Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity
出版年份 2017 全文链接
标题
Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 24, Pages 10197-10219
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2017-04-27
DOI
10.1074/jbc.m117.788919
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Insights into the activity of maturation inhibitor PF-46396 on HIV-1 clade C
- (2017) Dibya Ghimire et al. Scientific Reports
- Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G
- (2016) Guillaume B.E. Stewart-Jones et al. CELL
- Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
- (2016) Bryan Briney et al. CELL
- Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
- (2016) Ming Tian et al. CELL
- HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
- (2016) Jon M. Steichen et al. IMMUNITY
- Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site
- (2016) Constantinos Kurt Wibmer et al. JOURNAL OF VIROLOGY
- Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer
- (2016) J. H. Lee et al. SCIENCE
- Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
- (2016) D. Sok et al. SCIENCE
- HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
- (2016) J. G. Jardine et al. SCIENCE
- Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein
- (2016) Anna-Janina Behrens et al. Cell Reports
- Identification of potent maturation inhibitors against HIV-1 clade C
- (2016) Uddhav Timilsina et al. Scientific Reports
- Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice
- (2015) Pia Dosenovic et al. CELL
- Bottlenecks in HIV-1 transmission: insights from the study of founder viruses
- (2015) Sarah B. Joseph et al. NATURE REVIEWS MICROBIOLOGY
- Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
- (2015) J. G. Jardine et al. SCIENCE
- Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies
- (2015) Laura K. Pritchard et al. Nature Communications
- HIV broadly neutralizing antibody targets
- (2015) Constantinos Kurt Wibmer et al. Current Opinion in HIV and AIDS
- A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo
- (2015) Natalia T. Freund et al. PLoS Pathogens
- Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate
- (2015) Elizabeth Stansell et al. PLoS One
- Immunogen design for HIV-1 and influenza
- (2014) Ujjwal Rathore et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
- (2014) Emilia Falkowska et al. IMMUNITY
- Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
- (2014) Claudia Blattner et al. IMMUNITY
- Stabilizing the Native Trimer of HIV-1 Env by Destabilizing the Heterodimeric Interface of the gp41 Postfusion Six-Helix Bundle
- (2014) S. Kesavardhana et al. JOURNAL OF VIROLOGY
- Structure and immune recognition of trimeric pre-fusion HIV-1 Env
- (2014) Marie Pancera et al. NATURE
- Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike
- (2014) Louise Scharf et al. Cell Reports
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
- (2013) Florian Klein et al. CELL
- Design of anEscherichia coliExpressed HIV-1 gp120 Fragment Immunogen That Binds to b12 and Induces Broad and Potent Neutralizing Antibodies
- (2013) Sanchari Bhattacharyya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
- (2013) Andrew T. McGuire et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins
- (2013) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design
- (2013) L.-H. Ping et al. JOURNAL OF VIROLOGY
- HIV: Roadmaps to a vaccine
- (2013) Hugo Mouquet et al. NATURE
- Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
- (2013) Hua-Xin Liao et al. NATURE
- Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16
- (2013) Marie Pancera et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody
- (2013) L. Scharf et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of prophylactic vaccines against HIV-1
- (2013) Torben Schiffner et al. Retrovirology
- A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization
- (2013) Wenbo Wang et al. Retrovirology
- HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity
- (2013) Tom L G M van den Kerkhof et al. Retrovirology
- Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
- (2013) J.-P. Julien et al. SCIENCE
- Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
- (2013) D. Lyumkis et al. SCIENCE
- Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
- (2013) J. Jardine et al. SCIENCE
- The Antibody Response against HIV-1
- (2013) J. Overbaugh et al. Cold Spring Harbor Perspectives in Medicine
- Advances in structure-based vaccine design
- (2013) Daniel W Kulp et al. Current Opinion in Virology
- Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs
- (2013) Sam Hoot et al. PLoS Pathogens
- Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast
- (2012) Jordi Mata-Fink et al. JOURNAL OF MOLECULAR BIOLOGY
- Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape
- (2012) Penny L Moore et al. NATURE MEDICINE
- Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
- (2012) Anthony P. West et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broadly neutralizing antibodies against HIV-1: Templates for a vaccine
- (2012) Marit J. van Gils et al. VIROLOGY
- Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1
- (2011) Piyali Saha et al. BIOCHEMISTRY
- An efficient algorithmic approach for mass spectrometry-based disulfide connectivity determination using multi-ion analysis
- (2011) William Murad et al. BMC BIOINFORMATICS
- Mechanisms and principles of N-linked protein glycosylation
- (2011) Flavio Schwarz et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Characterization of Glycosylation Profiles of HIV-1 Transmitted/Founder Envelopes by Mass Spectrometry
- (2011) E. P. Go et al. JOURNAL OF VIROLOGY
- Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
- (2011) Jason S. McLellan et al. NATURE
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
- (2011) X. Wu et al. SCIENCE
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
- (2011) J. F. Scheid et al. SCIENCE
- A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
- (2011) R. Pejchal et al. SCIENCE
- Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction
- (2011) Xin Huang et al. VIROLOGY
- Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies
- (2011) Ben-Jiang Ma et al. PLoS Pathogens
- The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission
- (2011) Fatima Nawaz et al. PLoS Pathogens
- Design of a Non-glycosylated Outer Domain-derived HIV-1 gp120 Immunogen That Binds to CD4 and Induces Neutralizing Antibodies
- (2010) Sanchari Bhattacharyya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1
- (2010) M. Pancera et al. JOURNAL OF VIROLOGY
- In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1
- (2010) D. P. Leaman et al. JOURNAL OF VIROLOGY
- Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16
- (2010) Katie J. Doores et al. JOURNAL OF VIROLOGY
- Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization
- (2010) J. M. Binley et al. JOURNAL OF VIROLOGY
- Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level
- (2010) Evelien M Bunnik et al. NATURE MEDICINE
- Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
- (2010) Davide Corti et al. PLoS One
- Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
- (2010) R. Pejchal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-based engineering of a monoclonal antibody for improved solubility
- (2010) S.-J. Wu et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
- (2010) T. Zhou et al. SCIENCE
- The critical role of mobile phase composition in size exclusion chromatography of protein pharmaceuticals
- (2009) Tsutomu Arakawa et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Enzymatic assembly of DNA molecules up to several hundred kilobases
- (2009) Daniel G Gibson et al. NATURE METHODS
- The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability
- (2009) S. R. Hanson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycans on influenza hemagglutinin affect receptor binding and immune response
- (2009) C.-C. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
- (2009) L. Chen et al. SCIENCE
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Molecular architecture of native HIV-1 gp120 trimers
- (2008) Jun Liu et al. NATURE
- An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
- (2008) M. Onda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
- (2008) B. F. Keele et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Viral characteristics of transmitted HIV
- (2008) Cynthia A Derdeyn et al. Current Opinion in HIV and AIDS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started