Review
Allergy
Alison G. Stanbery, Shuchi Smita, Jakob von Moltke, Elia D. Tait Wojno, Steven F. Ziegler
Summary: The release of cytokines from epithelial and stromal cells plays a critical role in tissue immunity, with thymic stromal lymphopoietin, IL-33, and IL-25 being important regulators of type 2 immune responses. These tissue-associated cytokines not only contribute to canonical type 2 responses but also play roles in viral infections, cancer, and homeostasis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Sofia Tagkareli, Maria Salagianni, Ioanna-Evdokia Galani, Maria Manioudaki, Eleftherios Pavlos, Kalliopi Thanopoulou, Evangelos Andreakos
Summary: The study identified a novel regulatory T-cell population expressing CD103, which is programmed to prevent excessive type 2 inflammation and maintain homeostasis in the respiratory tract. This has important therapeutic implications for allergic and autoimmune disorders.
Article
Allergy
Donald T. Gracias, Gurupreet S. Sethi, Amit K. Mehta, Haruka Miki, Rinkesh K. Gupta, Hideo Yagita, Michael Croft
Summary: The study found that memory T-cell responses to complex allergens are controlled by several TNF costimulatory interactions, and targeting these molecules in combination may represent a strategy to reduce the severity of inflammatory reactions following reexposure to allergen.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Kan Zhang, Yuchen Feng, Yuxia Liang, Wenliang Wu, Chenli Chang, Dian Chen, Shengchong Chen, Jiali Gao, Gongqi Chen, Lingling Yi, Dan Cheng, Guohua Zhen
Summary: In type 2-high asthma patients, miR-206 was identified as the most highly expressed epithelial microRNA, targeting the CD39-extracellular ATP axis to upregulate airway IL-5 and TSLP expression, forming a feedback loop to eliminate excessive ATP. Antagonism of airway miR-206 can alleviate type 2 inflammation.
Article
Oncology
Qingshan Ji, Jiajia Liu, Yiran Dong, Lisong Wang, Kai Dong, Berthold Setiz, Nora Szentmary, Bin Qu, Lei Shi
Summary: This study demonstrates that TSLP regulates the differentiation of Th17 and Treg cells by controlling miR-21 and Smad7, revealing the biological role of miR-21 in fungal keratitis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Dermatology
Yugang Gong, Li Luo, Ling Li, Xun He, Wei Lu, Xiaowei Sha, Yujie Mao
Summary: The TSLP/OX40L/IL-13 pathway was found to be down-regulated in some severe AA patients, and DPCP treatment might have a therapeutic role by up-regulating this pathway in responders. This pathway could serve as a predictor of response to DPCP therapy for severe AA patients.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Prabhakaran Kumar, Sivasangari Balakrishnan, Swarali Surendra Lele, Suman Setty, Shaurya Dhingra, Alan L. Epstein, Bellur S. Prabhakar
Summary: T follicular regulatory (TFR) cells, which are specialized in suppressing germinal center (GC) B cell response, play an important role in lupus nephritis (LN). In this study, the researchers found a reduction in TFR cells and decreased TFR/TFH ratio in NZBWF1/j mice, which correlated with increased GC-B cells and proteinuria onset in LN. Treatment with soluble OX40L and Jagged-1 (JAG1) proteins increased TFR cells and TFR/TFH ratio, and reduced TFH cells, GC B cells, and anti-dsDNA IgG antibody levels, leading to suppression of LN onset. Mechanistic studies showed inhibited TFH functions and diminished GC events in treated mice. RNA sequencing studies revealed inhibition of HIF-1 alpha and STAT3 signaling in T cells from treated mice. Overall, the increased TFR/TFH ratio and restoration of homeostatic balance suppressed LN pathogenesis.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biology
Julie Y. Zhou, Carlos A. Alvarez, Brian A. Cobb
Summary: Cells integrate concurrent signaling initiated by different cytokines to produce specific responses, and the combinatorial effects of different cytokines can lead to distinct biological outcomes, understanding this signaling pathway is crucial for addressing diseases.
Article
Allergy
Mehdi Benamar, Hani Harb, Qian Chen, Muyun Wang, Tsz Man Fion Chan, Jason Fong, Wanda Phipatanakul, Amparito Cunningham, Deniz Ertem, Carter R. Petty, Amirhosein J. Mousavi, Constantinos Sioutas, Elena Crestani, Talal A. Chatila
Summary: The interaction between IL-4R alpha R576 and Notch4 promotes asthmatic inflammation. Asthmatics carrying the IL4R(R576) allele have increased Notch4 expression on their T-reg cells. Mice harboring the Il4ra(R576) allele exhibit increased Notch4-dependent allergic airway inflammation.
Article
Biochemistry & Molecular Biology
Juan Jin, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Chang Ho Song, So-Yong Lee, Hee Soon Shin, Ok Hee Chai
Summary: This study found that Fallopia japonica root extract (FJE) has therapeutic effects on airway inflammation associated with allergic rhinitis and asthma. It reduces the production of inflammatory cells and pro-inflammatory cytokines, improves histopathological characteristics, and modulates the IL-33/TSLP/NF-B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Risa Ebina-Shibuya, Erin E. West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B. McGavern, Warren J. Leonard
Summary: TSLP plays a crucial role in the development of diseases such as asthma, atopic dermatitis, and allergic inflammation, but its role in CD8(+) T-cell primary responses and memory CD8(+) T cell responses to secondary viral infection is still controversial. Research has shown that TSLP limits the primary CD8(+) T-cell response to influenza, but has little effect on T cell function and the number of memory CD8(+) T cells generated after influenza infection, while inhibiting memory CD8(+) T-cell responses to secondary viral infections.
Review
Allergy
Julia Borowczyk, Maria Shutova, Nicolo Costantino Brembilla, Wolf-Henning Boehncke
Summary: IL-25, a unique cytokine of the IL-17 family, predominantly derived from epithelial cells, plays a significant role in various organ systems' physiology and pathology. It may lead to inflammatory disorders and helps maintain the balance in regulating immune responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Panpan Fan, Zhi Liu, Mei Zheng, Ming Chen, Yueshi Xu, Dongchi Zhao
Summary: The study reveals that RSV NS1 protein disrupts immune tolerance and induces airway inflammation and hyperreactivity in mice. NS1-stimulated TSLP and OX40L play a major role in inhibiting the induction of Tregs, which is partially mediated through modulating the AKT-mTOR signaling pathways.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Sihan Liu, Yanxia Fu, Kunrong Mei, Yinan Jiang, Xiaojun Sun, Yinyin Wang, Fangli Ren, Congshan Jiang, Liesu Meng, Shemin Lu, Zhihai Qin, Chen Dong, Xinquan Wang, Zhijie Chang, Shigao Yang
Summary: The study found that in rheumatoid arthritis, soluble glycosylated interleukin-17 receptor D (sIL-17RD) exacerbates the disease by enhancing the proinflammatory response induced by TNF-alpha. The shedding of IL-17RD is regulated by the proteolytic enzyme TACE and is enhanced by TNF-alpha expression in macrophages, suggesting it may be a new target for the therapy of RA.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Siyuan Wan, Lu Ni, Xiaohong Zhao, Xindong Liu, Wei Xu, Wei Jin, Xiaohu Wang, Chen Dong
Summary: The study revealed that PMA + ionomycin stimulation combined with IL-6 can induce Tfh cell-like transcriptomic programs in vitro, and inhibition of ERK2 can enhance Tfh cell development. Additionally, ICOS lacks the ability to activate ERK, while Zfp831 promotes Tfh cell differentiation by upregulating the expression of Bcl6 and Tcf7.
Article
Infectious Diseases
Gui-Ling Chen, Xiao-Feng Li, Xia-Hong Dai, Nan Li, Meng-Li Cheng, Zhen Huang, Jian Shen, Yu-Hua Ge, Zhen-Wei Shen, Yong-Qiang Deng, Shu-Yuan Yang, Hui Zhao, Na-Na Zhang, Yi-Fei Zhang, Ling Wei, Kai-Qi Wu, Meng-Fei Zhu, Cong-Gao Peng, Qi Jiang, Shou-Chun Cao, Yu-Hua Li, Dan-Hua Zhao, Xiao-Hong Wu, Ling Ni, Hua-Hao Shen, Chen Dong, Bo Ying, Guo-Ping Sheng, Cheng-Feng Qin, Hai-Nv Gao, Lan-Juan Li
Summary: This study evaluated the preliminary safety, tolerability, and immunogenicity of an mRNA vaccine (ARCoV) encoding the receptor-binding domain of the SARS-CoV-2 spike protein. The results showed that ARCoV was safe and well-tolerated at all doses and induced strong humoral and cellular immune responses. These findings support further clinical testing of ARCoV on a large scale.
Editorial Material
Medicine, General & Internal
Xin Wu, Huji Xu, Chen Dong
CHINESE MEDICAL JOURNAL
(2022)
Article
Biology
Han Feng, Xiaohong Zhao, Jenny Xie, Xue Bai, Weiwei Fu, Hairong Chen, Hong Tang, Xiaohu Wang, Chen Dong
Summary: This study systematically compared the transcriptomic profiles of Tfh cells from different types of immune responses and found differential induction of gene clusters corresponding to effector Th cells. It also discovered a subset of Tfh cells producing IFN-gamma in influenza virus infection, which had a unique developmental regulation. Selective ablation of these cells impaired immune response and control of infection.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Editorial Material
Biology
Xinyi Guo, Chen Dong
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Shanjuan Hong, Qing Yuan, Haizhui Xia, Yuan Dou, Tiantian Sun, Tian Xie, Zhiyin Zhang, Wei He, Chen Dong, Jian Lu, Li Guo, Ling Ni
Summary: This study established an ex vivo cultured tumor tissue model to evaluate the efficacy of a VISTA inhibitor in treating clear cell renal cell carcinoma (ccRCC). The results showed that all tested patients responded to the anti-VISTA antibody, while only a small fraction responded to the anti-PD-1 antibody. Co-blockade of VISTA and PD-1 had a synergistic effect in 20% of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinwei Liu, Jing Hao, Peng Wei, Xiaohong Zhao, Qiuyan Lan, Lu Ni, Yongzhen Chen, Xue Bai, Ling Ni, Chen Dong
Summary: In this study, the researchers found that SMAD4 plays a critical role in promoting CD8(+) T cell function in both tumor and infection models. SMAD4-mediated transcriptional regulation enhances CD8(+) T cell activation and cytotoxicity through the T cell receptor (TCR) signaling pathway. Furthermore, SMAD4 is directly phosphorylated by ERK following TCR activation.
Review
Allergy
Han Feng, Zixuan Zhao, Chen Dong
Summary: This article reviews the plasticity of T-FH cells in various types of immune responses and highlights their important implications in understanding and treating human diseases, particularly allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xinhui Ni, Yi Xu, Wang Wang, Baida Kong, Jian Ouyang, Jiwei Chen, Man Yan, Yawei Wu, Qi Chen, Xinxin Wang, Hongquan Li, Xiaoguang Gao, Hongquan Guo, Lian Cui, Zeyu Chen, Yuling Shi, Ronghui Zhu, Wei Li, Tieliu Shi, Lin-Fa Wang, Jinling Huang, Chen Dong, Yuping Lai
Summary: This study found that the RNA helicase DDX5 plays an important role in inflammatory skin disorders. DDX5 expression was downregulated in keratinocytes from patients with atopic dermatitis and psoriasis. Mice with keratinocyte-specific deletion of DDX5 were more susceptible to cutaneous inflammation. Inhibition of DDX5 led to pre-messenger RNA splicing events that favored the production of membrane-bound IL-36 receptor and selective amplification of IL-36R-mediated inflammatory responses and cutaneous inflammation.
Article
Multidisciplinary Sciences
Xinxin Chi, Wei Jin, Xiaohong Zhao, Tian Xie, Jing Shao, Xue Bai, Yu Jiang, Xiaohu Wang, Chen Dong
Summary: This study reveals the dual crucial functions of RORγt in effector T(H)17 cells, maintaining the T(H)17 cell program and constraining the conversion to T(H)2 cells. The loss of RORγt leads to closed chromatin configuration and inhibits Il4 transcription. These findings provide previously unidentified considerations in therapeutic targeting of RORγt.
Article
Immunology
Qinli Sun, Xiaohong Zhao, Ruifeng Li, Dingfeng Liu, Birui Pan, Bowen Xie, Xinxin Chi, Dongli Cai, Peng Wei, Wei Xu, Kun Wei, Zixuan Zhao, Yujie Fu, Ling Ni, Chen Dong
Summary: Sun et al. discovered that STAT3, activated by IL-10 and IL-21, plays crucial roles in the terminal differentiation of effector CD8(+) T cells in cancer and acute infection. STAT3 enhances effector functions and survival of T-ex(term) cells in the tumor microenvironment, leading to improved tumor control. It transcriptionally promotes effector function-related genes and collaborates with BATF and IRF4 to mediate chromatin activation at effector gene loci.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Yuling Li, Jing Ge, Xiaohong Zhao, Miao Xu, Mengting Gou, Bowen Xie, Jinling Huang, Qinli Sun, Lin Sun, Xue Bai, Sangnee Tan, Xiaohu Wang, Chen Dong
Summary: Yuling Li et al. found that BCL6 is selectively expressed in CCR6(+) ILC3 among the ILC family. BCL6 expression, induced by intestinal microbiota, restrains the effector function and plasticity of CCR6(+) ILC3.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, LuLin Jiang, Tiantian Guo, Mingyu Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fanwei Zeng, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhiping Zeng, Timothy Y. Huang, Chen Dong, Hong Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Weihon Song, Xin Wang
Summary: Down syndrome is one of the critical risk factors for early-onset Alzheimer's disease, and the DS-related gene USP25 has been identified as a critical regulator of AD pathology, potentially serving as a pharmacological target for AD drug development.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Immunology
Pornpimon Angkasekwinai, Chen Dong
Summary: IL-9-producing CD4(+)T cells are considered a unique subset of T helper cells, closely related to T(H)2 cells and potentially playing important roles in allergic diseases and cancer. Research suggests that these cells may have strong potential in treating late-stage tumors such as melanomas.
NATURE REVIEWS IMMUNOLOGY
(2021)