Review
Biochemistry & Molecular Biology
Rizwana Afroz, E. M. Tanvir, Mousumi Tania, Junjiang Fu, Mohammad Amjad Kamal, Md. Asaduzzaman Khan
Summary: This review article focuses on the role of toll-like receptors (TLRs), particularly TLR4, in breast cancer. TLRs are widely investigated pattern recognition receptors and TLR4 is the most studied TLR, associated with the development of various cancers, including breast cancer. Activation of TLR4 occurs through the binding of its ligand lipopolysaccharide (LPS), leading to gene expression related to cancer cell proliferation, survival, invasion, and metastasis. The role of TLR4 in breast cancer growth, invasion, and metastasis is attracting significant attention in oncology research, with potential for therapeutic applications.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Lu Xiao, Junyan Yan, Di Feng, Shasha Ye, Ting Yang, Hua Wei, Tingyu Li, Wuqing Sun, Jie Chen
Summary: Maternal LPS exposure increases TNF alpha and IL-6 levels in both maternal serum and fetal brains of WT mice, resulting in reduced litter size and weight in offspring. Activation of the TLR4 signaling pathway following maternal LPS exposure induces abnormal microglia activation in WT offspring, leading to excessive synaptic pruning and decreased synaptic plasticity, which may contribute to the development of autism-like behavior in offspring.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xueqing Hu, Wenqian Zhou, Shun Wu, Rui Wang, Zhiyong Luan, Xin Geng, Na Xu, Zhaoyong Zhang, Zhenmin Ruan, Zenghui Wang, Furong Li, Chen Yu, Hongqi Ren
Summary: The study revealed that tacrolimus has protective effects against LPS-induced SA-AKI by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and podocyte dysfunction, providing another potential therapeutic approach for LPS-induced SA-AKI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Review
Oncology
Mai Mahmoud Gabr, Iqira Saeed, Jared A. Miles, Benjamin P. Ross, Paul Nicholas Shaw, Markus W. Hollmann, Marie-Odile Parat
Summary: Recent evidence suggests that opioids can interact with the Toll-like receptor 4 (TLR4) on innate immune and cancer cells, potentially influencing tumor growth and metastasis. Opioids have been shown to weakly activate TLR4 and can inhibit its activation by lipopolysaccharide (LPS). The interaction of opioids with TLR4 is complex, involving non-competitive mechanisms and downstream effects on NF-kappa B activation.
Article
Cell Biology
Huizhen Wang, Yifan Wang, Xin Wang, Huimi Huang, Jingfu Bao, Wenhui Zhong, Aiqing Li
Summary: PTEN plays a crucial role in renal adaptive repair by upregulating CHMP2A to alleviate cell damage, apoptosis, and renal fibrosis. PTEN overexpression promotes phagosome closure, providing a potential therapeutic target for the transition from AKI to CKD.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Sara Francisco, Jean-Marc Billod, Javier Merino, Carmen Punzon, Alicia Gallego, Alicia Arranz, Sonsoles Martin-Santamaria, Manuel Fresno
Summary: This study reveals that Ochrobactrum intermedium LPS can activate both TLR4 and TLR2, indicating the occurrence of TLR4/TLR2 heterodimerization, and the core saccharide plays an important role in this interaction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Katharina Richard, Kurt H. Piepenbrink, Kari Ann Shirey, Archana Gopalakrishnan, Shreeram Nallar, Daniel J. Prantner, Darren J. Perkins, Wendy Lai, Alexandra Vlk, Vladimir Y. Toshchakov, Chiguang Feng, Rachel Fanaroff, Andrei E. Medvedev, Jorge C. G. Blanco, Stefanie N. Vogel
Summary: This study identified homologous substitutions of two SNPs in murine Tlr4, which are associated with human TLR4, using advanced protein modeling techniques. By creating a knock-in strain expressing these SNPs and studying their effects on TLR4 signaling, the research provided new insights into how these SNPs decrease TLR4 signaling efficiency and offered an experimental approach to validate or refute human data.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Swathy O. Vasudevan, Ashley J. Russo, Puja Kumari, Sivapriya Kailasan Vanaja, Vijay A. Rathinam
Summary: CD14 plays a vital role in intracellular LPS sensing by mediating the cytosolic localization of LPS, leading to the activation of caspase-11. This study provides evidence for the critical role of CD14 in noncanonical inflammasome sensing of LPS.
Article
Medicine, Research & Experimental
Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Kyeong Tae Lee, Mirissa Hewage Dumindu Kavinda, Seunghun Lee, Sanghyuck Kang, Mi-Hwa Lee, Chang -Hee Kang, Yung Hyun Choi, Gi-Young Kim
Summary: Pinostrobin, a natural flavonoid, has anti-inflammatory effects by binding to the TLR4/MD2 complex, attenuating LPS-induced inflammation and endotoxemia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Jian-Quan Luo, Huan Ren, Man-Yun Chen, Qing Zhao, Nian Yang, Qian Liu, Yong-Chao Gao, Hong-Hao Zhou, Wei-Hua Huang, Wei Zhang
Summary: Hydrochlorothiazide (HCTZ) impairs glucose tolerance and may induce new onset of diabetes through its interaction with the gut microbiome. HCTZ consumption disrupts the intestinal microbiota, leading to elevated levels of Gram-negative bacteria and lipopolysaccharide (LPS), which results in intestinal barrier dysfunction. Activation of TLR4 signaling by HCTZ further induces macrophage polarization, inflammation, and metabolic disorders in the liver. Blocking TLR4 signaling can alleviate HCTZ-induced macrophage polarization and metabolic disorders.
Article
Biochemistry & Molecular Biology
Yelin Tang, Wenxin Zhang, Liqin Wu, Bin Bai, Bin Zheng, Mengying Li, Yue Tang, Xiaona Zhu, Yali Zhang, Yi Wang, Bing Zhang
Summary: In this study, it was found that piperlongumine (PL) can alleviate LPS-induced acute lung injury (ALI) by inhibiting inflammatory response and directly influencing cytokine expression through the inhibition of the TAK1 and TBK1 pathways. PL may be a potential candidate for treating LPS-triggered ALI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Koji Ishida, Kosuke Kaji, Shinya Sato, Hiroyuki Ogawa, Hirotetsu Takagi, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Summary: Sulforaphane has a significant impact on acetaldehyde metabolism and liver fibrosis, alleviating alcoholic liver disease-related fibrosis by activating nuclear factor erythroid 2-related factor 2, and inhibiting the progression of chronic alcoholic liver disease.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Cell Biology
Anna Stierschneider, Benjamin Neuditschko, Katrin Colleselli, Harald Hundsberger, Franz Herzog, Christoph Wiesner
Summary: Optogenetic cell lines based on light-oxygen-voltage-sensing (LOV) domains (opto-TLR4-LOV LECs and opto-TLR4-LOV HUVECs) allow fast, precise, and reversible activation of TLR4 signaling pathways, providing a better simulation of inflammatory responses than LPS. Light-induced TLR4 activation can promote the expression of inflammatory proteins and significantly impact cell function and cell migration. This technology enables specific studies of TLR4.
Article
Genetics & Heredity
Qi Zhang, Jie Wang, Jin Zhang, Jie Wen, Guiping Zhao, Qinghe Li
Summary: The study used LPS from Escherichia coli serotype enteritidis to stimulate chicken macrophages and identified 1759 differentially expressed genes and 18 differentially expressed miRNAs. Following infection, at 6 hours, 1025 genes and 10 miRNAs were up-regulated, while 734 genes and 8 miRNAs were down-regulated.
Article
Immunology
Samira Mansouri, Seema Patel, Divya S. Katikaneni, Steven M. Blaauboer, Wei Wang, Stefan Schattgen, Katherine Fitzgerald, Lei Jin
MUCOSAL IMMUNOLOGY
(2019)
Article
Immunology
Michael Carty, Jay Kearney, Katharine A. Shanahan, Emily Hams, Ryoichi Sugisawa, Dympna Connolly, Ciara G. Doran, Natalia Munoz-Wolf, Claudia Gurtler, Katherine A. Fitzgerald, Ed C. Lavelle, Padraic G. Fallon, Andrew G. Bowie
Article
Multidisciplinary Sciences
Mona Motwani, Sudesh Pawaria, Jennifer Bernier, Stephanie Moses, Kate Henry, Terry Fang, Linda Burkly, Ann Marshak-Rothstein, Katherine A. Fitzgerald
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Shigao Yang, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, Katherine A. Fitzgerald, Gianna Hammer, Martin O. Bergo, Heather K. Kroh, D. Borden Lacy, Chunxiang Sun, Michael Glogauer, Loretta G. Que, Nicholas S. Heaton, Donghai Wang
Review
Genetics & Heredity
Mona Motwani, Scott Pesiridis, Katherine A. Fitzgerald
NATURE REVIEWS GENETICS
(2019)
Review
Immunology
Pontus Orning, Egil Lien, Katherine A. Fitzgerald
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Editorial Material
Immunology
Fiachra Humphries, Katherine A. Fitzgerald
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Fiachra Humphries, Katherine A. Fitzgerald
News Item
Genetics & Heredity
Fiachra Humphries, Katherine A. Fitzgerald
Article
Multidisciplinary Sciences
Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, Katherine A. Fitzgerald
NATURE COMMUNICATIONS
(2020)
Review
Rheumatology
Susan MacLauchlan, Katherine A. Fitzgerald, Ellen M. Gravallese
Summary: Evidence has shown that DNA plays a unique role in distinguishing between endogenous and foreign DNA, posing a challenge in disease discrimination. Autoinflammatory diseases resulting from gene mutations or DNA sensing pathway activation provide insight into the role of DNA in inflammation. This review discusses the current understanding of intracellular DNA sensing and its relevance to various diseases, as well as the development of therapies targeting these pathways.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Cell Biology
John S. S. Mattick, Paulo P. P. Amaral, Piero Carninci, Susan Carpenter, Howard Y. Y. Chang, Ling-Ling Chen, Runsheng Chen, Caroline Dean, Marcel E. E. Dinger, Katherine A. A. Fitzgerald, Thomas R. R. Gingeras, Mitchell Guttman, Tetsuro Hirose, Maite Huarte, Rory Johnson, Chandrasekhar Kanduri, Philipp Kapranov, Jeanne B. B. Lawrence, Jeannie T. T. Lee, Joshua T. T. Mendell, Timothy R. R. Mercer, Kathryn J. J. Moore, Shinichi Nakagawa, John L. L. Rinn, David L. L. Spector, Igor Ulitsky, Yue Wan, Jeremy E. E. Wilusz, Mian Wu
Summary: Genes encoding lncRNAs are abundant in complex organisms and are transcribed by RNA polymerase I, II, and III, as well as processed introns. The classification and annotation of lncRNAs are challenging due to their various functions, isoforms, and interactions with other genes. These lncRNAs evolve rapidly, are cell type-specific, and regulate multiple cellular processes, including gene expression and translation control.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Editorial Material
Immunology
Michelle A. Kelliher, Katherine A. Fitzgerald
Summary: Resistance mechanisms have hindered the effectiveness of immune checkpoint blockade therapies, but inhibition of TBK1 can restore their efficacy by sensitizing tumors to RIPK1 kinase-dependent cell death.
TRENDS IN IMMUNOLOGY
(2023)
Editorial Material
Cell Biology
Kevin MingJie Gao, Katherine A. Fitzgerald
Summary: Endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1L-HRD1 regulates steady-state STING levels to limit STING-driven inflammation, according to the study by Jie et al.
NATURE CELL BIOLOGY
(2023)
Article
Rheumatology
Jonathan J. J. Miner, Katherine A. A. Fitzgerald
Summary: Next-generation sequencing has revolutionized the field of genetics and has allowed for the discovery of rare autoinflammatory diseases and their corresponding mutations. This has opened up opportunities for personalized medicine and has shed light on more common forms of autoimmunity and autoinflammation. The rapid and cost-effective sequencing of individual genomes is changing the practice of rheumatology.
NATURE REVIEWS RHEUMATOLOGY
(2023)