Article
Biochemistry & Molecular Biology
Hao Ruan, Jiaoyan Luan, Shaoyan Gao, Shuangling Li, Qiuyan Jiang, Rui Liu, Qing Liang, Ruiqin Zhang, Fangxia Zhang, Xiaohe Li, Honggang Zhou, Cheng Yang
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by excessive myofibrocyte aggregation and extracellular matrix deposition. Fedratinib (Fed) has been shown to inhibit inflammation and fibrosis processes induced by TGF-beta 1 and IL-6 by targeting the JAK2 receptor, improving lung function.
Article
Chemistry, Multidisciplinary
Yue-Jiao Lan, Ming-han Cheng, Hui-min Ji, Yu-qian Bi, Yong-yue Han, Chong-yang Yang, Xuan Gu, Jian Gao, Hong-liang Dong
Summary: Melatonin regulates the Fibroblast-myofibroblast differentiation (FMD) process by inhibiting the marker of oxidative stress, Galectin-3 (Gal-3), and effectively attenuates the progression of lung fibrosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medicine, Research & Experimental
Yong Mou, Juan Liu, Ting Pan, Qi Wang, Kang Miao, Yongjian Xu, Weining Xiong, Jun Yu
Summary: DA receptor agonists showed potential antifibrotic effects in IPF patients and mouse models by attenuating fibroblast differentiation and proliferation, protecting mice from pulmonary fibrosis induced by BLM.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Dongxin Chen, Huirong Tang, Hongchao Jiang, Lei Sun, Wenjuan Zhao, Feng Qian
Summary: This study investigated the effects of a selective CB1R agonist, ACPA, on pulmonary fibrosis induced by bleomycin (BLM). The results showed that ACPA treatment significantly improved survival rate and alleviated pulmonary fibrosis in BLM-treated mice. ACPA inhibited the expressions of extracellular matrix markers and diminished fibroblast migration triggered by TGF-beta. Furthermore, ACPA reduced the activation of TGF-beta-Smad2/3 signaling and decreased the expressions of downstream effector proteins in TGF-beta-challenged primary lung fibroblasts. These findings suggest that ACPA exhibits antifibrotic efficacy by targeting CB1R and inhibiting TGF-beta-Smad2/3 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Min Kyung Kim, Jong-Uk Lee, Sun Ju Lee, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Summary: Genetic and epigenetic factors have been identified in the development and prognosis of idiopathic pulmonary fibrosis (IPF). In this study, the role of erythrocyte membrane protein band 4.1-like 3 (EPB41L3) was investigated in IPF. It was found that EPB41L3 expression was significantly increased in lung fibroblasts from IPF patients compared to controls. The upregulation of EPB41L3 was also observed during epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
David M. Dolivo
Summary: Fibrosis is a pathological tissue repair process that leads to nearly half of deaths in developed countries. Current therapies targeting fibrosis are lacking, highlighting the significance of basic science research and anti-fibrotic modalities.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Aurelien Justet, Mada Ghanem, Tiara Boghanim, Mouna Hachem, Eirini Vasarmidi, Madeleine Jaillet, Aurelie Vadel, Audrey Joannes, Pierre Mordant, Philippe Bonniaud, Martin Kolb, Lei Ling, Aurelie Cazes, Herve Mal, Arnaud Mailleux, Bruno Crestani
Summary: This study identifies FGF19 as an antifibrotic molecule with potential therapeutic interest in fibrotic lung disorders. In vivo and in vitro experiments demonstrate that FGF19 can decrease lung fibrosis and fibrotic markers, modulate apoptosis of lung epithelial cells, and prevent myofibroblast differentiation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yun-hui Shen, Ming-han Cheng, Xin-yu Liu, De-wei Zhu, Jian Gao
Summary: The study found that Sodium Houttuyfonate could effectively alleviate bleomycin-induced pulmonary fibrosis in mice by reducing inflammation, fibrogenesis, and lung/body weight ratio. The protective effects of SH were comparable to prednisone acetate tablets in treating immunological diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lejla Medzikovic, Hylja Heese, Pieter B. van Loenen, Cindy P. A. A. van Roomen, Ingeborg B. Hooijkaas, Vincent M. Christoffels, Esther E. Creemers, Carlie J. M. de Vries, Vivian de Waard
Summary: Nur77 regulates cardiac fibrosis by promoting CF-to-MyoFB transition intrinsically and inhibiting cardiomyocyte-driven paracrine TGF-beta-mediated MyoFB differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yuko Ishida, Yumi Kuninaka, Naofumi Mukaida, Toshikazu Kondo
Summary: Fibrosis and structural remodeling of lung tissue can seriously impact lung function and have fatal consequences. The causes of pulmonary fibrosis (PF) vary, including allergens, chemicals, radiation, and environmental particles. The cause of idiopathic PF (IPF), one of the most common forms, is still unknown. The murine bleomycin (BLM) model has been extensively studied to understand the mechanisms of PF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Lingling Deng, Boshu Ouyang, Hanlin Shi, Fangyong Yang, Shihuan Li, Cong Xie, Wenjing Du, Lingli Hu, Ying Wei, Jingcheng Dong
Summary: Numerous studies have shown that Icariside II (ISE II) plays a significant role in preventing and treating various chronic diseases such as diabetes and fibrosis in different organs. This study investigated the therapeutic effect of ISE II in models of pulmonary fibrosis and found that it inhibits pro-fibrotic macrophage polarization by modulating the WNT/β-catenin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Karina Gonzalez-Garcia, Armando Lopez-Martinez, Juan Manuel Velazquez-Enriquez, Cecilia Zertuche-Martinez, Gabriela Carrasco-Torres, Luis Manuel Sanchez-Navarro, Saul Villa-Trevino, Rafael Baltierrez-Hoyos, Veronica Rocio Vasquez-Garzon
Summary: This study suggests that 3'5-dimaleamylbenzoic acid (3'5-DMBA) could be a promising candidate for the treatment of idiopathic pulmonary fibrosis (IPF) by reducing fibrosis, inflammation, and oxidative damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han, Chunhui Ni
Summary: The study found that metformin significantly reduced lung inflammation and fibrosis in silica-induced lung fibrosis model. Metformin reversed silica-induced cell toxicity, oxidative stress, and epithelial-mesenchymal transition process in epithelial cells and macrophages, as well as alleviated TGF-beta 1-stimulated fibroblast activation in lung fibroblasts via an AMPK-dependent pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Xionghua Sun, Mei Zhu, Wei Xia, Xihan Xu, Jian Zhang, Xiaogang Jiang
Summary: This study found that total sesquiterpenoids from Eupatorium lindleyanum DC. (TS-EL) exhibit antifibrotic activity. TS-EL reduces the increase in α-smooth muscle actin (α-SMA), type I collagen, and fibronectin content, as well as the formation of cell filaments and collagen gel contraction in human lung fibroblasts stimulated by transforming growth factor-β1. TS-EL does not affect the phosphorylation of Smad2/3 and Erk1/2, but it decreases the expression of serum response factor (SRF), a critical transcription factor of α-SMA, thus alleviating the transition of lung myofibroblasts. In addition, TS-EL attenuates bleomycin-induced lung pathology and collagen deposition in mice, and it also reduces the levels of SRF protein expression.
Article
Developmental Biology
Emily M. A. Lewis, Savita Sankar, Caili Tong, Ethan S. Patterson, Laura E. Waller, Paul Gontarz, Bo Zhang, David M. Ornitz, Kristen L. Kroll
DEVELOPMENTAL BIOLOGY
(2020)
Article
Anatomy & Morphology
Lu M. Yang, Lisa Stout, Michael Rauchman, David M. Ornitz
DEVELOPMENTAL DYNAMICS
(2020)
Article
Anatomy & Morphology
Yutao Su, Lu M. Yang, David M. Ornitz
Summary: The study indicates that both MAPK and PI3K pathways are crucial downstream mediators of FGF20-FGFR1 signaling in cochlear hair cell and supporting cell differentiation.
DEVELOPMENTAL DYNAMICS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Robert Guzy, Elizabeth F. Redente
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Letter
Biochemistry & Molecular Biology
David Wu, Tzu-Han Lee, Ru-Ting Huang, Robert D. Guzy, Nathan Schoettler, Ayodeji Adegunsoye, Jeffrey Mueller, Aliya Husain, Anne I. Sperling, Gokhan M. Mutlu, Yun Fang
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Pathology
Phillip McMullen, Peter Pytel, Alexis Snyder, Heather Smith, Jasmine Vickery, James Brainer, Robert Guzy, David Wu, Nathan Schoettler, Ayodeji Adegunsoye, Anne Sperling, John Hart, Lindsay Alpert, Anthony Chang, Sandeep Gurbuxani, Thomas Krausz, Aliya N. Husain, Jeffrey Mueller
Summary: Autopsies of COVID-19 patients have revealed clinical and histologic features similar to fatal cases of seasonal influenza, with overlapping pathological findings between the two diseases. There were no significant differences in inflammatory infiltrates at sites of acute lung injury between COVID-19 and influenza cases. The study emphasizes the relatively nonspecific clinical features and shared pathological changes between severe COVID-19 and influenza cases, while also cautioning about ancillary methods of viral detection.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2021)
Article
Anatomy & Morphology
Connor C. Leek, Jaclyn M. Soulas, Iman Bhattacharya, Elahe Ganji, Ryan C. Locke, Megan C. Smith, Jaysheel D. Bhavsar, Shawn W. Polson, David M. Ornitz, Megan L. Killian
Summary: This study investigated the role of Fgf9 in regulating the size of the deltoid tuberosity, revealing that Fgf9 deficiency affected cartilage growth and mineralization, as well as transcriptional profiles of skeletal muscle. The findings suggest that Fgf9 may play a crucial role in muscle-bone cross-talk during both embryonic and postnatal development.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Cell Biology
Jessica Weant, David D. Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M. Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A. Bradshaw
Summary: The two human FGF1 derivatives showed promising results in stimulating rabbit corneal endothelial cell proliferation, indicating their potential for regenerating corneal endothelial deficits in humans.
Editorial Material
Biochemistry & Molecular Biology
Robert D. Guzy, Seth Bollenbecker, Stefanie Krick
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elahe Ganji, Connor Leek, William Duncan, Debabrata Patra, David M. Ornitz, Megan L. Killian
Summary: This study investigates the role of Fgf9 in the development and function of the postnatal enthesis. By conditional knockout of Fgf9 in mouse tendons and entheses, the researchers found that Fgf9 is important for the structural and functional development of the enthesis. Mice with Fgf9 knockout showed thinner tendons, reduced bone mineralization, increased cellularity, and decreased mechanical properties in the entheses.
Article
Cardiac & Cardiovascular Systems
Dzmitry Matsiukevich, Attila Kovacs, Tiandao Li, Kristen Kokkonen-Simon, Scot J. Matkovich, Sunday S. Oladipupo, David M. Ornitz
Summary: Heart failure (HF) is a common and serious condition, particularly in older adults and patients with multiple metabolic comorbidities. Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by organ dysfunction and symptoms of heart failure, despite a normal or near-normal left ventricular ejection fraction. In this study, researchers successfully created a rodent model with a robust HFpEF phenotype, exhibiting characteristics and manifestations similar to the human disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Anatomy & Morphology
Kendra K. Wernle, Michael A. Sonnenfelt, Connor C. Leek, Elahe Ganji, Anna Lia Sullivan, Claudia Offutt, Jordan Shuff, David M. Ornitz, Megan L. Killian
Summary: The study reveals that FGFR signaling plays a critical role in regulating the growth and maintenance of tendon/ligament attachments and the size and shape of bony eminences.
DEVELOPMENTAL DYNAMICS
(2023)
Review
Medicine, Research & Experimental
David M. Ornitz, Nobuyuki Itoh
Summary: This review provides an overview of the fibroblast growth factor (FGF) family and focuses on new developments in the field since 2015. Highlights of the past 6 years include advancements in experimental modulation of FGF signaling, clinical use of small molecule FGFR inhibitors, expanded understanding of endocrine FGF signaling, and the roles of FGF signaling in stem cells, tissue homeostasis, regeneration, and neuropsychiatric diseases.
WIRES MECHANISMS OF DISEASE
(2022)
Article
Medicine, Research & Experimental
Kel Vin Woo, Isabel Y. Shen, Carla J. Weinheimer, Attila Kovacs, Jessica Nigro, Chieh-Yu Lin, Murali Chakinala, Derek E. Byers, David M. Ornitz
Summary: Research suggests that activation of endothelial FGFR signaling could be therapeutic for hypoxia-induced pulmonary hypertension by inhibiting the TGF-beta pathway-mediated EndMT process.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Stephen Stone, Daniel J. Wegner, Jennifer A. Wambach, F. Sessions Cole, Fumihiko Urano, David M. Ornitz
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)