Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
出版年份 2017 全文链接
标题
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
作者
关键词
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出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 9, Pages 3900-3908
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2017-01-12
DOI
10.1074/jbc.m116.767749
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions
- (2016) Tilman Schlothauer et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a
- (2015) E. Arduin et al. MOLECULAR IMMUNOLOGY
- Alternative molecular formats and therapeutic applications for bispecific antibodies
- (2015) Christoph Spiess et al. MOLECULAR IMMUNOLOGY
- Amgen's bispecific antibody puffs across finish line
- (2015) Cormac Sheridan NATURE BIOTECHNOLOGY
- Biopharmaceutical benchmarks 2014
- (2014) Gary Walsh NATURE BIOTECHNOLOGY
- Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
- (2014) Y. J. Yu et al. Science Translational Medicine
- Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys
- (2013) Maya K Leabman et al. mAbs
- Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity
- (2013) Whitney Shatz et al. mAbs
- Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
- (2013) Christoph Spiess et al. NATURE BIOTECHNOLOGY
- CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
- (2013) R. J. Brentjens et al. Science Translational Medicine
- Properties of mouse and human IgG receptors and their contribution to disease models
- (2012) P. Bruhns BLOOD
- Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1
- (2012) Thomas C. Nesspor et al. JOURNAL OF MOLECULAR RECOGNITION
- Marketed therapeutic antibodies compendium
- (2012) Janice M. Reichert mAbs
- With or Without Sugar? (A)glycosylation of Therapeutic Antibodies
- (2012) Dmitrij Hristodorov et al. MOLECULAR BIOTECHNOLOGY
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies
- (2010) Athena W. Wong et al. BIOTECHNOLOGY AND BIOENGINEERING
- Identification of IgG1 variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays
- (2010) Yanmei Lu et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors
- (2008) S. L. Sazinsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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