期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1844, 期 11, 页码 1891-1906出版社
ELSEVIER
DOI: 10.1016/j.bbapap.2014.05.010
关键词
Vaccine; Protein minimization; Native trimer; Stability; Glycosylation
资金
- Council of Scientific and Industrial Research, Government of India
- Department of Biotechnology, Government of India [BT/PR4506/MED/107/1/2012 DTD 27.3.2012]
Vaccines provide the most cost effective defense against pathogens. Although vaccines have been designed for a number of viral diseases, a vaccine against HIV-1 still remains elusive. In contrast while there are excellent influenza vaccines, these need to be changed every few years because of antigenic drift and shift The recent discovery of a large number of broadly neutralizing antibodies (bNAbs) and structural characterization of the conserved epitopes targeted by them presents an opportunity for structure based HIV-1 and influenza A vaccine design. We discuss strategies to design immunogens either targeting a particular antigenic region or focusing on native structure stabilization. This article is part of a Special Issue entitled: Recent advances in molecular engineering of antibody. (C) 2014 Elsevier B.V. All rights reserved.
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