A mutant of theButhus martensiiKarsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity

The roles of conserved aromatic residues (Tyr5 and Tyr42) in interaction of scorpion toxin BmK AGP-SYPU1 with human Na v 1.7

(2017) Xiangxue Meng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Na V 1.7 as a pain target – From gene to pharmacology

(2017) Irina Vetter et al.   PHARMACOLOGY & THERAPEUTICS

Recombinant Expression, Functional Characterization of Two Scorpion Venom Toxins with Three Disulfide Bridges from the Chinese Scorpion Buthus martensii Karsch

(2017) Shengguo Lin et al.   PROTEIN AND PEPTIDE LETTERS

Parkinson’s disease-like forelimb akinesia induced by BmK I, a sodium channel modulator

(2016) Hongyan Zhu et al.   BEHAVIOURAL BRAIN RESEARCH

Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7

(2016) Rhiannon Thomas-Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans from β-Amyloid Toxicity

(2016) Xiao-Gang Zhang et al.   Frontiers in Pharmacology

Loss-of-function mutations inSCN4Acause severe foetal hypokinesia or ‘classical’ congenital myopathy

(2015) Irina T. Zaharieva et al.   BRAIN

Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution

(2015) Carlos E. Santibáñez-López et al.   TOXICON

Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus

(2015) Verónica Quintero-Hernández et al.   PLoS One

Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells

(2013) Jun Du et al.   BIOTECHNOLOGY LETTERS

Antinociceptive Effects of Analgesic-Antitumor Peptide (AGAP), a Neurotoxin from the Scorpion Buthus martensii Karsch, on Formalin-Induced Inflammatory Pain through a Mitogen-Activated Protein Kinases–Dependent Mechanism in Mice

(2013) Qinghong Mao et al.   PLoS One

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants of myocardial conduction velocity: implications for arrhythmogenesis

(2013) James H. King et al.   Frontiers in Physiology

Long-term efficacy of low doses of quinidine on malignant arrhythmias in Brugada syndrome with an implantable cardioverter-defibrillator: A case series and literature review

(2012) Manlio F. Márquez et al.   HEART RHYTHM

Expression and purification of an antitumor-analgesic peptide from the venom of Mesobuthus martensii Karsch by small ubiquitin-related modifier fusion in Escherichia coli

(2010) Peng Cao et al.   BIOTECHNOLOGY PROGRESS

Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1.1 mutations

(2010) Kristopher M Kahlig et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure and function relationship of toxin from Chinese scorpion Buthus martensii Karsch (BmKAGAP): Gaining insight into related sites of analgesic activity

(2010) Yong Cui et al.   PEPTIDES

Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy

(2008) R Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS