Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

(2016) Amiya Kumar Ghosh et al.   Aging-US

Atg7cooperates withPtenloss to drive prostate cancer tumor growth

(2016) Urmila Santanam et al.   GENES & DEVELOPMENT

Col2-Cre and tamoxifen-inducible Col2-CreER target different cell populations in the knee joint

(2016) M. Nagao et al.   OSTEOARTHRITIS AND CARTILAGE

FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia

(2015) Xiaofeng Wang et al.   Autophagy

Endoplasmic reticulum stress-mediated autophagy contributes to bluetongue virus infection via the PERK-eIF2α pathway

(2015) Shuang Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation

(2015) Karuna K Vuppalapati et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGF signalling regulates bone growth through autophagy

(2015) Laura Cinque et al.   NATURE

Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

(2015) C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

(2015) Trevor L. Cameron et al.   PLoS Genetics

Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR

(2014) Scott A. Houck et al.   MOLECULAR CELL

Boning up on autophagy

(2013) Irving M Shapiro et al.   Autophagy

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CCAAT/Enhancer-binding Protein β Regulates the Repression of Type II Collagen Expression during the Differentiation from Proliferative to Hypertrophic Chondrocytes

(2013) Takahiro Ushijima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation

(2013) L. P. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress

(2013) Faith Hall-Glenn et al.   Journal of Cell Communication and Signaling

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Skeletal Morphogenesis during Embryonic Development

(2012) Yingzi Yang   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Autophagy: A new player in skeletal maintenance?

(2012) Lynne J Hocking et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

(2011) Takahide Tohmonda et al.   EMBO REPORTS

Induction and patterning of intramembranous bone

(2011) Tamara et al.   Frontiers in Bioscience-Landmark

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

Modulating stress responses by the UPRosome: A matter of life and death

(2011) Ute Woehlbier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

(2010) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GADD45β EnhancesCol10a1Transcription via the MTK1/MKK3/6/p38 Axis and Activation of C/EBPβ-TAD4 in Terminally Differentiating Chondrocytes

(2010) Kaneyuki Tsuchimochi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation-of-autophagy pathway may influence Chinese stature variation: evidence from elder adults

(2010) Feng Pan et al.   JOURNAL OF HUMAN GENETICS

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Self-eating in skeletal development: Implications for lysosomal storage disorders

(2009) Carmine Settembre et al.   Autophagy

Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection

(2009) Yoshihito Ishida et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

(2009) Atsushi Saito et al.   NATURE CELL BIOLOGY

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

(2009) Tomohiko Murakami et al.   NATURE CELL BIOLOGY

C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

(2009) Makoto Hirata et al.   PLoS One

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification

(2008) C. Settembre et al.   GENES & DEVELOPMENT

About the importance of being desulfated

(2008) R. Khatri et al.   GENES & DEVELOPMENT

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION