Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease

Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain

(2016) Steven M. Chirieleison et al.   JOURNAL OF IMMUNOLOGY

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency

(2015) Magdalena Dziadzio et al.   JOURNAL OF CLINICAL IMMUNOLOGY

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice

(2014) W.-C. Hsieh et al.   BLOOD

XIAP variants in male Crohn's disease

(2014) Yvonne Zeissig et al.   GUT

Characterization of Crohn disease in X-linked inhibitor of apoptosis–deficient male patients and female symptomatic carriers

(2014) Claire Aguilar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In VivoInhibition of RIPK2 Kinase Alleviates Inflammatory Disease

(2014) Justine T. Tigno-Aranjuez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

(2014) J. G. Magalhaes et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Successful treatment of idiopathic colitis related to XIAP deficiency with allo-HSCT using reduced-intensity conditioning

(2014) Yusuke Tsuma et al.   PEDIATRIC TRANSPLANTATION

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

(2013) C. Speckmann et al.   CLINICAL IMMUNOLOGY

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling

(2013) Xing Huang et al.   EMBO JOURNAL

Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

(2013) Rune Busk Damgaard et al.   EMBO Molecular Medicine

Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease

(2012) Justine T. Tigno-Aranjuez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

(2012) R. A. Marsh et al.   BLOOD

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

(2012) John A. Flygare et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

(2011) Patrick J. Shaw et al.   IMMUNITY

A new category of autoinflammatory disease associated with NOD2 gene mutations

(2011) Qingping Yao et al.   ARTHRITIS RESEARCH & THERAPY

XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection

(2011) Laura D. Bauler et al.   PLoS Pathogens

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

(2010) R. A. Marsh et al.   BLOOD

Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

(2010) Elizabeth A Worthey et al.   GENETICS IN MEDICINE

Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation

(2010) Wei Duan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficiency of XIAP Leads to Sensitization forChlamydophila pneumoniaePulmonary Infection and Dysregulation of Innate Immune Response in Mice

(2010) Hridayesh Prakash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Copper Chaperone CCS by XIAP-Mediated Ubiquitination

(2010) G. F. Brady et al.   MOLECULAR AND CELLULAR BIOLOGY

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

A rapid flow cytometric screening test for X-linked lymphoproliferative disease due to XIAP deficiency

(2009) Rebecca A. Marsh et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Analyses of associations with asthma in four asthma population samples from Canada and Australia

(2009) Denise Daley et al.   HUMAN GENETICS

Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohnʼs disease

(2009) Anna Negroni et al.   INFLAMMATORY BOWEL DISEASES

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

(2008) Mads Gyrd-Hansen et al.   NATURE CELL BIOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology