Theranostics
- Matched rabbit monoclonal antibodies against v-series integrins reveal a novel v 3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors
- (2012) S. L. Goodman et al. Biology Open
- Emerging Targeted Therapies for Castration-Resistant Prostate Cancer
- (2012) Vincenzo Adamo et al. Frontiers in Endocrinology
- Integrin αv Expression Is Required for the Acquisition of a Metastatic Stem/Progenitor Cell Phenotype in Human Prostate Cancer
- (2011) Christel van den Hoogen et al. AMERICAN JOURNAL OF PATHOLOGY
- Increasing αvβ3 Selectivity of the Anti-Angiogenic Drug Cilengitide by N-Methylation
- (2011) Carlos Mas-Moruno et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
- (2011) Carlos Mas-Moruno et al. Anti-Cancer Agents in Medicinal Chemistry
- αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins
- (2011) Céline Defilles et al. BIOLOGY OF THE CELL
- Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis
- (2011) Steffen Wedel et al. BMC CANCER
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β
- (2011) Anna Bianchi et al. CELL CYCLE
- Impact of combined HDAC and mTOR inhibition on adhesion, migration and invasion of prostate cancer cells
- (2011) Steffen Wedel et al. CLINICAL & EXPERIMENTAL METASTASIS
- The role of β3-integrins in tumor angiogenesis: context is everything
- (2011) Stephen D Robinson et al. CURRENT OPINION IN CELL BIOLOGY
- Bone-metastatic prostate carcinoma favors mesenchymal stem cell differentiation toward osteoblasts and reduces their osteoclastogenic potential
- (2011) V. Fritz et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy
- (2011) Khaled Greish et al. JOURNAL OF CONTROLLED RELEASE
- Biological evaluation of RGDfK-gold nanorod conjugates for prostate cancer treatment
- (2011) Adam J. Gormley et al. JOURNAL OF DRUG TARGETING
- Integrin v 5-Mediated TGF- Activation by Airway Smooth Muscle Cells in Asthma
- (2011) A. L. Tatler et al. JOURNAL OF IMMUNOLOGY
- Macrophage-Dependent Cleavage of the Laminin Receptor 6 1 in Prostate Cancer
- (2011) I. C. Sroka et al. MOLECULAR CANCER RESEARCH
- Comparison of Active and Passive Targeting of Docetaxel for Prostate Cancer Therapy by HPMA Copolymer–RGDfK Conjugates
- (2011) Abhijit Ray et al. MOLECULAR PHARMACEUTICS
- Tumor angiogenesis: molecular pathways and therapeutic targets
- (2011) Sara M Weis et al. NATURE MEDICINE
- Prostate cancer targeting motifs: Expression of ανβ3, neurotensin receptor 1, prostate specific membrane antigen, and prostate stem cell antigen in human prostate cancer cell lines and xenografts
- (2011) Robert M. Taylor et al. PROSTATE
- Development of a chimeric recombinant disintegrin as a cost-effective anti-cancer agent with promising translational potential
- (2011) Radu Minea et al. TOXICON
- Snail negatively regulates cell adhesion to extracellular matrix and integrin expression via the MAPK pathway in prostate cancer cells
- (2011) Corey L. Neal et al. Cell Adhesion & Migration
- BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression
- (2011) Hildegonda P. H. Naber et al. CELLULAR ONCOLOGY
- Components of Cell-Matrix Linkage as Potential New Markers for Prostate Cancer
- (2011) Alexey Navdaev et al. Cancers
- A new 18F-labeled BBN-RGD peptide heterodimer with a symmetric linker for prostate cancer imaging
- (2010) Yongjun Yan et al. AMINO ACIDS
- Integrins, growth factors, and the osteoclast cytoskeleton
- (2010) Wei Zou et al. Annals of the New York Academy of Sciences
- Evaluation of the safety, pharmacokinetics and treatment effects of an ανβ3integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases
- (2010) Mark A ROSENTHAL et al. Asia-Pacific Journal of Clinical Oncology
- A multimodal nanoparticle-based cancer imaging probe simultaneously targeting nucleolin, integrin αvβ3 and tenascin-C proteins
- (2010) Hae Young Ko et al. BIOMATERIALS
- Epithelial plasticity, cancer stem cells and bone metastasis formation
- (2010) Gabri van der Pluijm BONE
- Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions
- (2010) Jochen G. Schneider et al. BONE
- Combined targeting of the VEGFr/EGFr and the mammalian target of rapamycin (mTOR) signaling pathway delays cell cycle progression and alters adhesion behavior of prostate carcinoma cells
- (2010) Steffen Wedel et al. CANCER LETTERS
- Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation
- (2010) Hongren Yao et al. CLINICAL & EXPERIMENTAL METASTASIS
- TGF-β Pathway as a Therapeutic Target in Bone Metastases
- (2010) Patricia Juarez et al. CURRENT PHARMACEUTICAL DESIGN
- Endothelial 5 and v integrins cooperate in remodeling of the vasculature during development
- (2010) A. van der Flier et al. DEVELOPMENT
- Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing
- (2010) Coert Margadant et al. EMBO REPORTS
- Fibroblast and prostate tumor cell cross-talk: Fibroblast differentiation, TGF-β, and extracellular matrix down-regulation
- (2010) Vivien J. Coulson-Thomas et al. EXPERIMENTAL CELL RESEARCH
- A phase 1, multicenter, open-label study of the safety of two dose levels of a human monoclonal antibody to human αv integrins, intetumumab, in combination with docetaxel and prednisone in patients with castrate-resistant metastatic prostate cancer
- (2010) Franklin M. Chu et al. INVESTIGATIONAL NEW DRUGS
- Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium
- (2010) Deborah A. Bradley et al. INVESTIGATIONAL NEW DRUGS
- Leptin increases motility and integrin up-regulation in human prostate cancer cells
- (2010) Chih-Yang Huang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Radionuclide and hybrid imaging of recurrent prostate cancer
- (2010) Ambros J Beer et al. LANCET ONCOLOGY
- A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis
- (2010) J H Tchaicha et al. ONCOGENE
- Critical analysis of simultaneous blockage of histone deacetylase and multiple receptor tyrosine kinase in the treatment of prostate cancer
- (2010) Steffen Wedel et al. PROSTATE
- Association between integrin expression and prognosis in localized prostate cancer
- (2010) José Pontes-Júnior et al. PROSTATE
- Metastasis: tumor cells becoming MENAcing
- (2010) Frank Gertler et al. TRENDS IN CELL BIOLOGY
- Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells
- (2010) Sajni Josson et al. Journal of Oncology
- Positron emission tomography imaging of prostate cancer
- (2009) Hao Hong et al. AMINO ACIDS
- Single and combined effects of αvβ3- and α5β1-integrins on capillary tube formation in a human fibrinous matrix
- (2009) Nancy Laurens et al. ANGIOGENESIS
- Functionalized Cyclic RGD Peptidomimetics: Conjugable ligands for αvβ3Receptor Imaging
- (2009) Daniela Arosio et al. BIOCONJUGATE CHEMISTRY
- Enhanced drug targeting by attachment of an anti αv integrin antibody to doxorubicin loaded human serum albumin nanoparticles
- (2009) Sylvia Wagner et al. BIOMATERIALS
- Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data
- (2009) Ivan P Gorlov et al. BMC Medical Genomics
- Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors
- (2009) Kazuki N. Sugahara et al. CANCER CELL
- Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion
- (2009) Shailesh Singh et al. CANCER LETTERS
- Extracellular Engagement of 6 Integrin Inhibited Urokinase-Type Plasminogen Activator-Mediated Cleavage and Delayed Human Prostate Bone Metastasis
- (2009) M. O. Ports et al. CANCER RESEARCH
- Integrins
- (2009) Malgorzata Barczyk et al. CELL AND TISSUE RESEARCH
- Modulation of prostate cancer cell gene expression by cell-to-cell contact with bone marrow stromal cells or osteoblasts
- (2009) Shuming Zhang et al. CLINICAL & EXPERIMENTAL METASTASIS
- Small Integrin-Binding Proteins as Serum Markers for Prostate Cancer Detection
- (2009) A. Jain et al. CLINICAL CANCER RESEARCH
- Function and Antagonism of β Integrins in the Development of Cancer Therapy
- (2009) H. Sheldrake et al. CURRENT CANCER DRUG TARGETS
- The role of integrin α8β1 in fetal lung morphogenesis and injury
- (2009) John T. Benjamin et al. DEVELOPMENTAL BIOLOGY
- αvβ5/β6 integrin suppression leads to a stimulation of α2β1 dependent cell migration resistant to PI3K/Akt inhibition
- (2009) Céline Defilles et al. EXPERIMENTAL CELL RESEARCH
- Molecular Basis of the Recognition of Nephronectin by Integrin α8β1
- (2009) Yuya Sato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment
- (2009) Jian-Ping Xiong et al. JOURNAL OF CELL BIOLOGY
- Prostate cancer regulatory networks
- (2009) Dario C. Altieri et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Bone sialoprotein stimulates focal adhesion-related signaling pathways: Role in migration and survival of breast and prostate cancer cells
- (2009) Jonathan A.R. Gordon et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Small-Animal PET of Tumors with 64Cu-Labeled RGD-Bombesin Heterodimer
- (2009) Z. Liu et al. JOURNAL OF NUCLEAR MEDICINE
- Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery
- (2009) Mark P. Borgman et al. MOLECULAR PHARMACEUTICS
- Will integrin inhibitors have proangiogenic effects in the clinic?
- (2009) Michael Weller et al. NATURE MEDICINE
- Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
- (2009) Andrew R Reynolds et al. NATURE MEDICINE
- Targetable HPMA Copolymer–Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy
- (2009) Mark P. Borgman et al. PHARMACEUTICAL RESEARCH
- The Integrin Antagonist Cilengitide Activates αVβ3, Disrupts VE-Cadherin Localization at Cell Junctions and Enhances Permeability in Endothelial Cells
- (2009) Gian Carlo Alghisi et al. PLoS One
- PR_b-targeted delivery of tumor necrosis factor-α by polymersomes for the treatment of prostate cancer
- (2009) Döne Demirgöz et al. Soft Matter
- Integrins
- (2008) Rita Silva et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Reduced growth and integrin expression of prostate cells cultured with lycopene, vitamin E and fish oil in vitro
- (2008) T. Bureyko et al. BRITISH JOURNAL OF NUTRITION
- Prostaglandin E2 Regulates Tumor Angiogenesis in Prostate Cancer
- (2008) S. Jain et al. CANCER RESEARCH
- Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth
- (2008) F. Donate et al. CLINICAL CANCER RESEARCH
- Integrins in prostate cancer progression
- (2008) H. L. Goel et al. ENDOCRINE-RELATED CANCER
- Cilengitide: an integrin-targeting arginine–glycine–aspartic acid peptide with promising activity for glioblastoma multiforme
- (2008) David A Reardon et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Platelet-derived microparticles promote invasiveness of prostate cancer cellsviaupregulation of MMP-2 production
- (2008) Olga Dashevsky et al. INTERNATIONAL JOURNAL OF CANCER
- Snail Regulates Cell-Matrix Adhesion by Regulation of the Expression of Integrins and Basement Membrane Proteins
- (2008) Misako Haraguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Invadopodia and Matrix Degradation, a New Property of Prostate Cancer Cells during Migration and Invasion
- (2008) Bhavik Desai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the v 5 and 5 1 integrins
- (2008) D. Vial et al. JOURNAL OF CELL SCIENCE
- Dual Integrin and Gastrin-Releasing Peptide Receptor Targeted Tumor Imaging Using18F-labeled PEGylated RGD-Bombesin Heterodimer18F-FB-PEG3-Glu-RGD-BBN
- (2008) Zhaofei Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- 18F-Labeled BBN-RGD Heterodimer for Prostate Cancer Imaging
- (2008) Z.-B. Li et al. JOURNAL OF NUCLEAR MEDICINE
- PR_b-Targeted PEGylated Liposomes for Prostate Cancer Therapy
- (2008) Döne Demirgöz et al. LANGMUIR
- The Role of Alpha 6 Integrin in Prostate Cancer Migration and Bone Pain in a Novel Xenograft Model
- (2008) Tamara E. King et al. PLoS One
- Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins
- (2008) Tzu-Hsiu Lai et al. PROSTATE
- Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation
- (2008) Tao Wang et al. PROSTATE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started