Label-free NMR-based dissociation kinetics determination

Measurement of Ligand–Target Residence Times by 1H Relaxation Dispersion NMR Spectroscopy

(2016) Thomas Moschen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative and predictive model of kinetic regulation byE. coliTPP riboswitches

(2016) Sondés Guedich et al.   RNA Biology

The Role of Target Binding Kinetics in Drug Discovery

(2015) Dong Guo et al.   ChemMedChem

Multiple conformational states of riboswitches fine-tune gene regulation

(2015) Boris Fürtig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Biochemical characterization of smoothened receptor antagonists by binding kinetics against drug-resistant mutant

(2015) Yuji Shimizu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Assessment of chemical exchange in tryptophan–albumin solution through 19F multicomponent transverse relaxation dispersion analysis

(2015) Ping-Chang Lin   JOURNAL OF BIOMOLECULAR NMR

An excess of catalytically required motions inhibits the scavenger decapping enzyme

(2015) Ancilla Neu et al.   Nature Chemical Biology

The drug–target residence time model: a 10-year retrospective

(2015) Robert A. Copeland   NATURE REVIEWS DRUG DISCOVERY

Ligand deconstruction: Why some fragment binding positions are conserved and others are not

(2015) Dima Kozakov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

(2014) Angeles Canales et al.   ACS Chemical Biology

Population Shuffling of Protein Conformations

(2014) Colin A. Smith et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Energetic dissection of Gleevec's selectivity toward human tyrosine kinases

(2014) Roman V Agafonov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clozapine, a Fast-Off-D2 Antipsychotic

(2013) Philip Seeman   ACS Chemical Neuroscience

Kinetics of Ligand-Receptor Interaction Reveals an Induced-Fit Mode of Binding in a Cyclic Nucleotide-Activated Protein

(2013) Sebastian Peuker et al.   BIOPHYSICAL JOURNAL

Molecular determinants of drug–receptor binding kinetics

(2013) Albert C. Pan et al.   DRUG DISCOVERY TODAY

Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists

(2013) Maris Vilums et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measuring Dynamic and Kinetic Information in the Previously Inaccessible Supra-tc Window of Nanoseconds to Microseconds by Solution NMR Spectroscopy

(2013) David Ban et al.   MOLECULES

Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time

(2012) Dong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exceeding the limit of dynamics studies on biomolecules using high spin-lock field strengths with a cryogenically cooled probehead

(2012) David Ban et al.   JOURNAL OF MAGNETIC RESONANCE

Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism

(2012) Georges Vauquelin et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

An introduction to NMR-based approaches for measuring protein dynamics

(2010) Ian R. Kleckner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Toward Flexibility−Activity Relationships by NMR Spectroscopy: Dynamics of Pin1 Ligands

(2010) Andrew T. Namanja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping the dynamics of ligand reorganization via 13CH3 and 13CH2 relaxation dispersion at natural abundance

(2009) Jeffrey W. Peng et al.   JOURNAL OF BIOMOLECULAR NMR

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

(2008) Ole A. Andersen et al.   CHEMISTRY & BIOLOGY

Designing transient binding drugs: A new concept for drug discovery

(2008) Sten Ohlson   DRUG DISCOVERY TODAY

Dynamics of Ligand Binding from13C NMR Relaxation Dispersion at Natural Abundance

(2008) John S. Zintsmaster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY