Article
Biochemistry & Molecular Biology
Meng Yang, Asigul Ismayil, Zhihao Jiang, Yan Wang, Xiyin Zheng, Liming Yan, Yiguo Hong, Dawei Li, Yule Liu
Summary: The study reveals that the replicase gamma a of Barley stripe mosaic virus can inhibit vacuolar acidification and suppress autophagic degradation to promote viral infection in plants. The disruption of vacuolar acidification seems to be a common viral counter-defense strategy employed by multiple viruses, highlighting the importance of functional vacuolar acidification in plant antiviral defense.
Editorial Material
Cell Biology
Meng Yang, Yan Wang, Dawei Li, Yule Liu
Summary: This article discusses how plant viruses promote infection by interfering with vacuolar acidification and the degradation of autophagic bodies.
Article
Cell Biology
Michelle E. Maxson, Yazan M. Abbas, Jing Ze Wu, Jonathan D. Plumb, Sergio Grinstein, John L. Rubinstein
Summary: This study shows that proton-pumping vacuolar H+ ATPases (V-ATPases) are responsible for the acidic environment in secretory and endocytic organelles. The researchers developed a new probe derived from SidK protein to visualize and quantify V-ATPases with high specificity. They found that the density of V-ATPases increases during phagosome maturation and their distribution varies in lysosomes depending on their subcellular localization.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Min Fu, Yuanpeng Gao, Wenxing Guo, Qi Meng, Qi Jin, Rui Yang, Ying Yang, Yaqi Zhang, Wanqi Zhang
Summary: This research investigates the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. The study found that milk iodine concentration is positively correlated with iodine intake, and the regulation of glycosylation and degradation of NIS by DPAGT1 and VCP in the mammary gland plays a role in regulating milk iodine level. However, the mammary gland has limited ability to compensate for iodine deficiency and excess.
Article
Agriculture, Dairy & Animal Science
Jinbo Wu, Shiming He, Zhonghua Yu, Daoliang Lan, Xianrong Xiong, Zhu Li
Summary: In this study, RNA-seq was used to analyze the mammary gland transcriptomes of high-yielding and low-yielding yaks during lactation. The results showed that 144 differential genes were identified, which were involved in various biological processes such as carbohydrate metabolism. This study provides new insights into the molecular mechanism of yak mammary gland tissue and potential strategies for improving milk production in yaks.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Rizaldy C. Zapata, Maria Carretero, Felipe Castellani Gomes Reis, Besma S. Chaudry, Jachelle Ofrecio, Dinghong Zhang, Roman Sasik, Theodore Ciaraldi, Michael Petrascheck, Olivia Osborn
Summary: Energy metabolism remains dysregulated after weight loss in individuals with obesity, known as "metabolic memory". Using mouse and C. elegans models, this study identified ATP6v0a1 as a key gene involved in regulating food intake and weight gain, persisting even after weight loss.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Rong Xuan, Jianmin Wang, Qing Li, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Peipei He, Zhibin Ji, Tianle Chao
Summary: This study conducted transcriptome sequencing of goat-mammary-gland tissue at different developmental stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified, with 2528 circRNAs expressed in all three stages. Gene ontology analysis showed functional diversity of circRNAs' source genes. Furthermore, differentially expressed circRNAs and circRNA-miRNA-mRNA ceRNA regulatory networks were identified, providing insights into the regulatory role of circRNAs in mammary cell involution and remodeling.
Article
Agriculture, Dairy & Animal Science
Wei Xia, Yili Liu, Juan J. Loor, Massimo Bionaz, Mingfeng Jiang
Summary: This study evaluated the transcriptome of mammary tissue in four yaks throughout the lactation cycle. The analysis identified over 6000 differentially expressed genes, with a large number of genes showing differential expression at the onset and end of lactation. The functions affected by transcriptomic adaptation to lactation in yak mammary tissue were similar to those observed in dairy cows, including induction of lipid metabolism, amino acid metabolism, and glycan biosynthesis, as well as suppression of the cell cycle and immune response.
Review
Pharmacology & Pharmacy
Ge-Hong Sun-Wada, Yoh Wada
Summary: Vacuolar-type H+-ATPase (V-ATPase) is an electrogenic proton pump that acidifies intracellular organelles and also participates in the acidification of extracellular compartments. It plays important roles in cell biological processes and physiological functions by generating an acidic pH. Acidic endocytic organelles and their trafficking are important for cell polarity maintenance, and V-ATPase is involved in the establishment and maintenance of apico-basal polarity.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Cell Biology
Ivan Luzardo-Ocampo, Jose L. Dena-Beltran, Xarubet Ruiz-Herrera, Ana Luisa Ocampo-Ruiz, Gonzalo Martinez de la Escalera, Carmen Clapp, Yazmin Macotela
Summary: Obesity is a modern pandemic that negatively impacts women's reproductive health. Women with obesity experience changes in their mammary glands which affect their ability to exclusively breastfeed. The hormone prolactin, which is responsible for lactation, has reduced activity in the mammary glands of obese lactating rodents, contributing to impaired lactation. Treatment with prolactin has shown to improve milk production in women with inadequate lactation. This review focuses on the effects of diet-induced obesity on lactating mammary glands and how obesity impairs the lactogenic action of prolactin. While the impact of obesity on lactation has been studied in both humans and rodents, most of the research has been conducted on rodents.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Agriculture, Dairy & Animal Science
J. Y. Dourmad, J. J. Matte
Summary: During lactation, the mammary gland in sows adapts its metabolism quickly in response to short-term changes in nutrient availability, demonstrating a rapid ability to adjust nutrient uptake and modify metabolism according to the nutrients in the bloodstream.
Article
Multidisciplinary Sciences
Ge-Hong Sun-Wada, Hiroyuki Tabata, Yoh Wada
Summary: V-ATPase plays a crucial role in early embryonic development, and its lack can severely affect the structure of epithelial tissues in embryos.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
Divakar S. Karanth, Macey L. Martin, Lexie S. Holliday
Summary: Osteoclasts differentiate from hematopoietic cells and resorb bone in response to various signals, including those received directly from noncellular elements of the bone. Understanding the interactions between osteoclasts and the bone is crucial for developing bone biomimetics and new strategies for treating bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Sooyeon Lee, Shannon L. Kelleher
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Physiology
Nicholas H. McCormick, Sooyeon Lee, Stephen R. Hennigar, Shannon L. Kelleher
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Sooyeon Lee, Shannon L. Kelleher
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Physiology
Olivia C. Rivera, Stephen R. Hennigar, Shannon L. Kelleher
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Sooyeon Lee, Yandong Zhou, Donald L. Gill, Shannon L. Kelleher
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Shannon L. Kelleher, Annie Gagnon, Olivia C. Rivera, Steven D. Hicks, Molly C. Carney, Samina Alam
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Olivia C. Rivera, Donna T. Geddes, Shiran Barber-Zucker, Raz Zarivach, Annie Gagnon, David Soybel, Shannon L. Kelleher
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Wei Ding, Olivia C. Rivera, Shannon L. Kelleher, David Soybel
Article
Endocrinology & Metabolism
Rayhan A. Lal, Hannah P. Moeller, Ella A. Thomson, Timothy M. Horton, Sooyeon Lee, Raquel Freeman, Priya Prahalad, Ada S. Y. Poon, Justin P. Annes
Summary: In this study, a novel INS gene mutation (p.T97P) was identified, which disrupts proinsulin folding and processing, leading to the development of MIDY. This mutation induces endoplasmic reticulum stress and impairs insulin secretion.
Article
Endocrinology & Metabolism
Sooyeon Lee, Haixia Xu, Aidan Van Vleck, Alex M. Mawla, Albert Mao Li, Jiangbin Ye, Mark O. Huising, Justin P. Annes
Summary: Mitochondrial dysfunction plays a central role in type 2 diabetes, and the pathogenic mechanisms in pancreatic beta-cells are not fully understood. In this study, using samples from diabetic individuals and a mouse model, the authors demonstrate that succinate dehydrogenase (SDH) deficiency drives mitochondrial dysfunction in beta-cell failure and insulinopenic diabetes. SDH deficiency impairs glucose-induced respiratory oxidative phosphorylation and compromises glucose-stimulated ATP production, insulin secretion, and beta-cell growth. The loss of SDH causes excess succinate accumulation, which activates metabolic anabolism and lipid synthesis. This study suggests that SDH deficiency is a contributing mechanism to progressive beta-cell failure in diabetes and identifies mTOR complex 1 inhibition as a potential strategy for mitigation.
Article
Biochemistry & Molecular Biology
Timothy M. Horton, Paul A. Allegretti, Sooyeon Lee, Hannah P. Moeller, Mark Smith, Justin P. Annes
CELL CHEMICAL BIOLOGY
(2019)
Article
Endocrinology & Metabolism
Yassan Abdolazimi, Zhengshan Zhao, Sooyeon Lee, Haixia Xu, Paul Allegretti, Timothy M. Horton, Benjamin Yeh, Hannah P. Moeller, Robert J. Nichols, David McCutcheon, Aryaman Shalizi, Mark Smith, Neali A. Armstrong, Justin P. Annes
Article
Endocrinology & Metabolism
Guadalupe Navarro, Yassan Abdolazami, Zhengshan Zhao, Haixia Xu, Sooyeon Lee, Neali A. Armstrong, Justin P. Annes