期刊
FEBS LETTERS
卷 589, 期 12, 页码 1283-1295出版社
WILEY
DOI: 10.1016/j.febslet.2015.04.007
关键词
Cation Diffusion Facilitator; Membrane protein; Zinc transporter; Maricaulis maris
资金
- Irish Research Council for Science, Engineering and Technology (IRCSET)
The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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