The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway

Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

(2016) Stine Jørgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

(2016) Xiao-Feng Xiong et al.   Nature Chemistry

Structural mechanism of ligand activation in human calcium-sensing receptor

(2016) Yong Geng et al.   eLife

Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

(2016) C. Zhang et al.   Science Advances

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants

(2016) Patricia Rueda et al.   PLoS One

N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization

(2015) Lenea Nørskov-Lauritsen et al.   FEBS LETTERS

Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold

(2015) Henrik Johansson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate

(2015) Angélique Levoye et al.   Frontiers in Endocrinology

Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking

(2014) Sarah Noerklit Roed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

(2013) Franck Oury et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

(2013) Christoffer Clemmensen et al.   JOURNAL OF ENDOCRINOLOGY

Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

(2013) Sarah Noerklit Roed et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Enhanced voluntary wheel running in GPRC6A receptor knockout mice

(2013) Christoffer Clemmensen et al.   PHYSIOLOGY & BEHAVIOR

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

(2012) Sanela Smajilovic et al.   AMINO ACIDS

Constitutive internalization and recycling of metabotropic glutamate receptor 5 (mGluR5)

(2012) Rishi Raj Trivedi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPRC6A Mediates the Effects ofl-Arginine on Insulin Secretion in Mouse Pancreatic Islets

(2012) Min Pi et al.   ENDOCRINOLOGY

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

Chemogenomic Discovery of Allosteric Antagonists at the GPRC6A Receptor

(2011) David E. Gloriam et al.   CHEMISTRY & BIOLOGY

Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level

(2011) Xiaolei Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

(2011) Min Pi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

GPRC6A regulates prostate cancer progression

(2011) Min Pi et al.   PROSTATE

Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude

(2011) M. P. Grant et al.   Science Signaling

GPRC6A Mediates the Non-genomic Effects of Steroids

(2010) Min Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis for amino acid sensing by family C G-protein-coupled receptors

(2009) P Wellendorph et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Availability of Surface GABABReceptors Is Independent of γ-Aminobutyric Acid but Controlled by Glutamate in Central Neurons

(2008) Karina J. Vargas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABAB receptors in cortical neurons

(2008) Thomas Grampp et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome

(2008) Min Pi et al.   PLoS One