Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

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Old Dogs, New Tricks: Monogenic Autoinflammatory Disease Unleashed

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Sodium-Calcium Exchanger and Multiple Sodium Channel Isoforms in Intra-Epidermal Nerve Terminals

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The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy

(2015) Chongyang Han et al.   NEUROMOLECULAR MEDICINE

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

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Phosphatidic acid modulation of Kv channel voltage sensor function

(2014) Richard K Hite et al.   eLife

Inherited Pain

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Noncanonical Roles of Voltage-Gated Sodium Channels

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High-Resolution Comparative Modeling with RosettaCM

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Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy

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Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation

(2012) Janneke G. J. Hoeijmakers et al.   BRAIN

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

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Nav1.7-related small fiber neuropathy: Impaired slow-inactivation and DRG neuron hyperexcitability

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Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

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Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

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Structural basis for gating charge movement in the voltage sensor of a sodium channel

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Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Effects of capsaicin-induced sensory denervation on bone metabolism in adult rats

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A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain

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Early- and late-onset inherited erythromelalgia: genotype–phenotype correlation

(2009) Chongyang Han et al.   BRAIN

Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling

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Voltage-clamp and current-clamp recordings from mammalian DRG neurons

(2009) Theodore R Cummins et al.   Nature Protocols

Voltage-Gated Sodium Channels: Therapeutic Targets for Pain

(2009) Sulayman D. Dib-Hajj et al.   PAIN MEDICINE

Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels

(2008) Yanping Xu et al.   NATURE